Ray Silva de Almeida
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View article: Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps Open
Background/Objectives: The increasing prevalence of multidrug-resistant Staphylococcus aureus represents a major clinical challenge, primarily driven by the acquisition of multiple resistance mechanisms. Among these, efflux pumps such as N…
View article: Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis
Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis Open
The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of conventional treatments. In this context, thiadiazines have emerged as promising agents due to their…
View article: Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps Open
The emergence of efflux-mediated resistance in Staphylococcus aureus has limited the effectiveness of conventional antibiotics, highlighting the need for novel adjuvant compounds. This study investigated the synthetic chalcone CMA4DMA as a…
View article: Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain Open
Background: Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already…
View article: Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the <em>Staphylococcus aureus </em>1199B Strain
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the <em>Staphylococcus aureus </em>1199B Strain Open
Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already known for t…
View article: Liposomal formulation with thiazolic compounds against bacterial efflux pumps
Liposomal formulation with thiazolic compounds against bacterial efflux pumps Open
This study aimed to evaluate the effects of liposome-encapsulated eugenol-based thiazolic derivatives against efflux pump-carrying bacteria. The Minimum Inhibitory Concentration (MIC) was determined to evaluate the antibacterial activity a…
View article: Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration Open
Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms developed by this species. The present study evaluates the inhibition of the MepA eff…
View article: Efeitos da Estimulação Sensório-Motora pelo Método Padovan® no Ganho de Peso de Prematuros com Peso Inferior a 1.500g
Efeitos da Estimulação Sensório-Motora pelo Método Padovan® no Ganho de Peso de Prematuros com Peso Inferior a 1.500g Open
Avaliar a eficácia do Método Padovan® na promoção do ganho de peso em recém-nascidos prematuros com muito baixo peso. Estudo observacional analítico retrospectivo realizado em um hospital e maternidade na região do Cariri entre 2020 e 2023…
View article: Impact of an antimicrobial stewardship program in a medium-sized hospital
Impact of an antimicrobial stewardship program in a medium-sized hospital Open
Problem considered: The rational use of antimicrobials (ATMs) is a challenge for global health services. One strategy used to control the spread of multidrug-resistant (MDR) bacteria is antimicrobial management programs. This is a pre- and…
View article: Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in Candida spp.
Enhancing the Antifungal Efficacy of Fluconazole with a Diterpene: Abietic Acid as a Promising Adjuvant to Combat Antifungal Resistance in Candida spp. Open
The increasing antifungal resistance rates against conventional drugs reveal the urgent need to search for new therapeutic alternatives. In this context, natural bioactive compounds have a critical role in antifungal drug development. Sinc…
View article: PREVALÊNCIA DE MICRORGANISMOS IDENTIFICADOS EM ESFREGAÇÕS CERVICO-VAGINAIS DE PACIENTES ATENDIDAS EM UMA UNIDADE BÁSICA DE SAÚDE DO MUNICÍPIO DE JUAZEIRO DO NORTE, CEARÁ
PREVALÊNCIA DE MICRORGANISMOS IDENTIFICADOS EM ESFREGAÇÕS CERVICO-VAGINAIS DE PACIENTES ATENDIDAS EM UMA UNIDADE BÁSICA DE SAÚDE DO MUNICÍPIO DE JUAZEIRO DO NORTE, CEARÁ Open
O objetivo deste estudo foi avaliar a prevalência de microrganismos identificados em exames de citologia oncótica de mulheres em uma comunidade de Juazeiro do Norte, CE. A pesquisa utilizou laudos do período de janeiro de 2013 a julho de 2…
View article: IMPACTOS DA PANDEMIA DE COVID 19 NA REALIZAÇÃO E RASTREIO DO CÂNCER DO COLO DO ÚTERO NO BRASIL
IMPACTOS DA PANDEMIA DE COVID 19 NA REALIZAÇÃO E RASTREIO DO CÂNCER DO COLO DO ÚTERO NO BRASIL Open
O objetivo desse trabalho foi avaliar através de levantamento de dados como a pandemia da COVID-19, prejudicou e dificultou a realização do exame de prevenção ao câncer de colo de útero. Trata-se de um trabalho de levantamento de dados, qu…
View article: AVALIAÇÃO DA PREVALÊNCIA DE CANDIDÍASE VAGINAL EM DIFERENTES FAIXAS ETÁRIAS
AVALIAÇÃO DA PREVALÊNCIA DE CANDIDÍASE VAGINAL EM DIFERENTES FAIXAS ETÁRIAS Open
O trabalho tem como objetivo, avaliar a prevalência de candidíase vaginal em diferentes faixas etárias através de uma revisão integrativa. Trata-se de uma revisão integrativa da literatura onde foram identificados tema, seleção da questão …
View article: INCIDÊNCIA DE CANDIDÍASE EM CITOLOGIAS REALIZADAS EM UM LABORATÓRIO DE ANÁLISES CLÍNICAS DA CIDADE DE JUAZEIRO DO NORTE- CEARÁ
INCIDÊNCIA DE CANDIDÍASE EM CITOLOGIAS REALIZADAS EM UM LABORATÓRIO DE ANÁLISES CLÍNICAS DA CIDADE DE JUAZEIRO DO NORTE- CEARÁ Open
Objetiva-se analisar a incidência de candidíase em citologias realizadas em um laboratório de análises clínicas da cidade de Juazeiro do Norte-CE. Foram analisados os registros dos exames preventivos realizados pelas mulheres do referido l…
View article: Chondrodendron platyphyllum alkaloids as a weapon in the combat of antibiotic resistance
Chondrodendron platyphyllum alkaloids as a weapon in the combat of antibiotic resistance Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: Toxicity Analysis of Some Frequently Used Food Processing Chemicals Using Allium cepa Biomonitoring System
Toxicity Analysis of Some Frequently Used Food Processing Chemicals Using Allium cepa Biomonitoring System Open
Frequent use of various food processing chemical agents sometimes causes damage to our bodies by inducing cytotoxicity, genotoxicity, and mutagenesis. In Bangladesh, among various chemical agents, formalin, saccharin, and urea are vastly u…
View article: Scientific evidences of anticancer potential of medicinal plants
Scientific evidences of anticancer potential of medicinal plants Open
Cancer being a life treating ailment is the second reason of death universally. The growing threats of medication-resistant cancers indicates an crucial need for the improvement of more effective anticancer agents. Herbal medication offers…
View article: Chemical characterization and in vitro anticancer effect of Asplenium aethiopicum (Burm. f.) Becherer
Chemical characterization and in vitro anticancer effect of Asplenium aethiopicum (Burm. f.) Becherer Open
Ferns and fern allies, well know for their ornamental value, also have medicinal properties. Previous studies on Asplenium aethiopicum (Burm. f.) Becherer determined its antioxidant, larvicidal and cytotoxic potential using brine shrimp bi…
View article: Ethnobotanical uses and phytochemical, biological, and toxicological profiles of Datura metel L.: A review
Ethnobotanical uses and phytochemical, biological, and toxicological profiles of Datura metel L.: A review Open
View article: Terpenes as bacterial efflux pump inhibitors: A systematic review
Terpenes as bacterial efflux pump inhibitors: A systematic review Open
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development h…
View article: Potentiation of Antibiotic Action and Efflux Pump Inhibitory Effect on Staphylococcus aureus Strains by Solasodine
Potentiation of Antibiotic Action and Efflux Pump Inhibitory Effect on Staphylococcus aureus Strains by Solasodine Open
A worrisome fact is the increase in microbial resistance, which has as its main cause the indiscriminate use of antibiotics. Scientific studies have investigated bioactive compounds such as steroidal sapogenins, in the perspective of new b…
View article: Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review
Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review Open
Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat canc…
View article: Green synthesis of nano-liposomes containing Bunium persicum and Trachyspermum ammi essential oils against Trichomonas vaginalis
Green synthesis of nano-liposomes containing Bunium persicum and Trachyspermum ammi essential oils against Trichomonas vaginalis Open
These data suggested that nano-liposomes of the essential oils of B. persicum and T. ammi may be a promising alternative to current treatments for Trichomonas infection.
View article: Lectins ConA and ConM extracted from Canavalia ensiformis (L.) DC and Canavalia rosea (Sw.) DC inhibit planktonic Candida albicans and Candida tropicalis
Lectins ConA and ConM extracted from Canavalia ensiformis (L.) DC and Canavalia rosea (Sw.) DC inhibit planktonic Candida albicans and Candida tropicalis Open
View article: Nanoencapsulation of buriti oil (Mauritia flexuosa L.f.) in porcine gelatin enhances the antioxidant potential and improves the effect on the antibiotic activity modulation
Nanoencapsulation of buriti oil (Mauritia flexuosa L.f.) in porcine gelatin enhances the antioxidant potential and improves the effect on the antibiotic activity modulation Open
The present study evaluated the cytotoxicity, antioxidant potential, and antimicrobial effect on the antibiotic activity modulation of gelatin nanoparticles containing buriti oil (OPG). The cytotoxicity analysis was performed on Chinese Ha…
View article: In vitro Antioxidant Potential of Abrus precatorius L. and Asystasia gangetica (L.) T. Anderson
In vitro Antioxidant Potential of Abrus precatorius L. and Asystasia gangetica (L.) T. Anderson Open
Antioxidant substances are an important part of human life as it plays a key role in nutraceuticals and also help to defend free radicals present in our body. The present study highlights the need to find potent natural antioxidants from m…
View article: Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association
Enhancement of the antibiotic activity mediated by the essential oil of Ocotea odorifera (VELL) ROWHER and safrole association Open
aLaboratório de Microbiologia e Biologia Molecular — LMBM, Universidade Regional do Cariri, Crato, CE, BrazilbGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), BrazilcCentro Universitário Christus — Unichristus, Fortaleza,…
View article: Biochemical Profile, In vitro Toxicity, and Cytotoxic activity of Eragrostis amabilis (L.) Wight. Arn. and Eragrostis pilosa (L.) Beauve
Biochemical Profile, In vitro Toxicity, and Cytotoxic activity of Eragrostis amabilis (L.) Wight. Arn. and Eragrostis pilosa (L.) Beauve Open
The present study is intended to reveal the biochemical profile and assess the toxicity and cytotoxic activity of aerial and underground parts of Eragrostis amabilis (L.) Wight. Arn. and Eragrostis pilosa (L.) Beauv. extracts using Brine s…
View article: Phytochemical characterization and antibiotic potentiating effects of the essential oil of Aloysia gratissima (Gillies & Hook.) and beta-caryophyllene
Phytochemical characterization and antibiotic potentiating effects of the essential oil of Aloysia gratissima (Gillies & Hook.) and beta-caryophyllene Open
a Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, Brazil
\nb Gon¸calo Moniz Institute (IGM), Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BA, Brazil
\nc Maurício de Nassau College -UNINASSAU, Petrolina, PE,…
View article: Enhanced antibacterial effect of antibiotics by the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. and its major constituent beta-caryophyllene
Enhanced antibacterial effect of antibiotics by the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. and its major constituent beta-caryophyllene Open
a Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, Brazil b Maurício de Nassau College -UNINASSAU, Petrolina, PE, Brazil c Post graduate Program in Sustainable Territorial Development, Federal University of …