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View article: Repeated head trauma causes neuron loss and inflammation in young athletes
Repeated head trauma causes neuron loss and inflammation in young athletes Open
View article: Cerebrovascular remodeling in aging and neurodegenerative disease progression
Cerebrovascular remodeling in aging and neurodegenerative disease progression Open
The cerebrovasculature is responsible for supplying oxygenated blood and nutrients to the brain and removing neurotoxic buildup. With age, trauma, and disease, the structural constituents of cerebral arteries including the extracellular ma…
View article: Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains
Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains Open
Stathmin-2 (STMN2) levels decline in brains with transactive response DNA binding protein-43 (TDP-43) inclusions. TDP-43-related changes could extend to ocular structures, although vitreous STMN2 levels remain uncharacterized. This explora…
View article: Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts
Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts Open
View article: Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy
Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy Open
Importance Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHIs). Prior research suggests a dose-response association between American football play duration and CTE risk and…
View article: SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue
SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue Open
Postmortem human brain tissue is a critical resource for studying neurodegenerative disease, providing critical insights into cellular morphology, pathology, and network connectivity. To improve standard microscopy and enable high-resoluti…
View article: Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes
Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes Open
Repetitive head impacts (RHI) sustained from contact sports are the largest risk factor for chronic traumatic encephalopathy (CTE). Currently, CTE can only be diagnosed after death and the multicellular cascade of events that trigger initi…
View article: Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE
Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE Open
View article: Relative Contributions of Mixed Pathologies to Cognitive and Functional Symptoms in Brain Donors Exposed to Repetitive Head Impacts
Relative Contributions of Mixed Pathologies to Cognitive and Functional Symptoms in Brain Donors Exposed to Repetitive Head Impacts Open
Objective Exposure to repetitive head impacts (RHI) is associated with later‐life cognitive symptoms and neuropathologies, including chronic traumatic encephalopathy (CTE). Cognitive decline in community cohorts is often due to multiple pa…
View article: Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts
Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts Open
Importance Young contact sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic encephalopathy (CTE). Objective To characterize the neuropathologic and clinical symptoms of young brain donors who…
View article: Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy Open
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by perivascular accumulations of hyperphosphorylated tau protein (p-tau) at the depths of the…
View article: Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer’s Disease and Chronic Traumatic Encephalopathy
Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer’s Disease and Chronic Traumatic Encephalopathy Open
Background: Patients with eye disease have an increased risk for developing neurodegenerative disease. Neurodegenerative proteins can be measured in the eye; however, correlations between biomarker levels in eye fluid and neuropathological…
View article: Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis Open
View article: MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis
MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis Open
Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis (ALS). ALS and CTE are distinct disorders, yet in some …
View article: A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease
A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease Open
View article: Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease
Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease Open
Introduction Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI) typically sustained by contact sport athletes. Post‐translation modifications to tau in CTE have not been we…
View article: A Comparison Between Tau and Amyloid-β Cerebrospinal Fluid Biomarkers in Chronic Traumatic Encephalopathy and Alzheimer Disease
A Comparison Between Tau and Amyloid-β Cerebrospinal Fluid Biomarkers in Chronic Traumatic Encephalopathy and Alzheimer Disease Open
Background Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer’s disease (AD), are largely unknown. We examined postmortem CSF …
View article: Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology
Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology Open
Introduction Validity of the 2014 traumatic encephalopathy syndrome (TES) criteria, proposed to diagnose chronic traumatic encephalopathy (CTE) in life, has not been assessed. Methods A total of 336 consecutive brain donors exposed to repe…
View article: CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy
CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy Open
View article: Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy
Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy Open
View article: Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy
Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy Open
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy characterized by accumulation of hyperphosphorylated tau (p‐tau) in perivascular aggregates in neurons and glia at the depths of neocortical sulci and progresses to di…
View article: Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype
Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype Open
Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε 4 allele is the most common genetic risk factor for AD…
View article: Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy
Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy Open
View article: Variation in TMEM106B in chronic traumatic encephalopathy
Variation in TMEM106B in chronic traumatic encephalopathy Open
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative…
View article: Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports Open
Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CT…