Ravi V. Shah
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View article: OMTRA: A Multi-Task Generative Model for Structure-Based Drug Design
OMTRA: A Multi-Task Generative Model for Structure-Based Drug Design Open
Structure-based drug design (SBDD) focuses on designing small-molecule ligands that bind to specific protein pockets. Computational methods are integral in modern SBDD workflows and often make use of virtual screening methods via docking o…
View article: A novel serum glucocorticoid regulated kinase 1 inhibitor improves cardiac structure and function in heart failure
A novel serum glucocorticoid regulated kinase 1 inhibitor improves cardiac structure and function in heart failure Open
Despite the advent of transformative guideline-directed therapy, heart failure (HF) remains a leading cause of hospitalization and mortality worldwide, underscoring an urgent need for novel therapies. Clinical benefits of contemporary inte…
View article: Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease
Proteomic signatures of pediatric cardiovascular and cardiometabolic traits demonstrate long-term modifiable drivers of adult disease Open
While the earliest pathological signs of cardiovascular disease (CVD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of high-risk children. With the rising prevalence of childhood obesity,…
View article: Determinants of hepatitis C virus treatment completion among Los Angeles County residents
Determinants of hepatitis C virus treatment completion among Los Angeles County residents Open
We verified low hepatitis C treatment completion at the population-level. Those 18-29 years old and diagnosed in primary care were least likely to complete treatment.
View article: A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia
A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia Open
Obesity contributes to the risk of cardiac arrhythmias, but the exact mechanism remains unclear. Here, we show visceral adipose tissue-derived extracellular vesicles (VAT EVs) from individuals with obesity prolong action potential duration…
View article: Integrating population-level and cell-based signatures for drug repositioning
Integrating population-level and cell-based signatures for drug repositioning Open
Motivation Drug repositioning presents a streamlined and cost-efficient way to expand the range of therapeutic possibilities. Drugs with human genetic evidence are more likely to advance successfully through clinical trials toward Food and…
View article: COVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program
COVID-19 Pandemic Exposure and Toddler Behavioral Health in the ECHO Program Open
Importance Studies suggest developmental concerns for infants born during the COVID-19 pandemic, but evidence on its impact on toddler behavioral and emotional well-being remains limited. Objective To assess whether birth timing relative t…
View article: A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort
A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort Open
Unintentional weight loss (UWL) is related to mortality and mobility limitation. Here, we aimed to develop a metabolite‐based score for UWL and evaluate its prediction performance and explanation value for UWL‐related health outcomes. Part…
View article: Dietary metabolic signatures and cardiometabolic risk
Dietary metabolic signatures and cardiometabolic risk Open
AIMS: Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD) focus on self-reported consumption of food or dietary pattern, with limited information on individual metabolic responses to dietary intake linked to CM…
View article: Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure
Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure Open
Pressure overload initiates a series of alterations in the human heart that predate macroscopic organ-level remodeling and downstream heart failure. We study aortic stenosis through integrated proteomic, tissue transcriptomic, and genetic …
View article: The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity
The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity Open
We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity (277 unique genes; false discovery rate < 10%). Since circulating EVs may have broad …
View article: Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort
Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort Open
Importance Inorganic arsenic is associated with adverse birth outcomes, but evidence is limited for public water concentrations (modifiable by federal regulatory action) in US populations. Objective To evaluate the association between pren…
View article: Gender and Sexting: Pilot Study on Sexting Motivation among Indian Young Adults
Gender and Sexting: Pilot Study on Sexting Motivation among Indian Young Adults Open
Background: This study investigates sexting motivations among young adults in Mumbai, India, emphasizing gender differences. Despite extensive global research, there is a significant gap in understanding sexting motivations within the Indi…
View article: Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes
Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes Open
OBJECTIVE To identify metabolic signatures of insulin action/secretion in Indigenous Americans (IAs) and their association with diabetes. RESEARCH DESIGN AND METHODS We defined circulating metabolomic signatures of insulin action/secretion…
View article: Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults
Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults Open
Background: Walking ability is important for the quality of life of older adults. A self-reported walking ability index (WAI) covering the difficulty and ease of walking captures a broader spectrum of walking ability in healthy older perso…
View article: Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention
Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention Open
Background Weight reduction through lifestyle, activity, and dietary interventions are the mainstay of initial therapy for metabolic dysfunction associated steatotic liver disease. Data on the relative effectiveness and metabolic pathways …
View article: Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years
Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Age 2 to 18 Years Open
Importance Higher blood pressure in early life may signal cardiovascular disease over the life course, but determinants of blood pressure in early life are poorly understood. Objective To examine the association of maternal cardiometabolic…
View article: Project HCV Connect: Using a County Surveillance Registry to Link Hepatitis C Virus-Infected Residents to Cure—Los Angeles County, April 2023 to March 2024
Project HCV Connect: Using a County Surveillance Registry to Link Hepatitis C Virus-Infected Residents to Cure—Los Angeles County, April 2023 to March 2024 Open
Los Angeles County has a high prevalence of chronic hepatitis C virus (HCV) infection, but resources and infrastructure to notify and increase treatment uptake among county residents are absent. Through an innovative academic-public partne…
View article: Molecular architecture of human atherosclerosis revealed through integrative human genetics
Molecular architecture of human atherosclerosis revealed through integrative human genetics Open
Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…
View article: Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics
Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics Open
Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current approaches to diagnosis rely on histology, which exhibits wide diagnostic variability and lacks access to molecular phen…
View article: Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome
Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome Open
Circulating miRNAs 223-3p and 378c were associated with the risk of HHF/CVD after adjustment for clinical factors and established cardiovascular biomarkers. Carrier-specific measurement of these miRNAs may emerge as novel minimally invasiv…
View article: Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM Open
View article: FINANCIAL STATUS OF THE RURAL ELDERLY WOMEN IN MAHARASHTRA DURING POST-COVID-19
FINANCIAL STATUS OF THE RURAL ELDERLY WOMEN IN MAHARASHTRA DURING POST-COVID-19 Open
Maharashtra-a state deeply affected by the COVID-19 pandemic-mirrors these challenges. With an estimated population of 125 million, 11.7% of whom are elderly (a figure projected to reach 15% by 2031), the state has been one of Indias harde…
View article: Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study
Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study Open
View article: Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort Open
Background Research suggests racial/ethnic disparities in prenatal exposure to endocrine disrupting environmental phenols (EPs) in limited populations. However, no studies have investigated racial/ethnic disparities in prenatal EP exposure…
View article: Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults
Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults Open
View article: Outcome-Driven Deep Clustering with Applications in Clinical Research
Outcome-Driven Deep Clustering with Applications in Clinical Research Open
View article: Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study
Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study Open
Study Objectives Research linking children’s sleep to cognitive outcomes is inconsistent and has largely focused on one aspect of sleep, such as duration, rather than measuring multiple dimensions of sleep health. We hypothesized that chil…
View article: Synchronous mid-descending colon cancer and jejunal intraluminal lipomas presenting as intussusception: A rare case report
Synchronous mid-descending colon cancer and jejunal intraluminal lipomas presenting as intussusception: A rare case report Open
View article: A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open