Ravinder Kaur
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View article: Microbiological profile of healthcare-associated infections at a tertiary care center, New Delhi, India
Microbiological profile of healthcare-associated infections at a tertiary care center, New Delhi, India Open
Objective: To determine the incidence and microbiological profile of healthcare-associated infections (HAIs) in a Medical Intensive Care Unit (MICU) in New Delhi, India. Methods: All patients aged 18 years and above who were admitted to th…
View article: Eighteen-Year Longitudinal Study of Uncomplicated and Complex Acute Otitis Media During the Pneumococcal Conjugate Vaccine Era, 2006–2023
Eighteen-Year Longitudinal Study of Uncomplicated and Complex Acute Otitis Media During the Pneumococcal Conjugate Vaccine Era, 2006–2023 Open
Background We analyzed the demographic and risk factors, middle ear fluid (MEF) pathogens, pneumococcus serotype distribution, and bacterial antibiotic nonsusceptibility among children with uncomplicated acute otitis media (uAOM) and compl…
View article: Anticipated Effects of Higher-valency Pneumococcal Conjugate Vaccines on Colonization and Acute Otitis Media
Anticipated Effects of Higher-valency Pneumococcal Conjugate Vaccines on Colonization and Acute Otitis Media Open
Background: Bacterial etiologies of acute otitis media (AOM) have shifted from the introduction of pneumococcal conjugate vaccines (PCVs), antibiotic selection and competition among species. We characterized Streptococcus pneumoniae ( Spn …
View article: Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways
Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways Open
Background Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunisations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigate…
View article: Serotype 3 Antibody Response and Antibody Functionality Compared to Serotype 19A Following 13-Valent Pneumococcal Conjugate Immunization in Children
Serotype 3 Antibody Response and Antibody Functionality Compared to Serotype 19A Following 13-Valent Pneumococcal Conjugate Immunization in Children Open
Background: Prevention of infections in children vaccinated with 13-valent pneumococcal conjugate vaccine (PCV13) may be less effective against serotype 3 than 19A. Objective: The aim of this study was to to determine differences in IgG an…
View article: 1725. Differences in serotype 3 antibody response and antibody functionality compared to serotype 19A following 13-valent pneumococcal conjugate immunization in children
1725. Differences in serotype 3 antibody response and antibody functionality compared to serotype 19A following 13-valent pneumococcal conjugate immunization in children Open
Background Background. 13-valent pneumococcal conjugate vaccine (PCV13) includes serotype 3 and 19A. However, prevention of infections with PCV13 may be less effective against serotype 3 than 19A. In young children, determine differences i…
View article: 1688. Naturally-induced Serum Antibody Levels in Children to Pneumococcal Polysaccharide 15B that Correlate with Protection from Nasopharyngeal Colonization but Anti-serotype 15B Antibody has Low Functional Cross-reactivity with Serotype 15C.
1688. Naturally-induced Serum Antibody Levels in Children to Pneumococcal Polysaccharide 15B that Correlate with Protection from Nasopharyngeal Colonization but Anti-serotype 15B Antibody has Low Functional Cross-reactivity with Serotype 15C. Open
Background Pneumococcal infections caused by non-vaccine serotypes, including serotype 15B and 15C, emerged after the introduction of pneumococcal conjugate vaccines (PCVs). Serotypes 15B and 15C have been added to new different pneumococc…
View article: Variability of Vaccine Responsiveness in Young Children
Variability of Vaccine Responsiveness in Young Children Open
Background Variability in vaccine responsiveness among young children is poorly understood. Methods Nasopharyngeal secretions were collected in the first weeks of life for measurement of cytokines/chemokines seeking a biomarker, and blood …
View article: Expression conditions and characterization of a novelly constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections
Expression conditions and characterization of a novelly constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections Open
Bacterial lipoproteins are structurally divided into two groups, based on their lipid moieties: diacylated (present in Gram-positive bacteria) and triacylated (present in some Gram-positive and most Gram-negative bacteria). Diacylated and …
View article: Colonization, Density, and Antibiotic Resistance of <i>Streptococcus pneumoniae</i>, <i>Haemophilus Influenzae</i>, and <i>Moraxella catarrhalis</i> among PCV13-Vaccinated Infants in the First Six Months of Life in Rochester, New York: A Cohort Study
Colonization, Density, and Antibiotic Resistance of <i>Streptococcus pneumoniae</i>, <i>Haemophilus Influenzae</i>, and <i>Moraxella catarrhalis</i> among PCV13-Vaccinated Infants in the First Six Months of Life in Rochester, New York: A Cohort Study Open
Background Streptococcus pneumoniae (Spn), Haemophilus influenzae (Hflu), and Moraxella catarrhalis (Mcat) nasopharyngeal colonization precedes disease pathogenesis and varies among settings and countries. We sought to assess colonization …
View article: Window of Susceptibility to Acute Otitis Media Infection
Window of Susceptibility to Acute Otitis Media Infection Open
BACKGROUND Contemporary, quantitative data are needed to inform recommendations and decision-making regarding referral and surgeon endorsement of tympanostomy tube placement in young children with recurrent acute otitis media (AOM). METHOD…
View article: <i>Haemophilus influenzae</i> Protein D antibody suppression in a multi‐component vaccine formulation
<i>Haemophilus influenzae</i> Protein D antibody suppression in a multi‐component vaccine formulation Open
Nontypeable Haemophilus influenzae ( NTHi ) has emerged as a dominant mucosal pathogen causing acute otitis media (AOM) in children, acute sinusitis in children and adults, and acute exacerbations of chronic bronchitis in adults. Consequen…
View article: Lipidation of <i>Haemophilus influenzae</i> Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection
Lipidation of <i>Haemophilus influenzae</i> Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection Open
Nontypeable Haemophilus influenzae (NTHi) causes respiratory infections that lead to high morbidity and mortality worldwide, encouraging development of effective vaccines. To achieve a protective impact on nasopharyngeal (NP) colonization …
View article: Comparative evaluation of cost effective extraction free molecular technique for detection of SARS-CoV-2 with reference to standard VTM based RT-qPCR method
Comparative evaluation of cost effective extraction free molecular technique for detection of SARS-CoV-2 with reference to standard VTM based RT-qPCR method Open
Background and Objectives: The entire globe is undergoing an unprecedented challenge of COVID-19. Considering the need of rapid and accurate diagnostic tests for SARS-CoV-2, this study was planned to evaluate the cost effective extraction …
View article: Transition of Serotype 35B Pneumococci From Commensal to Prevalent Virulent Strain in Children
Transition of Serotype 35B Pneumococci From Commensal to Prevalent Virulent Strain in Children Open
In our community-based prospective cohort study in young children, we observed a significant increase in pneumococcal serotype 35B nasopharyngeal (NP) commensal colonization during the 2011–2014 timeframe, but these strains were not associ…
View article: COVID-19 Pandemic Impact on Respiratory Infectious Diseases in Primary Care Practice in Children
COVID-19 Pandemic Impact on Respiratory Infectious Diseases in Primary Care Practice in Children Open
Background: The coronavirus disease 2019 (COVID-19) pandemic led to day care and school closures and children staying home for several months. When they gradually returned, aggressive regulations were implemented in New York State to reduc…
View article: Evaluation of Rifampicin-resistant Tuberculosis in Pediatric Patients by GeneXpert MTB/RIF
Evaluation of Rifampicin-resistant Tuberculosis in Pediatric Patients by GeneXpert MTB/RIF Open
Objectives: India has the largest burden of MDR-TB worldwide, with an annual incidence of 1,30 000 patients. Multidrug-resistant tuberculosis (MDR-TB) carries a poor prognosis, a high mortality rate, and treatment success rates as low as 6…
View article: Changing Pattern of Resistance in Typhoid Fever in An Era of Antimicrobial Resistance: Is It Time to Revisit Treatment Strategies?
Changing Pattern of Resistance in Typhoid Fever in An Era of Antimicrobial Resistance: Is It Time to Revisit Treatment Strategies? Open
Objectives: Multi-drug-resistant Salmonella Typhi is a major concern in the current era of antimicrobial resistance. The emergence of ceftriaxone-resistant Salmonella Typhi strains (CRST) has left very few therapeutic options for the treat…
View article: Guiding Antimicrobial Therapy using Gram Stain in Patients with Ventilator Associated Pneumonia- An Effective Preliminary Diagnostic Tool
Guiding Antimicrobial Therapy using Gram Stain in Patients with Ventilator Associated Pneumonia- An Effective Preliminary Diagnostic Tool Open
Introduction: Empirical antimicrobial therapy is the mainstay of antimicrobial stewardship. The gram stain can be used to guide initial empiric antimicrobial therapy in cases where culture report is not available. This rapid test can there…
View article: Throat Carriage of Staphylococcus aureus
Throat Carriage of Staphylococcus aureus Open
Staphylococcus aureus is colonized in anterior nares, throat, axilla, groin, pharynx and gastrointestinal tract and damaged skin surface. Colonization provides a reservoir from which bacteria can be introduced in the body in immunocompromi…
View article: Comparison of pneumococcal conjugate vaccine (PCV-13) cellular immune responses after primary and booster doses of vaccine
Comparison of pneumococcal conjugate vaccine (PCV-13) cellular immune responses after primary and booster doses of vaccine Open
Since their widespread use, pneumococcal conjugate vaccines (PCVs) have proven effective at reducing both invasive and noninvasive pneumococcal diseases and nasopharyngeal carriage of Streptococcus pneumoniae (Spn). To establish this level…
View article: Comparative Evaluation of GeneXpert MTB/RIF Assay and Microscopy for Rapid Diagnosis of Tuberculous Meningitis in Children
Comparative Evaluation of GeneXpert MTB/RIF Assay and Microscopy for Rapid Diagnosis of Tuberculous Meningitis in Children Open
Tuberculous meningitis (TBM) is the most devastating complication of Mycobacterium tuberculosis infection. Diagnosis of TBM is challenging in young children due to the paucibacillary nature of disease. Microscopy for acid-fast bacilli in C…
View article: Rising Pneumococcal Antibiotic Resistance in the Post–13-Valent Pneumococcal Conjugate Vaccine Era in Pediatric Isolates From a Primary Care Setting
Rising Pneumococcal Antibiotic Resistance in the Post–13-Valent Pneumococcal Conjugate Vaccine Era in Pediatric Isolates From a Primary Care Setting Open
Background Antibiotic-resistant Streptococcus pneumoniae strains may cause infections that fail to respond to antimicrobial therapy. Results reported from hospitalized patients with invasive, bacteremic infections may not be the same as th…
View article: Anti‐EF‐Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen <i>Haemophilus influenzae</i>
Anti‐EF‐Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen <i>Haemophilus influenzae</i> Open
Non‐typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmon…
View article: Myroides spp. Causing Urinary Tract Infection in an Immunocompromised Patient: A Case Report
Myroides spp. Causing Urinary Tract Infection in an Immunocompromised Patient: A Case Report Open
Myroides spp. have historically been rare opportunistic pathogens although present widely in nature. Their notorious resistance to most classes of antibacterials and invasive potential leading to serious infections among the immunocompromi…
View article: Gastric adenomyoma: a case report
Gastric adenomyoma: a case report Open
Upper gastrointestinal (GI) bleeding is usually seen secondary to esophageal varices or peptic ulcer disease, but at times, unusual causes can be encountered. We present one such case of a young 30-year-old gentleman who presented with rec…