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View article: Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential
Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential Open
Yersinia pestis , the causative agent of plague and a biological threat agent, presents an urgent need for novel medical countermeasures due to documented cases of naturally acquired antibiotic resistance and potential person-to-person spr…
View article: Evaluation of two different vaccine platforms for immunization against melioidosis and glanders
Evaluation of two different vaccine platforms for immunization against melioidosis and glanders Open
Burkholderia pseudomallei and the closely related species, Burkholderia mallei , produce similar multifaceted diseases which range from rapidly fatal to protracted and chronic, and are a major cause of mortality in endemic regions. Besides…
View article: Plague Prevention and Therapy: Perspectives on Current and Future Strategies
Plague Prevention and Therapy: Perspectives on Current and Future Strategies Open
Plague, caused by the bacterial pathogen Yersinia pestis, is a vector-borne disease that has caused millions of human deaths over several centuries. Presently, human plague infections continue throughout the world. Transmission from one ho…
View article: Impact of Toll-Like Receptor-Specific Agonists on the Host Immune Response to the Yersinia pestis Plague rF1V Vaccine
Impact of Toll-Like Receptor-Specific Agonists on the Host Immune Response to the Yersinia pestis Plague rF1V Vaccine Open
Relatively recent advances in plague vaccinology have produced the recombinant fusion protein F1-V plague vaccine. This vaccine has been shown to readily protect mice from both bubonic and pneumonic plague. The protection afforded by this …
View article: Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women
Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women Open
The U.S. Hispanic female population has one of the highest breast cancer (BC) incidence and mortality rates, while BC is the leading cause of cancer death in Puerto Rican women. Certain foods may predispose to carcinogenesis. Our previous …
View article: Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis
Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis Open
Burkholderia mallei , the causative agent of glanders, is a gram-negative intracellular bacterium. Depending on different routes of infection, the disease is manifested by pneumonia, septicemia, and chronic infections of the skin. B. malle…
View article: Protection Elicited by Attenuated Live Yersinia pestis Vaccine Strains against Lethal Infection with Virulent Y. pestis
Protection Elicited by Attenuated Live Yersinia pestis Vaccine Strains against Lethal Infection with Virulent Y. pestis Open
The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which poses both a natural and adversarial threat. Due largely to the rapid course and high mortality of pneumonic plague, vaccines are greatly needed. Two-…
View article: The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice
The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice Open
The administration of antipyretic analgesics prior to, in conjunction with, or due to sequelae associated with vaccination is a common yet somewhat controversial practice. In the context of human vaccination, it is unclear if even short-te…
View article: Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer
Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer Open
For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effect…
View article: Reishi reduces PI3K/AKT/mTOR and MAPK pathway gene and protein expression.
Reishi reduces PI3K/AKT/mTOR and MAPK pathway gene and protein expression. Open
A. RT2 PCR array designed to profile the expression of PI3K/AKT pathway-specific genes was performed using 500 ng of tumor extracted RNA, according to manufacturer’s instructions (SA Biosciences). Volcano plot show effects on ge…