Ray E. Bowman
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View article: HIRA protects telomeres against R-loop-induced instability in ALT cancer cells
HIRA protects telomeres against R-loop-induced instability in ALT cancer cells Open
Inactivating mutations in chromatin modifiers, like the α-thalassemia/mental retardation, X-linked (ATRX)-death domain-associated protein (DAXX) chromatin remodeling/histone H3.3 deposition complex, drive the cancer-specific alternative le…
View article: TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling Open
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified…