Raul Piseaux Aillon
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View article: Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging
Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging Open
Sarcopenia, which diminishes lifespan and healthspan in the elderly, is commonly exacerbated by viral pneumonia, including influenza and COVID-19. In a study of influenza A pneumonia in mice, young mice fully recovered from sarcopenia, whi…
View article: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions Open
The adherens junction component, alpha-T-catenin (αTcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, i…
View article: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions Open
The adherens junction component, alpha-T-catenin (αTcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, i…
View article: Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration
Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration Open
Epithelial polyploidization after injury is a conserved phenomenon recently shown to improve barrier restoration during wound healing. Whether lung injury can induce alveolar epithelial polyploidy is not known. We show that bleomycin injur…
View article: Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration
Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration Open
Epithelial polyploidization post-injury is a conserved phenomenon, recently shown to improve barrier restoration during wound healing. Whether lung injury can induce alveolar epithelial polyploidy is not known. We show that bleomycin injur…
View article: Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis Open
Significance Disordered epithelial proteostasis is strongly implicated in the pathobiology of pulmonary fibrosis. We found that a small molecule that specifically restores protein translation by EIF2B during activation of the integrated st…
View article: Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5
Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5 Open
Numerous studies have established that acute or chronic exposure to environmental pollutants like particulate matter (PM) leads to the development of accelerated aging related pathologies including pulmonary and cardiovascular diseases, an…
View article: The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging Open
Alveolar macrophages orchestrate the response to viral infections. Age-related changes in these cells may underlie the differential severity of pneumonia in older patients. We performed an integrated analysis of single-cell RNA-Seq data th…
View article: Impaired Phagocytic Function in CX3CR1<sup>+</sup> Tissue-Resident Skeletal Muscle Macrophages Prevents Muscle Recovery After Influenza A Virus-Induced Pneumonia in Aged Mice
Impaired Phagocytic Function in CX3CR1<sup>+</sup> Tissue-Resident Skeletal Muscle Macrophages Prevents Muscle Recovery After Influenza A Virus-Induced Pneumonia in Aged Mice Open
View article: Resetting proteostasis with ISRIB prevents pulmonary fibrosis
Resetting proteostasis with ISRIB prevents pulmonary fibrosis Open
Aging is among the most important risk factors for the development of pulmonary fibrosis. We found that a small molecule that specifically inhibits translational inhibition induced by activation of the integrated stress response (ISRIB) at…
View article: Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia
Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia Open
Rationale: The identification of informative elements of the host response to infection may improve the diagnosis and management of bacterial pneumonia. Objectives: To determine whether the absence of alveolar neutrophilia ca…