2023-07-27
Sex Differences in the Indole-3-propionic Acid Responses to Laparoscopic Roux-en-Y gastric Bypass
2023-07-27 • Jussi Pihlajamäki, Thais Silva, Ratika Sehgal, Poli Mara Spritzer, Anna Kårlund, Marjo Tuomainen, Ville Männistö, Leila Karhunen, Kati Hanhineva, M...
Abstract BACKGROUND Increased levels of indole-3-propionic acid (IPA), a gut-derived metabolite that lowers the risk of type 2 diabetes (T2D), may contribute to the metabolic benefits occurring after obesity surgery. We investigate whether the associations of serum IPA with insulin and glucose metabolism differ between men and women in response to laparoscopic Roux-en-Y gastric bypass (LRYGB) and compare the effects of LRYGB to the effect of a 7-week Very-Low Caloric Diet (VLCD) induced weight loss. METHODS Fastin…