Ravikumar Nutakki
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View article: Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy
Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy Open
With an objective to improve the profiles of the 1st generation non-basic MCHR1 antagonists, a lean design approach of replacing the bicyclic thienopyrimidine core with a monocyclic pyrrol-2-one chemotype was examined in the context of red…
View article: Therapeutic Potential of Curcumin on Immune Dysregulation in Comorbid Diabetic Asthma in Mice
Therapeutic Potential of Curcumin on Immune Dysregulation in Comorbid Diabetic Asthma in Mice Open
Introduction T helper (Th) cell sub-types work synergistically to balance the immune equilibrium in healthy immune system and the supremacy of T helper 1 (Th1) can down-regulate T helper 2 (Th2) and vice versa [1]. Inequity of Th1/Th2 cell…
View article: Immunomodulatory effect of Quercetin on dysregulated Th1/Th2 cytokine balance in mice with both type 1 diabetes and allergic asthma
Immunomodulatory effect of Quercetin on dysregulated Th1/Th2 cytokine balance in mice with both type 1 diabetes and allergic asthma Open
T-helper subtype imbalance is intricate in type 1 diabetes (T1D) and asthma initiation.The role of quercetin in immune dysregulation in comorbid conditions of T1D and asthma is not available.In this study, it was thought worthy to evaluate…