Muzafar Ahmad Rather
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View article: Retro-inversion imparts antimycobacterial specificity to host defense peptides
Retro-inversion imparts antimycobacterial specificity to host defense peptides Open
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant ret…
View article: In vitro investigation of Datura innoxia phytocompounds against Mycobacterium tuberculosis H37Ra strain in association with in silico studies
In vitro investigation of Datura innoxia phytocompounds against Mycobacterium tuberculosis H37Ra strain in association with in silico studies Open
Tuberculosis (TB) is a recurrent and progressive bacterial disease caused by Mycobacterium tuberculosis ( Mtb ), posing a significant challenge globally due to its drug resistance. This study focuses on identifying natural phytocompounds f…
View article: Essential Role of MHC II in the Antitubercular Efficacy of Pyrazinamide
Essential Role of MHC II in the Antitubercular Efficacy of Pyrazinamide Open
Antibacterial drug mechanisms have traditionally been examined through a drug-pathogen lens, often overlooking the host’s role in shaping drug activity. However, growing evidence suggests that the host environment is crucial for antibacter…
View article: Identification of Datura innoxia as a potential source of antimycobacterial components
Identification of Datura innoxia as a potential source of antimycobacterial components Open
Datura innoxia is a medicinal plant from the Solanaceae family, having medicinal properties and some toxic effects. It is widely distributed across Asia, Africa, Europe, the Americas, and other tropical and subtropical regions, where it is…
View article: Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis
Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis Open
Pyrazinamide (PZA) is a critical component of tuberculosis first-line therapy due to its ability to kill both growing and non-replicating drug-tolerant populations of Mycobacterium tuberculosis within the host. Recent evidence indicates th…
View article: Author response: Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis
Author response: Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis Open
View article: Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis
Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis Open
Pyrazinamide (PZA) is a critical component of tuberculosis first-line therapy due to its ability to kill both growing and non-replicating drug-tolerant populations of Mycobacterium tuberculosis within the host. Recent evidence indicates th…
View article: Essential Role of CD4 T Cells in the Antitubercular Efficacy of Pyrazinamide
Essential Role of CD4 T Cells in the Antitubercular Efficacy of Pyrazinamide Open
View article: Oxidative stress drives potent bactericidal activity of pyrazinamide against <i>Mycobacterium tuberculosis</i>
Oxidative stress drives potent bactericidal activity of pyrazinamide against <i>Mycobacterium tuberculosis</i> Open
Pyrazinamide (PZA) is a critical component of tuberculosis first-line therapy due to its ability to kill both growing and non-replicating drug-tolerant populations of Mycobacterium tuberculosis within the host. Recent evidence indicates th…
View article: Healing the Wound
Healing the Wound Open
The Good Doctor Muses,Will You be bound?And I Remember,Surgeons ask and tapmy swollen shin and splinter the skin to leechout the infection. The leather straps snapin calloused hands while others reachinto cowhide and pigskin bags. Their fi…
View article: Review of: "Antimicrobial Sensitivity of Plant Extracts of Acacia arabica, Prosopis juliflora, Abutilon indicum, and Bryonia laciniosa on Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli"
Review of: "Antimicrobial Sensitivity of Plant Extracts of Acacia arabica, Prosopis juliflora, Abutilon indicum, and Bryonia laciniosa on Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli" Open
View article: Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya
Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya Open
View article: Isolation, bioevaluation and RP-HPLC method development for the chemical constituents of aerial parts of Scutellaria prostrata Jacq. ex Benth
Isolation, bioevaluation and RP-HPLC method development for the chemical constituents of aerial parts of Scutellaria prostrata Jacq. ex Benth Open
Scutellaria (Lamiaceae), commonly known as skullcaps, is one of the most popular and multi-purpose herb used in China traditionally for treatment of inflammation, hypertension, cardiovascular diseases, bacterial and viral infections. Chemi…
View article: Repurposing of <i>Mycobacterium indicus pranii</i> for the severe form of COVID‐19 patients in India: A cohort study
Repurposing of <i>Mycobacterium indicus pranii</i> for the severe form of COVID‐19 patients in India: A cohort study Open
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces the production of proinflammatory cytokines, which results in a cytokine storm, and immune‐modulators like Mycobacterium indicus pranii (MIP) might ameliorate coronavirus…
View article: DFT and TD-DFT Study of Only First Diaminomalenonitrile Based Molecular Receptor for Fluoride Anion: Correlation of Calculated and Experimental Results
DFT and TD-DFT Study of Only First Diaminomalenonitrile Based Molecular Receptor for Fluoride Anion: Correlation of Calculated and Experimental Results Open
In this work, the sensing mechanism of a novel anion receptor, 2-amino-((E)-(4-cyanobenzalidine) amino) maleonitrile reported by Sankar et al. (Analyst 138:4760-4763, 2013) was investigated theoretically with the help of density functional…
View article: An update on emerging therapeutics to combat COVID‐19
An update on emerging therapeutics to combat COVID‐19 Open
Background The COVID‐19 pandemic has demanded effective therapeutic protocol from researchers and clinicians across the world. Currently, a large amount of primary data have been generated from several preclinical studies. At least 300 cli…
View article: In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis
In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis Open
View article: Medicinal plants: Treasure for antiviral drug discovery
Medicinal plants: Treasure for antiviral drug discovery Open
The pandemic of viral diseases like novel coronavirus (2019‐nCoV) prompted the scientific world to examine antiviral bioactive compounds rather than nucleic acid analogous, protease inhibitors, or other toxic synthetic molecules. The emerg…
View article: Ameliorative effects of <i>Cuscuta reflexa</i> and <i>Peucedanum grande</i> on letrozole induced polycystic ovary syndrome in Wistar rats
Ameliorative effects of <i>Cuscuta reflexa</i> and <i>Peucedanum grande</i> on letrozole induced polycystic ovary syndrome in Wistar rats Open
The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.
View article: In vitro bactericidal activity of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, drug-resistant and drug-tolerant isolates of Mycobacterium tuberculosis
In vitro bactericidal activity of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, drug-resistant and drug-tolerant isolates of Mycobacterium tuberculosis Open
View article: In vitro antimycobacterial activity of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione: A new chemical entity against Mycobacterium tuberculosis
In vitro antimycobacterial activity of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione: A new chemical entity against Mycobacterium tuberculosis Open
Background: In our on-going efforts towards tuberculosis (TB) drug discovery programme, a high-throughput whole cell-based phenotypic screening of thousands of compounds against Mycobacterium tuberculosis H37Rv lead to the identification o…
View article: In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) against drug susceptible and multidrug resistant strains of Mycobacterium tuberculosis
In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) against drug susceptible and multidrug resistant strains of Mycobacterium tuberculosis Open
Background: Tuberculosis is an ever evolving infectious disease that demands urgent need for new drugs. However, the discovery of new anti-TB drugs with high bactericidal activity against MDR-TB along with low toxicity, idle pharmacokineti…
View article: Synthesis and <i>in vitro</i> evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents
Synthesis and <i>in vitro</i> evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents Open
Tuberculosis is an ever-evolving infectious disease that urgently needs new drugs.
View article: Evaluation of antimicrobial and antioxidant activities of Swertia petiolata
Evaluation of antimicrobial and antioxidant activities of Swertia petiolata Open
View article: A comprehensive review on the phytochemical and pharmacological aspects of Podophyllum hexandrum: a high value medicinal plant
A comprehensive review on the phytochemical and pharmacological aspects of Podophyllum hexandrum: a high value medicinal plant Open
Podophyllum hexandrum Royle, a rhizomatous perennial herb from the Berberidaceae family, is a highly reputed medicinal plant known for its lignan, podophyllotoxin. Podophyllotoxin and its semisynthetic derivativatives are potent anticancer…