Ravikanth Appalabhotla
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View article: Optogenetic control of PLC-γ1 activity polarizes cell motility
Optogenetic control of PLC-γ1 activity polarizes cell motility Open
Phospholipase C-γ1 (PLC-γ1) signaling is required for mesenchymal chemotaxis, but is it sufficient to bias motility? PLC-γ1 enzyme activity is basally autoinhibited, and light-controlled membrane recruitment of wild-type (WT) PLC-γ1 (OptoP…
View article: Microfluidic devices fitted with “flowver” paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration
Microfluidic devices fitted with “flowver” paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration Open
Microfluidics approaches have gained popularity in the field of directed cell migration, enabling control of the extracellular environment and integration with live-cell microscopy; however, technical hurdles remain. Among the challenges a…