Ray McLaughlin
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View article: Effect of sarcopenia on treatment response and operative and oncological outcomes among patients undergoing neoadjuvant chemotherapy for breast cancer.
Effect of sarcopenia on treatment response and operative and oncological outcomes among patients undergoing neoadjuvant chemotherapy for breast cancer. Open
Sarcopenia was not associated with clinicopathological parameters and did not affect the response to NAC nor postoperative complications. Lower lean body mass was associated with reduced overall and invasive disease-free survival in patien…
View article: Evaluating the Necessity for Routine Sentinel Lymph Node Biopsy in Postmenopausal Patients Being Treated for Clinically Node Negative Breast Cancer the Era of RxPONDER
Evaluating the Necessity for Routine Sentinel Lymph Node Biopsy in Postmenopausal Patients Being Treated for Clinically Node Negative Breast Cancer the Era of RxPONDER Open
Omitting SLNB may be safe and justifiable in postmenopausal patients with ER+/HER2- breast cancer with clinically negative axillae. Following RxPONDER, RS is the most important guide of chemotherapy use in these patients and SLNB may be le…
View article: A Novel Surrogate Nomogram Capable of Predicting OncotypeDX Recurrence Score©
A Novel Surrogate Nomogram Capable of Predicting OncotypeDX Recurrence Score© Open
Background: OncotypeDX Recurrence Score© (RS) is a commercially available 21-gene expression assay which estimates prognosis and guides chemoendocrine prescription in early-stage estrogen-receptor positive, human epidermal growth factor re…
View article: AB150. SOH22ABS120. Surgical management of estrogen receptor positive breast cancer in the West of Ireland
AB150. SOH22ABS120. Surgical management of estrogen receptor positive breast cancer in the West of Ireland Open
Background: Estrogen receptor positive (ER+) breast cancer accounts for 70–80% of new diagnoses. The cornerstone of breast cancer management involves surgical resection, with judicious use of chemoendocrine and radiotherapies.
View article: AB006. SOH22ABS118. Neoadjuvant chemotherapy prescription in estrogen receptor positive breast cancer in the west of Ireland
AB006. SOH22ABS118. Neoadjuvant chemotherapy prescription in estrogen receptor positive breast cancer in the west of Ireland Open
Background: Estrogen receptor positive (ER+) breast cancers is a hormone sensitive disease, response well to endocrine therapies and carry favourable prognoses. Recently, there has been a vogue to prescribe neoadjuvant chemotherapy (NACT) …
View article: AB079. SOH22ABS128. Receptor change on residual disease following neoadjuvant therapies for locally advanced breast cancer fails to impact oncological and survival outcomes
AB079. SOH22ABS128. Receptor change on residual disease following neoadjuvant therapies for locally advanced breast cancer fails to impact oncological and survival outcomes Open
Background: Conventional breast cancer patient management involves prescription of neoadjuvant therapies (NAT). The aim of this study was to evaluate the rate of receptor status change following NAT and to determine the impact of these cha…
View article: AB009. SOH22ABS142. OncotypeDX© use in patients diagnosed with early-stage estrogen receptor positive breast cancer
AB009. SOH22ABS142. OncotypeDX© use in patients diagnosed with early-stage estrogen receptor positive breast cancer Open
Background: Estrogen receptor positive (ER+) breast cancer is the most common breast cancer molecular subtype. In recent times, the OncotypeDX© Recurrence Score (RS) predicts response to chemoendocrine therapies in early-stage ER+ breast c…
View article: AB004. SOH22ABS111. Relapse patterns in estrogen receptor positive breast cancer
AB004. SOH22ABS111. Relapse patterns in estrogen receptor positive breast cancer Open
Background: Estrogen receptor positive (ER+) breast cancer is the most common breast cancer molecular subtype. The natural history of ER+ breast cancer involves good prognoses, however, when recurrences occur, they are associated with poor…
View article: Breast cancer recurrence: factors impacting occurrence and survival
Breast cancer recurrence: factors impacting occurrence and survival Open
Background Breast cancer mortality has decreased due to improved screening and treatment options. Nevertheless, 25–30% of patients develop disease recurrence and die from the disease dissemination. Patients who develop metastatic disease r…
View article: Schwannoma of the Appendix Orifice
Schwannoma of the Appendix Orifice Open
Schwannomas are rare mesenchymal tumors. They are usually diagnosed incidentally during endoscopic or diagnostic imaging for another reason. Malignant transformation is rare. In this case report, we present an incidental schwannoma protrud…
View article: AB158. SOH21AS134. Cardiac impact of trastuzumab in HER2 positive breast cancer
AB158. SOH21AS134. Cardiac impact of trastuzumab in HER2 positive breast cancer Open
Background: Human epidermal growth factors receptor-2 (HER2) positive breast cancer accounts for 10–25% of new diagnoses and adjuvant treatment with anti-HER2 agents such as Trastuzumab is standard of care. The cardiotoxic profile of these…
View article: Multidisciplinary approach to chest wall reconstruction in primary breast angiosarcoma resection
Multidisciplinary approach to chest wall reconstruction in primary breast angiosarcoma resection Open
Angiosarcomas account for less than 1% of primary breast cancers. Typically, they occur in young women with a low-risk personal or family history. Diagnosis, resection and reconstruction require a multidisciplinary team of breast surgeons,…
View article: AB076. Oncotype DX™: a necessary expense in the era of personalised medicine?
AB076. Oncotype DX™: a necessary expense in the era of personalised medicine? Open
Background: Oncotype DX™ (ODX) individualises patient adjuvant therapy whilst estimating prognosis. ODX relies on genetic signatures; the histopathological phenotype of which are tested routinely. We aimed to correlate ODX scores with clin…
View article: AB187. 144. Surgical ‘Kaizen’ 60-day review—what impact have we made?
AB187. 144. Surgical ‘Kaizen’ 60-day review—what impact have we made? Open
Background: In July this year, as part of the ‘Kaizen’, the UCHG surgical department undertook changes in order to increase efficiency relating to Emergency Surgery. ‘Kaizen’ is a Japanese term that literally means ‘change for better’. Fou…
View article: Effects of Age on the Detection and Management of Breast Cancer
Effects of Age on the Detection and Management of Breast Cancer Open
Currently, breast cancer affects approximately 12% of women worldwide. While the incidence of breast cancer rises with age, a younger age at diagnosis is linked to increased mortality. We discuss age related factors affecting breast cancer…
View article: Hospital tests and patient related factors influencing time-to-theatre in 1000 cases of suspected appendicitis: a cohort study
Hospital tests and patient related factors influencing time-to-theatre in 1000 cases of suspected appendicitis: a cohort study Open
This study highlights key hospital factors that influence TTT in patients with suspected appendicitis. Identification of these influential factors adds greatly to our understanding of patient prioritisation. Finally, TTT delays greater tha…
View article: Metastatic ovarian carcinoma presenting as an incarcerated femoral hernia
Metastatic ovarian carcinoma presenting as an incarcerated femoral hernia Open
In cases, where there is a known intra-abdominal malignancy & the presence of an incarcerated hernia, there should be a high index of suspicion for the presence of tumour within the hernial contents.