Ray Vanderby
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View article: Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation
Transcriptomic landscape around wound bed defines regenerative versus non-regenerative outcomes in mouse digit amputation Open
In the mouse distal terminal phalanx (P3), it remains mystery why amputation at less than 33% of the digit results in regeneration, while amputation exceeding 67% leads to non-regeneration. Unraveling the molecular mechanisms underlying th…
View article: Transcriptomic Landscape and Immune Microenvironment Around Wound Bed Define Regenerative versus Non-regenerative Outcomes in Mouse Digit Amputation
Transcriptomic Landscape and Immune Microenvironment Around Wound Bed Define Regenerative versus Non-regenerative Outcomes in Mouse Digit Amputation Open
In the mouse distal terminal phalanx (P3), it remains unclear why amputation at less than 33% of the digit results in regeneration, while amputation exceeding 67% leads to non-regeneration. Unraveling the molecular mechanisms underlying th…
View article: Interleukin-6 and Interleukin-8 Gene Expressions Differ Between Male and Female Patients at Time of Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Interleukin-6 and Interleukin-8 Gene Expressions Differ Between Male and Female Patients at Time of Hip Arthroscopy for Femoroacetabular Impingement Syndrome Open
View article: Modulating the mesenchymal stromal cell microenvironment alters exosome RNA content and ligament healing capacity
Modulating the mesenchymal stromal cell microenvironment alters exosome RNA content and ligament healing capacity Open
Although mesenchymal stromal cell (MSC) based therapies hold promise in regenerative medicine, their clinical application remains challenging due to issues such as immunocompatibility. MSC-derived exosomes are a promising off-the-shelf the…
View article: Modulating Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity
Modulating Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity Open
Although mesenchymal stromal cell (MSC) based therapies hold promise in regenerative medicine, their applications in clinical settings remain challenging due to issues such as immunocompatibility and cell stability. MSC-derived exosomes, s…
View article: Periostin modulates extracellular matrix behavior in tendons
Periostin modulates extracellular matrix behavior in tendons Open
View article: Beyond the Core Suture: A New Approach to Tendon Repair
Beyond the Core Suture: A New Approach to Tendon Repair Open
Background: Despite significant improvements in zone II flexor tendon repair over the last 2 decades, function-limiting complications persist. This article describes 2 novel repair techniques utilizing flexor digitorum superficialis (FDS) …
View article: Exosome-educated macrophages and exosomes differentially improve ligament healing
Exosome-educated macrophages and exosomes differentially improve ligament healing Open
Recently, our group used exosomes from mesenchymal stromal/stem cells (MSCs) to simulate an M2 macrophage phenotype, that is, exosome-educated macrophages (EEMs). These EEMs, when delivered in vivo, accelerated healing in a mouse Achilles …
View article: TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes
TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes Open
Comparative time series transcriptome analysis is a powerful tool to study development, evolution, aging, disease progression and cancer prognosis. We develop TimeMeter, a statistical method and tool to assess temporal gene expression simi…
View article: Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing
Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing Open
Tendon healing follows a complex series of coordinated events, which ultimately produces a mechanically inferior tissue more scar-like than native tendon. More regenerative healing occurs when anti-inflammatory M2 macrophages play a more d…
View article: Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament
Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament Open
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and c…
View article: Mesenchymal Stem Cell Therapy on Tendon/Ligament Healing
Mesenchymal Stem Cell Therapy on Tendon/Ligament Healing Open
A normal healing response after ligament and tendon rupture results in scar formation and an inferior tissue that fails to emulate its original structure, composition, and function. More regenerative healing (closer to the original) can be…
View article: Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study
Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study Open
Stem cells have shown promise as a therapeutic intervention by enhancing skeletal muscle regeneration following muscle injury. The purpose of this study was to determine the effect of mouse mesenchymal stem cells (MSCs) on muscle function …
View article: Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect
Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect Open
Tendon healing is a complex coordinated series of events resulting in protracted recovery, limited regeneration, and scar formation. Mesenchymal stem cell (MSC) therapy has shown promise as a new technology to enhance soft tissue and bone …
View article: 3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties
3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties Open
View article: Primed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing
Primed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing Open
View article: Crown Preservation of the Mandibular First Molar Tooth Impacts the Strength and Stiffness of Three Non-Invasive Jaw Fracture Repair Constructs in Dogs
Crown Preservation of the Mandibular First Molar Tooth Impacts the Strength and Stiffness of Three Non-Invasive Jaw Fracture Repair Constructs in Dogs Open
Repairing mandibular body fractures presents unique challenges not encountered when repairing long bones. Large tooth roots and the presence of the inferior alveolar neurovascular bundle limit safe placement for many types of orthopedic im…
View article: Shear loads induce cellular damage in tendon fascicles
Shear loads induce cellular damage in tendon fascicles Open
View article: Articular cartilage zonal differentiation via 3D Second-Harmonic Generation imaging microscopy
Articular cartilage zonal differentiation via 3D Second-Harmonic Generation imaging microscopy Open
Collectively, these results provide quantitative measurements of structural changes at both the fiber and fibril assembly of the different cartilage zones and reveals structural information not possible by other microscope modalities. This…
View article: Shear load transfer in high and low stress tendons
Shear load transfer in high and low stress tendons Open