Raymond K. Walters
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View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorde…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistica…
View article: Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation Open
View article: The landscape of gene loss and missense variation across the mammalian tree informs on gene essentiality
The landscape of gene loss and missense variation across the mammalian tree informs on gene essentiality Open
Background The degree of gene and sequence preservation across species provides valuable insights into the relative necessity of genes from the perspective of natural selection. Here, we developed novel interspecies metrics across 462 mamm…
View article: Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects
Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects Open
Summary Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits. However, individuals from diverse genetic ancestry groups are often excluded…
View article: Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes
Distinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes Open
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting more than 16 million pregnancies annually worldwide 1,2 . GDM is related to an increased lifetime risk of type 2 diabetes (T2D) 1–3 , with over a third of women d…
View article: Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci
Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci Open
View article: Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open
View article: Distinct and shared genetic architectures of Gestational diabetes mellitus and Type 2 Diabetes Mellitus
Distinct and shared genetic architectures of Gestational diabetes mellitus and Type 2 Diabetes Mellitus Open
Gestational diabetes mellitus (GDM) affects more than 16 million pregnancies annually worldwide and is related to an increased lifetime risk of Type 2 diabetes (T2D). The diseases are hypothesized to share a genetic predisposition, but the…
View article: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open
View article: Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups Open
View article: Evaluation of a Two-Stage Statistical Learning Design for Genome-Wide Studies
Evaluation of a Two-Stage Statistical Learning Design for Genome-Wide Studies Open
Twin and family studies show that many common traits and disorders are highly heritable, but genome-wide association studies (GWAS) have been largely unable to identify specific single nucleotide polymorphisms (SNPs) explaining this herita…
View article: Estimating Variance Explained by all DNA Loci in a Genome-Wide Meta-Analysis
Estimating Variance Explained by all DNA Loci in a Genome-Wide Meta-Analysis Open
Twin and family studies have routinely observed that many psychological traits and disorders are at least moderately heritable (Turkheimer & Gottesman, 1991). Genome-wide studies of single nucleotide polymorphisms (SNPs), however, have had…
View article: Principled distillation of multidimensional UK Biobank data reveals insights into the correlated human phenome
Principled distillation of multidimensional UK Biobank data reveals insights into the correlated human phenome Open
Broad yet detailed data collected in biobanks captures variation reflective of human health and behavior, but insights are hard to extract given their complexity and scale. In the largest factor analysis to date, we distill hundreds of med…
View article: The female protective effect against autism spectrum disorder
The female protective effect against autism spectrum disorder Open
Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited g…
View article: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open
Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder, with a major genetic component. Here we present a GWAS meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We id…
View article: Patterns of item nonresponse behavior to survey questionnaires are systematic and have a genetic basis
Patterns of item nonresponse behavior to survey questionnaires are systematic and have a genetic basis Open
Response to survey questionnaires is vital for social and behavioral research, and most analyses assume full and accurate response by survey participants. However, nonresponse is common and impedes proper interpretation and generalizabilit…
View article: The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates Open
View article: Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans Open
View article: Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder Open
Background Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders. Methods We used the largest…
View article: Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups
Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups Open
Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental disorders with a considerable overlap in their genetic etiology. We dissected their shared and distinct genetic arch…
View article: Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations
Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations Open
We present a new method, Multi-Ancestry Meta-Analysis (MAMA), which combines genome-wide association study (GWAS) summary statistics from multiple populations to produce new summary statistics for each population, identifying novel loci th…
View article: Genetic analyses identify widespread sex-differential participation bias
Genetic analyses identify widespread sex-differential participation bias Open
View article: The female protective effect against autism spectrum disorder
The female protective effect against autism spectrum disorder Open
Autism spectrum disorder (ASD) is diagnosed 3-4 times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common, inherited genetic ri…
View article: Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder Open
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21566-w
View article: Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans Open
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03174-8.
View article: The Addiction Risk Factor: A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates
The Addiction Risk Factor: A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates Open
Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested whether a common genetic facto…
View article: Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls Open
Background Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent a…
View article: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder Open
View article: Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits Open
Sex differences in the common autosomal genetic architecture of neuropsychiatric and behavioral phenotypes are small and polygenic and unlikely to fully account for observed sex-differentiated attributes. Larger sample sizes are needed to …