Raymond E. Samuel
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View article: Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology
Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology Open
Introduction Human metabolically competent HepaRG™ (HepaRG) cells have been developed as a human-relevant New Approach Methodology (NAM) in genetic toxicology, providing a non-animal alternative to rodent-based mutagenicity testing followi…
View article: Fifteen day repeat air: liquid Interface air-only exposures can cause respiratory epithelium injury in MucilAir <sup>™</sup> nasal respiratory epithelial cells that parallels chemically induced cytotoxicity
Fifteen day repeat air: liquid Interface air-only exposures can cause respiratory epithelium injury in MucilAir <sup>™</sup> nasal respiratory epithelial cells that parallels chemically induced cytotoxicity Open
New Approach Methodologies (NAMs) are being widely used to reduce, refine, and replace, animal use in studying toxicology. For respiratory toxicology, this includes in silico and in vitro alternatives using air:liquid interface (ALI) expos…
View article: Integrating gene expression and splicing dynamics across dose-response oxidative modulators
Integrating gene expression and splicing dynamics across dose-response oxidative modulators Open
Toxicological risk assessment increasingly utilizes transcriptomics to derive point of departure (POD) and modes of action (MOA) for chemicals. One essential biological process that allows a single gene to generate several different RNA is…
View article: Radioactive waste: A review
Radioactive waste: A review Open
The reviewed papers presented here provide a general overview of worldwide radioactive waste‐related studies conducted in 2019. The current review includes studies related to safety assessments, decommission and decontamination of nuclear …
View article: Textiles wastewater treatment technology: A review
Textiles wastewater treatment technology: A review Open
The following is a review of published literature on textile wastewater in 2019. Presented are the sections described for the review: concise introduction on the textiles wastewater, followed by a review of present textile treatment techno…