Ratheesh K. Meleppat
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View article: Radiation shielding properties of xPbF2−20Na2O−10CaO−(70−x) B2O3 glass system
Radiation shielding properties of xPbF2−20Na2O−10CaO−(70−x) B2O3 glass system Open
The influence of PbF2 incorporation on the physical and radiation shielding properties of six glass samples, labeled BPbF0 to BPbF25, was investigated. These samples have a composition of xPbF2−20Na2O−10CaO−(70−x) B2O3 where (0≤x≤25 in 5 m…
View article: On-axis full-field swept-source optical coherence tomography for murine retinal imaging
On-axis full-field swept-source optical coherence tomography for murine retinal imaging Open
A full-field swept-source optical coherence tomography (FF-SS-OCT) for in vivo murine retinal imaging is demonstrated. The on-axis FF-SS-OCT system was built in a Mach–Zehnder interferometer configuration employing a tunable laser source w…
View article: High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope
High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope Open
High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmosocope (AO-pcMLO) is described. It allows for simultaneous confocal and phase contrast imaging with various direction…
View article: Contributed Session I: Human cone response models for optoretinography with FF-SS-OCT and adaptive optics
Contributed Session I: Human cone response models for optoretinography with FF-SS-OCT and adaptive optics Open
Recent work has shown that human rod and cone outer segments (ROS and COS, respectively) deform in response to visual stimuli. In phase-based optoretinography (ORG) the phases of backscattered light from the inner/outer segment junction (I…
View article: Programmable, high-speed, adaptive optics partially confocal multi-spot ophthalmoscope using a digital micromirror device
Programmable, high-speed, adaptive optics partially confocal multi-spot ophthalmoscope using a digital micromirror device Open
A high-speed, adaptive optics partially confocal multi-spot ophthalmoscope (AO-pcMSO) using a digital micromirror device (DMD) in the illumination channel and a fast 2D CMOS camera is described. The camera is synchronized with the DMD allo…
View article: In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography
In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography Open
In vivo characterization of retinal morphology and vasculature plexus of multiple species using SS-OCT and SS-OCTA imaging can increase the pool of species available as models of human retinal diseases.
View article: CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization
CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization Open
View article: Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system
Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system Open
Several specialized retinal optical coherence tomography (OCT) acquisition and processing methods have been recently developed to allow in vivo probing of light-evoked photoreceptors function, focusing on measurements in individual photore…
View article: In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium
In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium Open
View article: Optically-triggered oxidative stress in mouse RPE as a model of geographic atrophy in AMD
Optically-triggered oxidative stress in mouse RPE as a model of geographic atrophy in AMD Open
View article: Multicolor confocal fluorescence microscopy provides the enhanced visualization and fluorescent emission properties of intrinsic fluorophores in retinal pigment epithelium cells
Multicolor confocal fluorescence microscopy provides the enhanced visualization and fluorescent emission properties of intrinsic fluorophores in retinal pigment epithelium cells Open
View article: In Vivo Multimodal Retinal Imaging Correlates With Granular-specific Changes in the Organelles of Retinal Pigment Epithelium of a Murine Model of Stargardt Disease
In Vivo Multimodal Retinal Imaging Correlates With Granular-specific Changes in the Organelles of Retinal Pigment Epithelium of a Murine Model of Stargardt Disease Open
Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of granular pigmented organelles found in the retinal pigment epithelium (RPE) cells. Changes in the density of melanosomes and lipofuscin granules in RPE cells ar…
View article: In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging
In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging Open
A detailed assessment of the RPE autofluorescent granules and their changes ex vivo was possible with MCFM. For all excitation wavelengths, autofluorescence from the RPE cells was predominantly contributed by lipofuscin granules, while mel…
View article: Interpretation of OCT based Optoretinograms (ORG) measured in vivo in mice with mild diffuse central retinal edema: update on light evoked functional retinal imaging
Interpretation of OCT based Optoretinograms (ORG) measured in vivo in mice with mild diffuse central retinal edema: update on light evoked functional retinal imaging Open
View article: MicroRNAs as unique biomarkers and potential therapeutic targets for diabetic retinopathy
MicroRNAs as unique biomarkers and potential therapeutic targets for diabetic retinopathy Open
View article: In vivo studies of changes in Photoreceptor-RPE-Choroid Neurovascular Unit (PRC-NVU) morphology and function in the mouse models of Doyne Honeycomb Retinal Dystrophy and RPE mitochondrial dysfunction
In vivo studies of changes in Photoreceptor-RPE-Choroid Neurovascular Unit (PRC-NVU) morphology and function in the mouse models of Doyne Honeycomb Retinal Dystrophy and RPE mitochondrial dysfunction Open
View article: Angular compounding in Optical Coherence Tomography for speckle reduction and enhanced visualization of directional scattering in retinal OCT and OCT angiography images
Angular compounding in Optical Coherence Tomography for speckle reduction and enhanced visualization of directional scattering in retinal OCT and OCT angiography images Open
View article: Factors Impacting Efficacy of AAV-Mediated CRISPR-Based Genome Editing for Treatment of Choroidal Neovascularization
Factors Impacting Efficacy of AAV-Mediated CRISPR-Based Genome Editing for Treatment of Choroidal Neovascularization Open
View article: Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging
Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging Open
It has been recently demonstrated that structures corresponding to the cell bodies of highly transparent cells in the retinal ganglion cell layer could be visualized noninvasively in the living human eye by optical coherence tomography (OC…
View article: Increased scattering by the RPE of Abca4-/- mice relative to WT controls measured with OCT in vivo correlates with increased fundus autofluorescence measured with SLO
Increased scattering by the RPE of Abca4-/- mice relative to WT controls measured with OCT in vivo correlates with increased fundus autofluorescence measured with SLO Open
View article: Light induced water movement in the outer retina investigated by Optical Coherence Tomography
Light induced water movement in the outer retina investigated by Optical Coherence Tomography Open
View article: Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium
Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium Open
Optical coherence tomography (OCT) is a powerful tool in ophthalmology that provides in vivo morphology of the retinal layers and their light scattering properties. The directional (angular) reflectivity of the retinal layers was investiga…
View article: Built-in Fluorescence Anisotropy: an in vivo Imaging Probe for bis-Retinoid Products in Retina
Built-in Fluorescence Anisotropy: an in vivo Imaging Probe for bis-Retinoid Products in Retina Open
Non-degradable fluorophores that accumulate as Lipofuscin in retinal pigment epithelium (RPE) cells has been a major source of intrinsic biomarker for quantifying the progression of several diseases, including age-related macular degenerat…
View article: Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography
Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography Open
Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffe…
View article: Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography
Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography Open
Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noi…
View article: Longitudinal monitoring of Photoreceptor-RPE-Choroid Neurovascular Unit (PRC-NVU) morphology and function in the mouse model of Doyne Honeycomb Retinal Dystrophy
Longitudinal monitoring of Photoreceptor-RPE-Choroid Neurovascular Unit (PRC-NVU) morphology and function in the mouse model of Doyne Honeycomb Retinal Dystrophy Open
View article: Investigation of angular reflectivity of mouse retina layers using directional optical coherence tomography system
Investigation of angular reflectivity of mouse retina layers using directional optical coherence tomography system Open
View article: Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations
Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations Open
For in vivo mouse retinal imaging, especially with Adaptive Optics instruments, application of a contact lens is desirable, as it allows maintenance of cornea hydration and helps to prevent cataract formation during lengthy imaging session…
View article: Investigation into swept source based optical coherence tomography for bio-imaging
Investigation into swept source based optical coherence tomography for bio-imaging Open
Optical imaging at both the macroscopic and microscopic levels is used intensively these days by clinicians for diagnosis and treatment. New advances in optics, data acquisition, and signal processing enabled the development of novel optic…
View article: Quantitative optical coherence microscopy for the <i>in situ</i> investigation of the biofilm
Quantitative optical coherence microscopy for the <i>in situ</i> investigation of the biofilm Open
This paper explores the potential of optical coherence microscopy (OCM) for the