Raya Saab
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View article: Adaptive Clinical Neuroblastoma Risk Groups—Tailoring Treatment in Low- and Middle-Income Countries: An International Neuroblastoma Risk Group Project
Adaptive Clinical Neuroblastoma Risk Groups—Tailoring Treatment in Low- and Middle-Income Countries: An International Neuroblastoma Risk Group Project Open
PURPOSE Risk/treatment stratification for children with neuroblastoma (NB) relies on clinical, histologic, and genomic factors. However, most children with cancer live in low- and middle-income countries (LMIC), where access to advanced me…
View article: Aggressive Pediatric Primitive Round Cell Tumors with <i>MN1</i>::<i>ZNF341</i> Fusion: A Mimic of Neuroblastoma
Aggressive Pediatric Primitive Round Cell Tumors with <i>MN1</i>::<i>ZNF341</i> Fusion: A Mimic of Neuroblastoma Open
Neuroblastoma is one of the most common tumors in young children, arising from the adrenal medulla or paraspinal sympathetic ganglia. We describe primitive round cell tumors presenting in three patients less than 1.5 years old, with striki…
View article: Single-Cell Fluidic Force Spectroscopy Reveals Dynamic Mechanical Fingerprints of Malignancy in Breast Cancer
Single-Cell Fluidic Force Spectroscopy Reveals Dynamic Mechanical Fingerprints of Malignancy in Breast Cancer Open
The interplay between cancer cell physical characteristics and metastatic potential highlights the significance of cancer cell mechanobiology. Using fluidic-based single-cell force spectroscopy (SCFS), quartz crystal microbalance with diss…
View article: Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma
Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma Open
Rhabdomyosarcoma is a pediatric cancer associated with aggressiveness and a tendency to develop metastases. Fusion-negative rhabdomyosarcoma (FN-RMS) is the most commonly occurring subtype of RMS, where metastatic disease can hinder treatm…
View article: Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial
Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial Open
Background Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomi…
View article: A regional virtual case discussion forum in pediatric oncology: Experience of the Pediatric Oncology East and Mediterranean Group
A regional virtual case discussion forum in pediatric oncology: Experience of the Pediatric Oncology East and Mediterranean Group Open
Background The Pediatric Oncology East and Mediterranean (POEM) group that aims to share expertise among pediatric oncology providers across the Middle East, North Africa, and East Asia region initiated a virtual Case Discussion Forum (CDF…
View article: Prospective External Validation of the Esbenshade Vanderbilt Models Accurately Predicts Bloodstream Infection Risk in Febrile Non-Neutropenic Children With Cancer
Prospective External Validation of the Esbenshade Vanderbilt Models Accurately Predicts Bloodstream Infection Risk in Febrile Non-Neutropenic Children With Cancer Open
PURPOSE The optimal management of fever without severe neutropenia (absolute neutrophil count [ANC] ≥500/µL) in pediatric patients with cancer is undefined. The previously proposed Esbenshade Vanderbilt (EsVan) models accurately predict ba…
View article: Development of EPAT: An assessment tool for pediatric hematology/oncology training programs
Development of EPAT: An assessment tool for pediatric hematology/oncology training programs Open
Purpose In the absence of a standardized tool to assess the quality of pediatric hematology/oncology training programs, the Education Program Assessment Tool (EPAT) was conceptualized as a user‐friendly and adaptable tool to evaluate and i…
View article: Supplementary Figures 1-7 from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor
Supplementary Figures 1-7 from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor Open
Supplementary Figures 1-7 from p18Ink4c and p53 Act as Tumor Suppressors in Cyclin D1–Driven Primitive Neuroectodermal Tumor
View article: Supplementary Figures 1-7 from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor
Supplementary Figures 1-7 from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor Open
Supplementary Figures 1-7 from p18Ink4c and p53 Act as Tumor Suppressors in Cyclin D1–Driven Primitive Neuroectodermal Tumor
View article: Data from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor
Data from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor Open
The retinoblastoma (RB) tumor suppressor pathway is likely important in primitive neuroectodermal tumors (PNET) of the brain. In fact, 10% to 15% of children born with RB mutations develop brain PNETs, commonly in the pineal gland. Cyclin …
View article: Data from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor
Data from <i>p18<sup>Ink4c</sup></i> and <i>p53</i> Act as Tumor Suppressors in <i>Cyclin D1</i>–Driven Primitive Neuroectodermal Tumor Open
The retinoblastoma (RB) tumor suppressor pathway is likely important in primitive neuroectodermal tumors (PNET) of the brain. In fact, 10% to 15% of children born with RB mutations develop brain PNETs, commonly in the pineal gland. Cyclin …
View article: Addressing the Gap in Research Methodologies Education in Pediatric Oncology in the Eastern Mediterranean Region
Addressing the Gap in Research Methodologies Education in Pediatric Oncology in the Eastern Mediterranean Region Open
PURPOSE Formal training in clinical research methodologies is limited in limited-resource countries. Through collaboration among high- and middle-resource settings and in response to an identified need verbalized by regional pediatric onco…
View article: A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements
A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements Open
Pediatric pineoblastomas (PBs) are rare and aggressive tumors of grade IV histology. Although some oncogenic drivers are characterized, including germline mutations in RB1 and DICER1, the role of epigenetic deregulation and cis -regulatory…
View article: Non-coding RNA in rhabdomyosarcoma progression and metastasis
Non-coding RNA in rhabdomyosarcoma progression and metastasis Open
Rhabdomyosarcoma (RMS) is a soft tissue sarcoma of skeletal muscle differentiation, with a predominant occurrence in children and adolescents. One of the major challenges facing treatment success is the presence of metastatic disease at th…
View article: CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma
CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma Open
Rhabdomyosarcoma (RMS) is an aggressive childhood soft-tissue tumor, with propensity for local invasion and distant metastasis. Exosomes are secreted vesicles that mediate paracrine signaling by delivering functional proteins and miRNA to …
View article: DIPG-25. Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma: a report from the International Diffuse Intrinsic Pontine Glioma Registry
DIPG-25. Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma: a report from the International Diffuse Intrinsic Pontine Glioma Registry Open
BACKGROUND: There are no standard practice guidelines for cerebrospinal (CSF) diversion for diffuse intrinsic pontine glioma (DIPG), nor clear understanding of potential for palliation and life-prolongation. We evaluated CSF diversion char…
View article: Cancer Registration in the Middle East, North Africa, and Turkey: Scope and Challenges
Cancer Registration in the Middle East, North Africa, and Turkey: Scope and Challenges Open
PURPOSE National cancer control strategies have been identified as essential tools for reducing and managing the growing burden of cancer in low- and middle-income countries. Cancer registration is an instrumental component of any cancer c…
View article: Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis (Review)
Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis (Review) Open
Extraskeletal Ewing sarcoma (EES) is a relatively uncommon primary tumor of the soft tissues, which accounts for 20-30% of all reported cases of ES. Being uncommon, all members of the ES family tumors are treated following the same general…
View article: Treatment Induced Cerebral Sinus Venous Thrombosis in Childhood Acute Lymphoblastic Leukemia: New Risk Factors to Consider
Treatment Induced Cerebral Sinus Venous Thrombosis in Childhood Acute Lymphoblastic Leukemia: New Risk Factors to Consider Open
Background: Cerebral Sinus Venous Thrombosis (CSVT) is one of many side effects encountered during acute lymphoblastic leukemia (ALL) therapy. Due to the rarity of cases, lack of data, consensus management, no recommendations exist to targ…
View article: DIPG-74. RE-IRRADIATION OF DIPG: DATA FROM THE INTERNATIONAL DIPG REGISTRY
DIPG-74. RE-IRRADIATION OF DIPG: DATA FROM THE INTERNATIONAL DIPG REGISTRY Open
PURPOSE To review data from DIPG Registry patients recorded to have received a second course of radiation therapy (rRT). METHODS The International DIPG Registry was searched for patients with DIPG who were treated with a known dose of rRT.…
View article: DIPG-55. PATTERNS OF CEREBROSPINAL FLUID DIVERSION AND SURVIVAL IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY
DIPG-55. PATTERNS OF CEREBROSPINAL FLUID DIVERSION AND SURVIVAL IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY Open
There is no standard of care for cerebrospinal (CSF) diversion in children with diffuse intrinsic pontine glioma (DIPG), nor understanding of survival impact. We evaluated CSF diversion characteristics in children with DIPG to determine in…
View article: Effects of the Oncoprotein PAX3-FOXO1 on Modulation of Exosomes Function and Protein Content: Implications on Oxidative Stress Protection and Enhanced Plasticity
Effects of the Oncoprotein PAX3-FOXO1 on Modulation of Exosomes Function and Protein Content: Implications on Oxidative Stress Protection and Enhanced Plasticity Open
Rhabdomyosarcoma (RMS) is a highly malignant soft tissue sarcoma classified into two major histologic subtypes: embryonal (ERMS) and alveolar (ARMS). ARMS subtype is clinically more aggressive, and characterized by an oncogenic fusion prot…
View article: Circulating Tumor Cell Detection Technologies and Clinical Utility: Challenges and Opportunities
Circulating Tumor Cell Detection Technologies and Clinical Utility: Challenges and Opportunities Open
The potential clinical utility of circulating tumor cells (CTCs) in the diagnosis and management of cancer has drawn a lot of attention in the past 10 years. CTCs disseminate from tumors into the bloodstream and are believed to carry vital…
View article: Impact of the coronavirus disease 2019 (COVID‐19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group
Impact of the coronavirus disease 2019 (COVID‐19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group Open
Background Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID‐19) pandemic on access to care for children with cancer is likely …
View article: The Pediatric Oncology East and Mediterranean (POEM) group – A regional collaborative platform for childhood cancer healthcare professionals
The Pediatric Oncology East and Mediterranean (POEM) group – A regional collaborative platform for childhood cancer healthcare professionals Open
The Pediatric Oncology East and Mediterranean (POEM) group was established in 2013 as a cooperative platform for physicians, scientists and healthcare professionals from institutions in the East and Mediterranean area with the goal of shar…