Ravi P. Sahu
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View article: High resolution air quality simulation in the Himalayan valleys, a case study in Bhutan
High resolution air quality simulation in the Himalayan valleys, a case study in Bhutan Open
Our study focuses on Bhutan, a highly mountainous country where government authorities are strengthening air pollution monitoring efforts. To support further analysis and the monitoring strategy, we present the first high-resolution air qu…
View article: Pioglitazone-Based Combination Approaches for Non-Small-Cell Lung Cancer
Pioglitazone-Based Combination Approaches for Non-Small-Cell Lung Cancer Open
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small-cell lung cancer (NSCLC) being the most prevalent subtype. NSCLC is marked by a complex genetic makeup, involving numerous driver mutations and epi…
View article: Are metformin-based combination approaches beneficial for non-small cell lung cancer: evidence from experimental and clinical studies
Are metformin-based combination approaches beneficial for non-small cell lung cancer: evidence from experimental and clinical studies Open
Despite having multiple treatment options, the overall outcomes, including the survival rates of non-small cell lung cancer (NSCLC) patients, remain relatively low, indicating the need to explore new approaches to achieve improved therapeu…
View article: Combining Immune Checkpoint Inhibitors and Anti-Angiogenesis Approaches: Treatment of Advanced Non-Small Cell Lung Cancer
Combining Immune Checkpoint Inhibitors and Anti-Angiogenesis Approaches: Treatment of Advanced Non-Small Cell Lung Cancer Open
Combining immune checkpoint inhibitors (ICIs) and anti-angiogenic pharmacologic agents is an encouraging therapeutic approach in the treatment of non-small cell lung cancer (NSCLC). Currently, the only FDA-approved therapy combining an imm…
View article: Sorafenib generates microvesicle particles in non-small cell lung cancer
Sorafenib generates microvesicle particles in non-small cell lung cancer Open
Despite the improved clinical outcomes resulting from the use of sorafenib, the development of resistance mechanisms continues to undermine its treatment efficacy. Recent studies have implicated the role of a phospholipid mediator, platele…
View article: Elevated HDAC4 Expression Is Associated with Reduced T-Cell Inflamed Tumor Microenvironment Gene Signatures and Immune Checkpoint Inhibitor Effectiveness in Melanoma
Elevated HDAC4 Expression Is Associated with Reduced T-Cell Inflamed Tumor Microenvironment Gene Signatures and Immune Checkpoint Inhibitor Effectiveness in Melanoma Open
Background/Objectives: Melanoma remains a difficult malignancy to treat because it employs tolerance mechanisms like negative immune checkpoint (IC) molecules to avoid antitumor immune responses. Thus, immune checkpoint inhibitors (ICIs) a…
View article: Metformin-Based Combination Approaches for Triple-Negative Breast Cancer
Metformin-Based Combination Approaches for Triple-Negative Breast Cancer Open
Numerous anti-diabetic medications, including metformin, have been explored for their anticancer effects because of the substantial correlation between diabetes and cancer incidence. Metformin has recently gained interest for its anticance…
View article: Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer Open
Cancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patients develop drug resistance, indicating the need for alternative approaches. Repurposed drugs, such as antiglycol…
View article: Scanning Electron Microscopic Studies on the Development of Epididymis and Vas Deferens in Non-descript Goat (Capra hircus) during Postnatal Period
Scanning Electron Microscopic Studies on the Development of Epididymis and Vas Deferens in Non-descript Goat (Capra hircus) during Postnatal Period Open
Background: The appearance and interaction of spermatozoa with the tubular epithelium is crucial for selection of non-descript goats for breeding purposes at the appropriate time. Further, various interventions can also be made for faster …
View article: Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents
Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents Open
Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatme…
View article: Development of Vermiwash Production Technique: Evaluation of its Physicochemical Parameters and Effect on Overall Plant Growth
Development of Vermiwash Production Technique: Evaluation of its Physicochemical Parameters and Effect on Overall Plant Growth Open
Soil health is a critical component of sustainable agriculture. Agricultural soil faces numerous challenges, such as erosion, nutrient depletion and contamination. Intensive farming practices such as mechanization, overuse of synthetic fer…
View article: Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer
Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer Open
The integration between the tumor-suppressive and oncogenic signaling pathways controls various cellular activities of cancer cells, including cell growth and apoptosis. While the activation of oncogenes fuels cancer progression and escape…
View article: Ultrastructural Characterization of Testis in Non-descript Goat (Capra hircus)
Ultrastructural Characterization of Testis in Non-descript Goat (Capra hircus) Open
Background: The proposed experiment was aimed at locating the spermatogonial stem cell niches inside the testis and to characterise the development of germ cells of testis in the non- descript goats at the different stages of pre and post …
View article: Efficacy of Sorafenib-Based Therapies for Non-Small Cell Lung Cancer
Efficacy of Sorafenib-Based Therapies for Non-Small Cell Lung Cancer Open
Lung cancer remains the leading cause of cancer-related deaths, with a poor prognosis. Of the two types, non-small cell lung cancer (NSCLC) is the major and most prevalent type and associated with low response rates to the current treatmen…
View article: Evidence that keratinocyte microvesicle particles carrying platelet-activating factor mediate the widespread multiorgan damage associated with intoxicated thermal burn injury
Evidence that keratinocyte microvesicle particles carrying platelet-activating factor mediate the widespread multiorgan damage associated with intoxicated thermal burn injury Open
Thermal burn injuries can result in significant morbidity and mortality. The combination of ethanol intoxication with thermal burn injury results in increased morbidity through an exaggerated inflammatory response involving many organs. Re…
View article: Evidence for the involvement of keratinocyte‐derived microvesicle particles in the photosensitivity associated with xeroderma pigmentosum type A deficiency
Evidence for the involvement of keratinocyte‐derived microvesicle particles in the photosensitivity associated with xeroderma pigmentosum type A deficiency Open
Photosensitivity can be due to numerous causes. The photosensitivity associated with deficiency of xeroderma pigmentosum type A (XPA) has been previously shown to be associated with excess levels of the lipid mediator platelet‐activating f…
View article: Anticancer Effects of Arsenic Compounds in Non-Small Cell Lung Cancer
Anticancer Effects of Arsenic Compounds in Non-Small Cell Lung Cancer Open
Non-small cell lung cancer (NSCLC) is the most common and prevalent subtype of lung cancer and continues to be one of the leading causes of cancer-related deaths worldwide. Despite various treatment options, a majority of NSCLC patients co…
View article: Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer
Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer Open
Lung cancer remains one of the major human malignancies affecting both men and women worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent type. Multiple mechanisms have been identified that favor tumor growth as well…
View article: Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer
Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer Open
The body of evidence investigating human epidermal growth factor receptor-2 (HER2) directed therapy in patients with breast cancer (BC) has been growing within the last decade. Recently, the use of tyrosine kinase inhibitors (TKIs) has bee…
View article: Radiation therapy produces microvesicle particle release in HaCaT keratinocytes
Radiation therapy produces microvesicle particle release in HaCaT keratinocytes Open
As cancer treatments experience technological advancements, radiation therapy (RT) provides a foundational and essential modality for the treatment of various malignancies. Ionizing radiation (IR), a form of RT, is tailored to individual p…
View article: Cover Image
Cover Image Open
The cover image is based on the Letter Exposure to diesel exhaust particulates and desert sand dust generates microvesicle particles and platelet-activating factor agonists by Anita Thyagarajan et al., https://doi.org/10.1111/srt.13312.
View article: Exposure to diesel exhaust particulates and desert sand dust generates microvesicle particles and platelet‐activating factor agonists
Exposure to diesel exhaust particulates and desert sand dust generates microvesicle particles and platelet‐activating factor agonists Open
The authors address the editor in their article, stating that the majority of the general population, particularly, servicemen and women deployed across the globe are exposed to various airborne hazards, including diesel exhaust particulat…
View article: Data from Spatiotemporal Assessments of Dermal Hyperemia Enable Accurate Prediction of Experimental Cutaneous Carcinogenesis as well as Chemopreventive Activity
Data from Spatiotemporal Assessments of Dermal Hyperemia Enable Accurate Prediction of Experimental Cutaneous Carcinogenesis as well as Chemopreventive Activity Open
Field cancerization refers to areas of grossly normal epithelium that exhibit increased risk for tumor occurrence. Unfortunately, elucidation of the locoregional changes that contribute to increased tumor risk is difficult due to the inabi…
View article: Table Supplementary S-I from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Table Supplementary S-I from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor Open
Table Supplementary S-I. Glycerophosphocholine species generated in response to etoposide treatment of B16F10 cells
View article: Supplementary Methods from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Supplementary Methods from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor Open
Supplementary Methods. Supplementary Mass spectrometric methodology
View article: Supplementary Methods, Figures 1-5, Table 1 from Spatiotemporal Assessments of Dermal Hyperemia Enable Accurate Prediction of Experimental Cutaneous Carcinogenesis as well as Chemopreventive Activity
Supplementary Methods, Figures 1-5, Table 1 from Spatiotemporal Assessments of Dermal Hyperemia Enable Accurate Prediction of Experimental Cutaneous Carcinogenesis as well as Chemopreventive Activity Open
PDF file - 690K, Foci of persistent dermal hyperemia reliably predict where murine cutaneous neoplasia will develop as well as the chemopreventive activity of Celexocib treatment