Explanipedia

Author Correction: Pathogen genomic surveillance status among lower resource settings in Asia Open

Marya Getchell, Suci Wulandari, Ruklanthi de Alwis, Shreya Agoramurthy, Yoong Khean Khoo , et al. · 2024

Pathogen genomic surveillance status among lower resource settings in Asia Open

Marya Getchell, Suci Wulandari, Ruklanthi de Alwis, Shreya Agoramurthy, Yoong Khean Khoo , et al. · 2024

Cross-sectional study of influenza trends and costs in Malaysia between 2016 and 2018 Open

Sharifa Ezat Wan Puteh, Mohd Shafiq Aazmi, Muhammad Nazri Aziz, Noor ‘Adilah Kamarudin, Jamal I-Ching Sam , et al. · 2024

Background and objectives While influenza circulates year-round in Malaysia, research data on its incidence is scarce. Yet, this information is vital to the improvement of public health through evidence-based policies. In this cross-sectio…

Correction: RNA purification-free detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP) Open

Meng Yee Lai, Jeyanthi Suppiah, Ravindran Thayan, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2023

The seroprevalence of SARS‐CoV‐2 infection in Malaysia: 7 August to 11 October 2020 Open

Zhuo Lin Chong, Wan Shakira Rodzlan Hasani, Filza Noor Asari, Eida Nurhadzira Muhammad, Mohd Hatta Abdul Mutalip , et al. · 2023

Background From the beginning of the COVID‐19 pandemic until mid‐October 2020, Malaysia recorded ~15,000 confirmed cases. But there could be undiagnosed cases due mainly to asymptomatic infections. Seroprevalence studies can better quantif…

Corrigendum to “Colorimetric detection of SARS-CoV-2 by uracil-DNA glycosylase (UDG) reverse transcription loop-mediated isothermal amplification (RT-LAMP)” [International Journal of Infectious Diseases 120 (2023) Pages 132-134] Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2023

The authors regret the Acknowledgement statement was incorrect in the published version of this article. The correct Acknowledgement statement is as follows: Acknowledgments: This study was supported by Prototype Research Grant Scheme (PRG…

In Vitro Anti-SARS-CoV-2 Activities of Curcumin and Selected Phenolic Compounds Open

Mohd Ridzuan Mohd Abd Razak, Nur Hana Md Jelas, Amirrudin Muhammad, Noorsofiana Padlan, Muhammad Nor Farhan Sa’at , et al. · 2023

Since the COVID-19 pandemic in 2020, many reports have highlighted several potential anti-SARS-CoV-2 drug candidates, including phenolic compounds. Therefore, this study aimed to evaluate the anti-SARS-CoV-2 activity of nine common phenoli…

Resurgence of Dengue Virus Serotype 4 in Malaysia: A Comprehensive Clinicodemographic and Genomic Analysis Open

Jeyanthi Suppiah, Ernie Zuraida Ali, Mohd Khairul Nizam Mohd Khalid, Sumarni Mohd Ghazali, Kok Keng Tee , et al. · 2023

Dengue virus serotype 4 (DENV-4) has been the rarest circulating serotype in Malaysia, resulting in it being an understudied area. A recent observation from institutional surveillance data indicated a rapid increase in DENV-4-infected case…

COVID-19 SEROPREVALENCE STUDY AMONG MALAYSIA'S GENERAL POPULATION UP TO EARLY OCTOBER 2020 Open

Zhuo Lin Chong, Wan Shakira Rodzlan Hasani, Ravindran Thayan, Mohd Hatta Abdul Mutalip · 2023

Intro: Coronavirus disease 2019 (COVID-19) began spreading in Malaysia since February 2020. Within months, the epidemic curve was flattened through strict public health measures and the number of confirmed cases remained low. But actual di…

Vero CCL-81 and Calu-3 Cell Lines as Alternative Hosts for Isolation and Propagation of SARS-CoV-2 Isolated in Malaysia Open

Siti Nur Zawani Rosli, Sitti Rahmawati Dimeng, Farah Shamsuddin, Mohammad Ridhuan Mohd Ali, Nur Afrina Muhamad Hendri , et al. · 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the etiologic agent for the pneumonia outbreak that started in early December 2019 in Wuhan City, Hubei Province, China. To date, coronavirus disease (COVI…

IN VIVO ANTI-DENGUE STUDY OF SCHIZOPHYLLUM COMMUNE AQUEOUS EXTRACT IN AG129 MICE Open

Kavithambigai Ellan, Mohd Ridzuan Mohd Abd Razak, A. Muhammad, Nur Hana Md Jelas, Muhammad Farhan , et al. · 2023

Intro: An effective antiviral therapies are currently unavailable for the treatment of DENV infection. Schizophyllum commune aqueous extract (ScASE) had been reported for the anti-dengue effect in in-vitro studies using plaque reduction as…

The Use of Casemix System to Estimate Providers` Inpatients’ Cost of Influenza Related Sari Diseases in Malaysia Open

Sharifa Ezat Wan Puteh, Noor ‘Adilah Kamarudin, S Nasir, Wan Noraini Wan Mohamed Noor, Zamberi Sekawi , et al. · 2023

Introduction: Influenza is an upper respiratory infection is caused by the influenza virus. It occurs throughout the whole year in Malaysia with occasional outbreaks. Influenza-like illnesses (ILI) are generally treated as outpatient care …

SARS-CoV-2 genomic surveillance in Malaysia: displacement of B.1.617.2 with AY lineages as the dominant Delta variants and the introduction of Omicron during the fourth epidemic wave Open

Nor Azila Muhammad Azami, David Perera, Ravindran Thayan, Sazaly AbuBakar, I‐Ching Sam , et al. · 2022

Clinical testing on SARS-CoV-2 swab samples using reverse-transcription loop-mediated isothermal amplification (RT-LAMP) Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2022

Colorimetric detection of SARS-CoV-2 by uracil-DNA glycosylase (UDG) reverse transcription loop-mediated isothermal amplification (RT-LAMP) Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2022

RNA purification-free detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP) Open

Meng Yee Lai, Jeyanthi Suppiah, Ravindran Thayan, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2022

Background Current diagnosis of SARS-CoV-2 infection relies on RNA purification prior to amplification. Typical extraction methods limit the processing speed and turnaround time for SARS-CoV-2 diagnostic testing. Methods Here, we applied r…

Two extraction-free reverse transcription loop-mediated isothermal amplification assays for detection of SARS-CoV-2 Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2021

Human airway epithelial Calu-3 cells as the potential platform to study the pathophysiology of SARS-CoV-2 isolated in Malaysia Open

Siti Nur Zawani Rosli, Sitti Rahmawati Dimeng, Farah Shamsuddin, Mohammad Ridhuan Mohd Ali, Nur Afrina Muhamad Hendri , et al. · 2021

Immunomodulatory Activities of Carica papaya L. Leaf Juice in a Non-Lethal, Symptomatic Dengue Mouse Model Open

Mohd Ridzuan Mohd Abd Razak, Nor Azrina Norahmad, Nur Hana Md Jelas, Adlin Afzan, Norazlan Mohmad Misnan , et al. · 2021

The role of Carica papaya L. leaf juice in immune dysregulation caused by dengue virus infection remains unclear. This study aimed to investigate the immunomodulatory activities of the freeze-dried C. papaya leaf juice (FCPLJ) on AG129 mic…

COVID‐19 screening test by using random oropharyngeal saliva Open

Mohan Rao, Fairuz Abdul Rashid, Fashihah S. A. H. Sabri, Nur Nadia Jamil, Valentinus H. Seradja , et al. · 2021

An optimal clinical specimen for accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by minimizing the usage of consumables and reduce hazard exposure to healthcare workers is an urgent priority. The diagnost…

Direct Detection of SARS-CoV-2 Using Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) Without RNA Purification Open

Meng Yee Lai, Fatma Diyana Mohd Bukhari, Nur Zulaikha Zulkefli, Ilyiana Ismail, Nur Izati Mustapa , et al. · 2021

Acute Encephalitis Associated with SARS-CoV-2 Confirmed in Cerebrospinal Fluid: First Case in Malaysia Open

Tze Yuan Tee, Alif Adlan Mohd Thabit, Ching Soong Khoo, Hisham Md Shahrom, En Ze Chan , et al. · 2021

A 69-year-old male with hypertension and atrial fibrillation presented with a 4-day history of fever, cough, and breathlessness, and subsequently developed disorientation and confusion for 1 day. On arrival, his Glasgow Coma Scale was 12/1…

Whole Genome Sequence Analysis of SARS-CoV-2 Strains Circulating in Malaysia During First Wave and Early Second Wave of Infections. Open

Zarina Mohd Zawawi, Jeyanthi Suppiah, Jeevanathan Kalyanasundram, Muhammad Afif Azizan, Shuhaila Mat-Sharani , et al. · 2020

Background : Since December 2019, the outbreak of COVID-19 has raised a great public health concern globally. Here, we report the whole genome sequencing analysis of SARS-CoV-2 strains in Malaysia isolated from six patients diagnosed with …

SARS-CoV-2 Viral Outbreak Investigation: Laboratory Perspective Open

Cheng Hoon Chew, Yan Yee Yip, Ming Tsuey Lim, Weng Kiong Lee, Hani Mat Hussin , et al. · 2020

This book contains transcript from the live webinar "Clinical Updates in COVID-19" organized by Institute for Clinical Research, NIH Malaysia on 2nd of July 2020. There are 3 panellists and 2 presentations in this webinar focusing on: Scal…

Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study Open

Kavithambigai Ellan, Ravindran Thayan, Jegadeesh Raman, Kazuya I.P.J. Hidari, I Norizah , et al. · 2019

Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice Open

Mohd Ridzuan Mohd Abd Razak, Nor Azrina Norahmad, Nur Hana Md Jelas, Bazilah Jusoh, Amirrudin Muhammad , et al. · 2019

Zika virus infection in Malaysia: an epidemiological, clinical and virological analysis Open

Yuan Liang Woon, Mei Fong Lim, Tg Rogayah Tg Abd Rashid, Ravindran Thayan, Suresh Kumar Chidambaram , et al. · 2019

Despite similar ecological background characteristics, Malaysia was not as affected by the recent ZIKV outbreak compared to Brazil and Singapore. This could be related to pre-existing immunity against ZIKV in this population, which develop…

Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice Open

Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu , et al. · 2019

The findings indicated the possible immunomodulatory role of FCPLJ during dengue virus infection in AG129 mice.

Postmortem evidence of disseminated Zika virus infection in an adult patient Open

Giri Shan Rajahram, Gillian Hale, Julu Bhatnagar, Jessie Hiu, Ravindran Thayan , et al. · 2019

Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associate…

The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model Open

Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Nor Azrina Norahmad, Amirrudin Muhammad , et al. · 2018

Oral treatment of 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ at the onset of viremia did not affect the plasma NS1 and viral RNA levels in AG129 mice infected with non-mouse adapted New Guinea C strain dengue virus.

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