Ravi Sharaf
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View article: Misinterpreting the Results: Patient Misconceptions about Genetic Cancer Risk after Obstetrical Carrier Screening Shortened Title: Perceptions of Genetic Cancer Risk in Prenatal Carrier Screening
Misinterpreting the Results: Patient Misconceptions about Genetic Cancer Risk after Obstetrical Carrier Screening Shortened Title: Perceptions of Genetic Cancer Risk in Prenatal Carrier Screening Open
Obstetric carrier screening (OCS) is recommended for all individuals during pregnancy by leading professional societies. However, patient understanding of the scope and limitations of OCS remains poorly characterized, especially with regar…
View article: Mechanical thrombectomy for acute ischemic stroke in a low- and middle-income country: primary outcomes from the GRASSROOT Trial
Mechanical thrombectomy for acute ischemic stroke in a low- and middle-income country: primary outcomes from the GRASSROOT Trial Open
Background and aims Access to mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion (LVO) is severely restricted in resource-constrained environments, largely owing to the prohibitive cost of existing approv…
View article: Unmet needs after prevention: a model for managing premature surgical menopause post-risk-reducing bilateral salpingo-oophorectomy
Unmet needs after prevention: a model for managing premature surgical menopause post-risk-reducing bilateral salpingo-oophorectomy Open
Risk-reducing bilateral salpingo-oophorectomy (rrBSO) is a standard of care for individuals with BRCA1/2 pathogenic variants and other hereditary ovarian cancer syndromes. While the oncologic benefits are clear, the abrupt estrogen depriva…
View article: Hemolytic anemia in a child with myelodysplastic syndrome t(6;9)(p22;q34.1)/DEK-NUP214: A case report
Hemolytic anemia in a child with myelodysplastic syndrome t(6;9)(p22;q34.1)/DEK-NUP214: A case report Open
Background: Myelodysplastic syndrome (MDS) is a rare childhood syndrome that accounts for less than 5 % of all pediatric hematologic malignancies. MDS is associated with impaired hematopoiesis with resultant thrombocytopenia, cytopenia, an…
View article: Virtual Versus Reality: Assessing the Accuracy of a Digital Cancer Risk Assessment Tool in a Gynecologic Oncology Clinic
Virtual Versus Reality: Assessing the Accuracy of a Digital Cancer Risk Assessment Tool in a Gynecologic Oncology Clinic Open
View article: EXPLORING THE PERCEPTIONS OF HEALTHCARE PROFESSIONS OF ADVERSE EVENTS REPORTING AND THEIR IMPACT ON PATIENT SAFETY
EXPLORING THE PERCEPTIONS OF HEALTHCARE PROFESSIONS OF ADVERSE EVENTS REPORTING AND THEIR IMPACT ON PATIENT SAFETY Open
View article: Protocol for Health Risk Information Technology-Assisted Genetic Evaluation (HeRITAGE): a randomised controlled trial of digital genetic cancer risk assessment in a diverse underserved gynaecology clinic
Protocol for Health Risk Information Technology-Assisted Genetic Evaluation (HeRITAGE): a randomised controlled trial of digital genetic cancer risk assessment in a diverse underserved gynaecology clinic Open
Introduction In the USA, up to 95% of individuals harbouring cancer-predisposing germline pathogenic variants have not been identified despite recommendations for screening at the primary care level. Methods and analysis Our primary object…
View article: Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort
Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort Open
Prostate cancer is a heritable disease with ancestry-biased incidence and mortality. Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk, including prostate cancer. While their accuracy continues to improve…
View article: Implementation of a smartphone survey and mainstreaming for genetic cancer risk assessment in a diverse, urban, Medicaid-predominant gynecology clinic: a step toward health equity
Implementation of a smartphone survey and mainstreaming for genetic cancer risk assessment in a diverse, urban, Medicaid-predominant gynecology clinic: a step toward health equity Open
View article: Timely Targeted Testing – Importance of Clinician-Facilitated Cascade Testing in the First-Year Post-Diagnosis
Timely Targeted Testing – Importance of Clinician-Facilitated Cascade Testing in the First-Year Post-Diagnosis Open
View article: 428 Cost-effectiveness of BRCA1 testing at time of obstetrical prenatal carrier screening for cancer prevention
428 Cost-effectiveness of BRCA1 testing at time of obstetrical prenatal carrier screening for cancer prevention Open
View article: “Go ahead and screen” - advice to healthcare systems for routine lynch syndrome screening from interviews with newly diagnosed colorectal cancer patients
“Go ahead and screen” - advice to healthcare systems for routine lynch syndrome screening from interviews with newly diagnosed colorectal cancer patients Open
View article: PR001/#687 Pan-gynecologic cancer analysis of somatic homologous recombination deficiency pathogenic gene variants: more prevalent than we think?
PR001/#687 Pan-gynecologic cancer analysis of somatic homologous recombination deficiency pathogenic gene variants: more prevalent than we think? Open
Introduction We conducted a pan-gynecologic cancer analysis of the prevalence of somatic pathogenic gene variants (PGVs) in homologous recombination deficiency (HRD) genes. Methods The American Association for Cancer Research's (AACR) Proj…
View article: Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling
Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling Open
View article: Chatbot Artificial Intelligence for Genetic Cancer Risk Assessment and Counseling: A Systematic Review and Meta-Analysis
Chatbot Artificial Intelligence for Genetic Cancer Risk Assessment and Counseling: A Systematic Review and Meta-Analysis Open
PURPOSE Most individuals with a hereditary cancer syndrome are unaware of their genetic status due to underutilization of hereditary cancer risk assessment. Chatbots, or programs that use artificial intelligence to simulate conversation, h…
View article: Cascade genetic testing in racial and ethnic minorities: Are we Leaving them out? A systematic review and meta-analysis (2130)
Cascade genetic testing in racial and ethnic minorities: Are we Leaving them out? A systematic review and meta-analysis (2130) Open
View article: #1090 The mutational landscape of uterine sarcoma: is there rationale for targeted therapies?
#1090 The mutational landscape of uterine sarcoma: is there rationale for targeted therapies? Open
Introduction/Background We aimed to characterize the mutational landscape of uterine sarcoma. Methodology Data were extracted from the American Association for Cancer Research's (AACR) Project Genomics Evidence Neoplasia Information Exchan…
View article: SO-20 The landscape of homologous recombination deficiency in colorectal cancer
SO-20 The landscape of homologous recombination deficiency in colorectal cancer Open
View article: Underrepresentation of racial and ethnic minorities in cascade testing for hereditary cancer syndromes
Underrepresentation of racial and ethnic minorities in cascade testing for hereditary cancer syndromes Open
View article: A picture is worth a thousand words: advancing the use of visualization tools in implementation science through process mapping and matrix heat mapping
A picture is worth a thousand words: advancing the use of visualization tools in implementation science through process mapping and matrix heat mapping Open
Background Identifying key determinants is crucial for improving program implementation and achieving long-term sustainment within healthcare organizations. Organizational-level complexity and heterogeneity across multiple stakeholders can…
View article: Web-based tool for cancer family history collection: A prospective randomized controlled trial
Web-based tool for cancer family history collection: A prospective randomized controlled trial Open
View article: Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis
Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis Open
View article: EP272/#1143 Partner and localizer of BRCA2 (PALB2) pathogenic variants and ovarian cancer: a systematic review and meta-analysis
EP272/#1143 Partner and localizer of BRCA2 (PALB2) pathogenic variants and ovarian cancer: a systematic review and meta-analysis Open
Objectives Approximately 20% of ovarian cancers are due to an underlying germline pathogenic variant. While several genes have been well-established in the development of hereditary ovarian cancer (e.g. BRCA1/2, RAD51C, RAD51D, BRIP1, mism…
View article: What happens in the long term: Uptake of cancer surveillance and prevention strategies among at‐risk relatives with pathogenic variants detected via cascade testing
What happens in the long term: Uptake of cancer surveillance and prevention strategies among at‐risk relatives with pathogenic variants detected via cascade testing Open
Background Cascade genetic testing for hereditary cancer syndromes offers affected relatives the opportunity to pursue cancer screening and risk‐reducing surgery and thus reduces morbidity and mortality. The purpose of this study was to me…
View article: Barriers to completion of cascade genetic testing: how can we improve the uptake of testing for hereditary breast and ovarian cancer syndrome?
Barriers to completion of cascade genetic testing: how can we improve the uptake of testing for hereditary breast and ovarian cancer syndrome? Open
View article: Coronavirus Disease 2019 Pandemic–related Colorectal Cancer Screening Delays Impact Unscreened Older Adults the Most, But Mitigation Strategies Exist
Coronavirus Disease 2019 Pandemic–related Colorectal Cancer Screening Delays Impact Unscreened Older Adults the Most, But Mitigation Strategies Exist Open
View article: Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis
Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis Open
PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing for hereditary cancer syndromes, providing relatives the opportunity for early detection and prevention of cancer. The current standard is for patients to c…
View article: Room for improvement in capturing cancer family history in a gynecologic oncology outpatient setting
Room for improvement in capturing cancer family history in a gynecologic oncology outpatient setting Open
View article: Economic Evaluation of Universal Lynch Syndrome Screening Protocols among Newly Diagnosed Patients with Colorectal Cancer
Economic Evaluation of Universal Lynch Syndrome Screening Protocols among Newly Diagnosed Patients with Colorectal Cancer Open
We conducted an updated economic evaluation, from a healthcare system perspective, to compare the relative effectiveness and efficiency of eight Lynch syndrome (LS) screening protocols among newly diagnosed colorectal cancer (CRC) patients…
View article: MA09.07 Genomic Landscape and Clinical Outcomes With Immune Checkpoint Inhibitors in NF1-Mutant NSCLC
MA09.07 Genomic Landscape and Clinical Outcomes With Immune Checkpoint Inhibitors in NF1-Mutant NSCLC Open