Ratika Sehgal
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View article: Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial
Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial Open
Time‐restricted eating (TRE) is a promising strategy against metabolic disorders, but its effects on lipid metabolism remain controversial. The present research assesses and compares the impact of early (eTRE) versus late (lTRE) TRE on the…
View article: Beyond Glucose—Rethinking Prediabetes for Precision Prevention
Beyond Glucose—Rethinking Prediabetes for Precision Prevention Open
Prediabetes affects more than one-third of U.S. adults, yet represents a biologically heterogeneous state that is only partly captured by traditional glycemic categories (impaired fasting glucose, impaired glucose tolerance, or borderline …
View article: Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction
Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction Open
Present study explores the role of liver lipidome in driving T2D-associated metabolic changes. Elevated liver triacylglycerols, reduced PUFAs, and 86 differentially abundant lipid species were identified in diabetes-prone mice. Of these al…
View article: Indole-3-propionic acid promotes hepatic stellate cells inactivation
Indole-3-propionic acid promotes hepatic stellate cells inactivation Open
View article: Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet—An exploratory study
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet—An exploratory study Open
Fatty acid desaturase (FADS1) variant-rs174550 strongly regulates polyunsaturated fatty acid (PUFA) biosynthesis. Additionally, the FADS1 is related to mitochondrial function. Thus, we investigated whether changes in mitochondrial function…
View article: Picalm, a novel regulator of GLUT4-trafficking in adipose tissue
Picalm, a novel regulator of GLUT4-trafficking in adipose tissue Open
View article: Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes
Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes Open
OB and T2D exhibit differential skeletal muscle transcriptome responses to bariatric surgery, presumably resulting from perturbed epigenetic flexibility.
View article: Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model Open
These data support the potential for using engineered microbial therapeutics in combination with dietary changes for managing MASLD.
View article: Sex Differences in the Indole-3-propionic Acid Responses to Laparoscopic Roux-en-Y gastric Bypass
Sex Differences in the Indole-3-propionic Acid Responses to Laparoscopic Roux-en-Y gastric Bypass Open
BACKGROUND Increased levels of indole-3-propionic acid (IPA), a gut-derived metabolite that lowers the risk of type 2 diabetes (T2D), may contribute to the metabolic benefits occurring after obesity surgery. We investigate whether the asso…
View article: Liver saturated fat content associates with hepatic DNA methylation in obese individuals
Liver saturated fat content associates with hepatic DNA methylation in obese individuals Open
Background Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been …
View article: Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease Open
An intricate relationship between gut microbiota, diet, and the human body has recently been extensively investigated. Gut microbiota and gut-derived metabolites, especially, tryptophan derivatives, modulate metabolic and immune functions …
View article: RF28 | PSUN301 Sex Differences in the Indolepropionic Acid Alterations in Response to Obesity Surgery
RF28 | PSUN301 Sex Differences in the Indolepropionic Acid Alterations in Response to Obesity Surgery Open
Introduction Obesity surgeries improve type 2 diabetes (T2D) in most cases, with effects frequently evident before substantial weight reduction. Therefore, this study hypothesizes that the increase in indolepropionic acid (IPA), a gut-deri…
View article: Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis
Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis Open
Background and Aims: Gut microbiota-derived metabolites play a vital role in maintenance of human health and progression of disorders, including obesity and type 2 diabetes (T2D). Indole-3-propionic acid (IPA), a gut-derived tryptophan met…
View article: Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids
Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids Open
Background & Aims Non‐alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non‐targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associ…
View article: <i>Aegle marmelos</i> impedes onset of insulin resistance syndrome in rats provided with drinking fructose from weaning to adulthood stages of development — a mechanistic study
<i>Aegle marmelos</i> impedes onset of insulin resistance syndrome in rats provided with drinking fructose from weaning to adulthood stages of development — a mechanistic study Open
In this study, we explored the effect of aqueous extract of leaves of Aegle marmelos (AM) on hepatic carbohydrate metabolism and insulin downstream signalling in rats given fructose (15%) in drinking water from weaning to adulthood. Wistar…
View article: Pharmacodynamic study of interaction of aqueous leaf extract of psidium guajava linn. (myrtaceae) with receptor systems using isolated tissue preparations
Pharmacodynamic study of interaction of aqueous leaf extract of psidium guajava linn. (myrtaceae) with receptor systems using isolated tissue preparations Open
The present study investigates the interaction of aqueous leaf extract of Psidium guajava with muscarinic, serotonergic and adrenergic receptor system using isolated rat ileum, gastric fundus and trachea, respectively. The concentration-de…
View article: Interaction of aqueous leaf extract of Aegle marmelos (L.) Corr. with cholinergic, serotonergic and adrenergic receptors: An ex vivo study
Interaction of aqueous leaf extract of Aegle marmelos (L.) Corr. with cholinergic, serotonergic and adrenergic receptors: An ex vivo study Open
It may be concluded that AM possesses agonistic activity on cholinergic, serotonergic and adrenergic receptors.