Raul C. Maranhão
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View article: Brazilian Guideline on Dyslipidemias and Prevention of Atherosclerosis – 2025
Brazilian Guideline on Dyslipidemias and Prevention of Atherosclerosis – 2025 Open
View article: Effect of intravenous methotrexate carried by lipid nanoemulsion in patients with anterior ST-elevation myocardial infarction
Effect of intravenous methotrexate carried by lipid nanoemulsion in patients with anterior ST-elevation myocardial infarction Open
View article: The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL
The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL Open
High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but…
View article: Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats
Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats Open
Background This study aimed to investigate the effects of LDE-MTX on acute cerebral infarction. The study focuses on how LDE-MTX can influence the outcomes of ischemic stroke in a rat model, specifically examining its neuroprotective prope…
View article: Effects of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemia-reperfusion injury after unilateral lung transplantation in rats
Effects of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemia-reperfusion injury after unilateral lung transplantation in rats Open
View article: Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression
Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression Open
The variability in response to conventional prostate cancer (PC) therapies, coupled with the emergent issue of drug resistance, underscores the critical need for innovative treatment strategies. Aerobic physical exercise reduced incidence …
View article: Safety and possible anti-inflammatory effect of paclitaxel associated with LDL-like nanoparticles (LDE) in patients with chronic coronary artery disease: a double-blind, placebo-controlled pilot study
Safety and possible anti-inflammatory effect of paclitaxel associated with LDL-like nanoparticles (LDE) in patients with chronic coronary artery disease: a double-blind, placebo-controlled pilot study Open
Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. In addition, association wi…
View article: Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation
Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation Open
Introduction: During pregnancy, maternal lipid metabolism undergoes several transformations originated by hormonal changes. There are two distinct phases: initial and late, finally driven to hypertriglyceridemia. Maternal hyperlipidemia, e…
View article: Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults
Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults Open
The effects of regular physical activity on two important anti-atherosclerosis functions of high-density lipoprotein (HDL), namely its capacity to receive both forms of cholesterol and its anti-oxidant function, were investigated in this s…
View article: Use of Paclitaxel Associated to Lipid Core Nanoparticles (LDE) in the Second or Third Line Treatment of Advanced Pancreatic Adenocarcinoma
Use of Paclitaxel Associated to Lipid Core Nanoparticles (LDE) in the Second or Third Line Treatment of Advanced Pancreatic Adenocarcinoma Open
Background: Previously, we showed that paclitaxel carried in non-protein Lipid Core Nanoparticles (LDE) resembling the lipid structure of LDL has remarkably reduced toxicity in patients with advanced solid cancers, as used in 3rd line chem…
View article: Methotrexate associated with nanoparticles decreases NLRC4 inflammasome expression in infarcted rat hearts
Methotrexate associated with nanoparticles decreases NLRC4 inflammasome expression in infarcted rat hearts Open
Abstract: Following myocardial infarction (MI), molecules released from necrotic myocytes sensitize nucleotide-binding receptors (NLRs), activate inflammasome complex, and initiate acute inflammatory process and interleukin (IL)-1β product…
View article: Aerobic physical exercise enhances nanoparticle efficacy in prostate cancer treatment
Aerobic physical exercise enhances nanoparticle efficacy in prostate cancer treatment Open
The effectiveness of drugs currently employed for prostate cancer (PC) can vary, as they may not always yield satisfactory results. Moreover, resistance to these drugs can develop over time, rendering long-term therapy ineffective, dependi…
View article: Effects of CPAP Therapy on the HDL Metabolism of Patients with Metabolic Syndrome and Obstructive Sleep Apnea: A Substudy of TREATOSA-MS Randomized Trial
Effects of CPAP Therapy on the HDL Metabolism of Patients with Metabolic Syndrome and Obstructive Sleep Apnea: A Substudy of TREATOSA-MS Randomized Trial Open
Keywords cholesterol - HDL - continuous positive airway pressure - lipid metabolism - metabolic syndrome - sleep apnea - obstructive
View article: The Interplay of Sirtuin-1, LDL-Cholesterol, and HDL Function: A Randomized Controlled Trial Comparing the Effects of Energy Restriction and Atorvastatin on Women with Premature Coronary Artery Disease
The Interplay of Sirtuin-1, LDL-Cholesterol, and HDL Function: A Randomized Controlled Trial Comparing the Effects of Energy Restriction and Atorvastatin on Women with Premature Coronary Artery Disease Open
Introduction: HDL function has gained prominence in the literature as there is a greater predictive capacity for risk in early coronary artery disease when compared to the traditional parameters. However, it is unclear how dietary energy r…
View article: Effect of exercise training on HDL subclasses and cholesterol transfers to HDL in elderly individuals
Effect of exercise training on HDL subclasses and cholesterol transfers to HDL in elderly individuals Open
Introduction Lifestyle habits play a crucial role on coronary artery disease (CAD) prevention. Exercise training promotes increase of HDL-C and decrease of plasma triglycerides is an important tool against atherogenesis. HDL-C determinatio…
View article: Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial
Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial Open
View article: Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome
Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome Open
In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS. Previously, we showed that the formulation of…
View article: Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy
Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy Open
View article: Use of paclitaxel carried in solid lipid nanoparticles to prevent peritoneal fibrosis in rats
Use of paclitaxel carried in solid lipid nanoparticles to prevent peritoneal fibrosis in rats Open
Background Progressive fibrous thickening of peritoneal membrane (PM) is a major complication of long-term peritoneal dialysis. TGF-β/SMAD pathway activation, inflammation and neoangiogenesis have an important role in PM changes induced by…
View article: Use of paclitaxel carried in lipid core nanoparticles in patients with late-stage solid cancers with bone metastases: Lack of toxicity and therapeutic benefits
Use of paclitaxel carried in lipid core nanoparticles in patients with late-stage solid cancers with bone metastases: Lack of toxicity and therapeutic benefits Open
View article: Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer
Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer Open
View article: l-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals
l-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals Open
View article: Effect of Menopause and Hypertriglyceridemia on Lipid Transfer and Paraoxonase Activity in Diabetic Women
Effect of Menopause and Hypertriglyceridemia on Lipid Transfer and Paraoxonase Activity in Diabetic Women Open
Introduction. The high prevalence of type 2 diabetes mellitus (DM2) and cardiovascular atherosclerotic complications are increasing in women after menopause. Studies have shown that the in vitro transfer of lipids to HDL and the determinat…
View article: Use of paclitaxel carried in lipid nanoparticles to treat aortic allograft transplantation in rats
Use of paclitaxel carried in lipid nanoparticles to treat aortic allograft transplantation in rats Open
Objectives The aim of this study was to test whether lipid core nanoparticles loaded with paclitaxel (LDE-PTX) protect rat aortic allograft from immunological damage. Methods Fisher and Lewis rats were used differing in minor histocompatib…
View article: Chlorine and Chromium Elements, Proteins of Oxidative Stress and Dna Repair Pathways Are Related to Tumor Aggressiveness and Prognosis of Patients With Oral Cancer
Chlorine and Chromium Elements, Proteins of Oxidative Stress and Dna Repair Pathways Are Related to Tumor Aggressiveness and Prognosis of Patients With Oral Cancer Open
BackgroundSquamous cell carcinoma (OCSCC), the most frequent cancer of the oral cavity, is extremely aggressive, the response to treatment is poor and markers for prognosis of disease are scarce. The comparison of chemical and histopatholo…
View article: HYDROXYCHLOROQUINE IMPROVED LIPID TRANSFER TO HIGH-DENSITY LIPOPROTEIN IN SYSTEMIC LUPUS ERYTHEMATOSUS: A POSSIBLE MECHANISM FOR THE REVERSAL OF ATHEROSCLEROSIS IN THE DISEASE
HYDROXYCHLOROQUINE IMPROVED LIPID TRANSFER TO HIGH-DENSITY LIPOPROTEIN IN SYSTEMIC LUPUS ERYTHEMATOSUS: A POSSIBLE MECHANISM FOR THE REVERSAL OF ATHEROSCLEROSIS IN THE DISEASE Open
View article: Methotrexate associated with a lipid core nanoparticle prevented the dilation and dissection of the aortic arch in mice with Marfan syndrome
Methotrexate associated with a lipid core nanoparticle prevented the dilation and dissection of the aortic arch in mice with Marfan syndrome Open
Introduction Mutations in the fibrillin-1 gene result in dilation, dissection and rupture of the aorta, the main cause of mortality in patients with Marfan syndrome (MFS). Inflammation is associated with greater susceptibility to dissectio…
View article: Daunorubicin associated to lipid core nanoparticles reduces atherosclerotic lesions, inflammation and cardiotoxicity in atherosclerosis rabbit model
Daunorubicin associated to lipid core nanoparticles reduces atherosclerotic lesions, inflammation and cardiotoxicity in atherosclerosis rabbit model Open
Introduction Antiproliferative agents used in cancer chemotherapy have low toxicity and increased pharmacological action when carried into lipid core nanoparticles (LDE). LDE has similar structure to LDL and binds to LDL receptors through …
View article: Decellularized Splenic Matrix as a Scaffold for Spleen Bioengineering
Decellularized Splenic Matrix as a Scaffold for Spleen Bioengineering Open
The spleen is considered a non-essential organ. However, its importance is increasingly clear, given the serious disorders caused by its absence or dysfunction, e.g., greater susceptibility to infections, thromboembolism and cancer. Surgic…
View article: Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease
Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease Open