Chiang‐Shan R. Li
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View article: A randomized pilot sleep and circadian behavior clinical trial to improve glycemic and psychological outcomes in young adults with type 1 diabetes (NCT04975230)
A randomized pilot sleep and circadian behavior clinical trial to improve glycemic and psychological outcomes in young adults with type 1 diabetes (NCT04975230) Open
Future research should confirm these preliminary findings in larger, more diverse samples with varied intervention lengths and a longer-term follow-up.
View article: Cingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women
Cingulate and frontopolar cortical projections to the cerebellar vermis support prolonged reaction time in identifying negative emotional scenes in women Open
View article: Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis
Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis Open
Cognitive impairment is a core characteristic of schizophrenia. Immunosenescence has been consistently implicated in the cognitive dysfunction observed in neurodegenerative diseases, but how it may relate to cognitive deficits in schizophr…
View article: Functional Inputs to the Subgenual Cingulate Cortex Distinguish Neurotypical Individuals with Severe and Mild Depressive Problems: Granger Causality and Clustering Analyses
Functional Inputs to the Subgenual Cingulate Cortex Distinguish Neurotypical Individuals with Severe and Mild Depressive Problems: Granger Causality and Clustering Analyses Open
Extant research has implicated functional connectivity of the subgenual anterior cingulate cortex (sgACC) in major depressive disorders or depressive traits in neurotypical populations. However, prior studies have not distinguished the inp…
View article: A Randomized Pilot Cognitive Behavioral Sleep Health Trial for Young Adults with Type 1 Diabetes
A Randomized Pilot Cognitive Behavioral Sleep Health Trial for Young Adults with Type 1 Diabetes Open
Longer sleep duration, higher daytime alertness, and sustained sleep efficiency are possible with this CB-Sleep Health intervention in young adults managing a complex condition.
View article: Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder Open
Studies of brain morphology in mental illness often incompletely characterize structural variation, focusing on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder …
View article: Gray Matter Volumes of the Superior Temporal Gyrus Link Preterm Birth and Developmentally Disordered Eye Gazing Patterns in Toddlers at Eighteen Months
Gray Matter Volumes of the Superior Temporal Gyrus Link Preterm Birth and Developmentally Disordered Eye Gazing Patterns in Toddlers at Eighteen Months Open
Background Preterm birth involves structural brain changes and increases the risk of neurodevelopmental disorders, including social cognitive dysfunction as implicated in autism spectrum disorder (ASD). However, it remains unclear whether …
View article: Wearable Intervention for Alcohol Use Risk and Sleep in Young Adults
Wearable Intervention for Alcohol Use Risk and Sleep in Young Adults Open
Importance Young adults in the US have the highest prevalence of alcohol use disorder; technology-based interventions may help to reduce drinking. Objective To test the efficacy of a multimodal digital intervention of wearable feedback and…
View article: Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults
Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults Open
These findings highlight the influence of genetic risks for depression on neural responses to reward and punishment and provide insights into genetically informed markers of depression.
View article: The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults
The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults Open
Introduction Genetic factors contribute to alcohol misuse. Chronic alcohol consumption is associated with decreases in gray matter volumes (GMVs) of the brain. However, it remains unclear whether or how genetic risks may alter GMVs indepen…
View article: 512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures
512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures Open
Objectives/Goals: Obesity has been classified as a global epidemic and origin of numerous health issues. The central hypothesis of this study is that psychological measures, DNA methylation, and gene transcription will predict obesity-rela…
View article: Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking
Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking Open
The connectomics of white matter FA can predict the severity of alcohol consumption, and by incorporating brain network pathways, identify sex differences. This approach provides new clues to the biological basis of alcohol abuse and evalu…
View article: Imaging Markers of Neuroinflammation in Aging and Alzheimer's Disease and Related Dementia: A Narrative Review
Imaging Markers of Neuroinflammation in Aging and Alzheimer's Disease and Related Dementia: A Narrative Review Open
Neuroinflammation represents a crucial pathophysiological process of cognitive decline during aging and may play an important role in the development of Alzheimer’s disease and related dementia (ADRD). Many magnetic resonance imaging (MRI)…
View article: Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers Open
Drinking as a coping method in response to pain is a complex behaviour, involving multiple neural, motivational, and psychological factors. Among these factors, pain sensitivity and pain‐related drinking motive can significantly promote al…
View article: Cingulate and Frontopolar Cortical Projections to the Cerebellar Vermis Support Prolonged Reaction Time in Identifying Negative Emotional Scenes in Women
Cingulate and Frontopolar Cortical Projections to the Cerebellar Vermis Support Prolonged Reaction Time in Identifying Negative Emotional Scenes in Women Open
We previously observed sex differences in the association of individual anxiety and reaction time (RT) during identification of negative emotional scenes in a Hariri task. Prolonged RT in identifying negative (vs. neutral) images represent…
View article: Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults
Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults Open
View article: The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults
The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults Open
Genetic factors contribute to alcohol misuse. Chronic alcohol consumption is associated with decreases in gray matter volumes (GMVs) of the brain. However, it remains unclear whether or how genetic risks may alter GMVs independent of the e…
View article: Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults Open
Background: Genetic variants may confer risk for depression by modulating brain structure and function; evidence has underscored the key role of the subgenual anterior cingulate cortex (sgACC) in depression. We sought to examine how the re…
View article: Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers Open
View article: <i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
<i>N</i>-Methyl-<span>d</span>-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia Open
Background and Hypothesis Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, …
View article: Impulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression
Impulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression Open
Objective: The independent rôle of impulsivity in alcoholism patient’s suicidality is less elucidated. In this study, we intended to investigate how impulsivity and depression contribute to suicidality in patients with alcohol use disorder…
View article: Hypothalamic connectivities and self-evaluated aggression in young adults
Hypothalamic connectivities and self-evaluated aggression in young adults Open
Introduction The hypothalamus plays a pivotal role in supporting motivated behavior, including aggression. Previous work suggested differential roles of the medial hypothalamus (MH) and lateral hypothalamus (LH) in aggressive behaviors, bu…
View article: Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study
Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study Open
We characterized sex-specific hypothalamic connectivities in link with the severity of alcohol misuse and its comorbidities. These findings extend the literature by elucidating the potential impact of problem drinking on the motivation cir…
View article: Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking Open
Physical pain and negative emotions represent two distinct drinking motives that contribute to harmful alcohol use. Proactive avoidance, in contrast, can reduce consumption in response to these motives but appears to be impaired in those w…
View article: Age-related reduction in anxiety and neural encoding of negative emotional memory
Age-related reduction in anxiety and neural encoding of negative emotional memory Open
Introduction Older adults experience less anxiety. We examined how memory of negative emotional images varied with age and may reflect age-related differences in anxiety. Methods Fifty-one adults, age 22-80 years, underwent imaging with a …
View article: Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia Open
View article: Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory
Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory Open
Alcohol misuse may involve higher DLPFC activation in functional compensation, whereas, in women only, sleep deficiency affects 2-back memory by depressing SC activity. In women only, path model suggests inter-related impact of drinking se…
View article: Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking
Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking Open
Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to reward and punishment and the molecular profiles of the connectivity features predicting alcohol use severity in …
View article: Premature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis
Premature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis Open
This meta-analysis reveals that women with POI have an increased risk of depression, anxiety, and poor life quality. The marital status of POI may be a possible influencing factor for depression, meaning that the unmarried status in POI is…
View article: Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders Open
Background Many studies showed disrupted tryptophan metabolism in patients with affective disorders. The aims of this study were to explore the differences in the metabolites of tryptophan pathway (TP) and the relationships between TP meta…