Raymond Laboy
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View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohy…
View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohyd…
View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohyd…
View article: Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity Open
Late-life-initiated dietary interventions show limited efficacy in extending longevity or mitigating frailty, yet the underlying causes remain unclear. Here we studied the age-related fasting response of the short-lived killifish Nothobran…
View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohy…
View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohyd…
View article: Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics
Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics Open
The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans . These transcription factors coordinate nutrient sensing with carbohy…
View article: Mitochondrial translocation of TFEB regulates complex I and inflammation
Mitochondrial translocation of TFEB regulates complex I and inflammation Open
TFEB is a master regulator of autophagy, lysosome biogenesis and mitochondrial metabolism that works, and immunity, primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulator…
View article: A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature
A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature Open
Objective We describe a family with a novel mutation in the TNF Receptor Superfamily Member 1A (TNFRSF1A) gene causing TNF receptor–associated periodic syndrome (TRAPS) with renal AA amyloidosis. Methods Case series of affected family memb…
View article: miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging
miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging Open
Muscle function relies on the precise architecture of dynamic contractile elements, which must be fine-tuned to maintain motility throughout life. Muscle is also plastic, and remodeled in response to stress, growth, neural and metabolic in…
View article: miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing
miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing Open
Muscle function relies on the precise architecture of dynamic contractile elements, which must be fine-tuned to maintain motility throughout life. Muscle is also highly plastic, and remodelled in response to stress, growth, neural and meta…
View article: Slm35 links mitochondrial stress response and longevity through TOR signaling pathway
Slm35 links mitochondrial stress response and longevity through TOR signaling pathway Open
In most eukaryotic cells mitochondria are essential organelles involved in a great variety of cellular functions. One of the physiological processes linked to mitochondria is aging, a gradual process of damage accumulation that eventually …