Rayyan Gorashi
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View article: Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification
Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification Open
Sex differences in aortic valve stenosis (AVS) progression have been documented clinically, but the underlying cellular mechanisms that drive sex-dependent calcification in aortic valve tissue remain poorly understood. Here, we harnessed s…
View article: Y chromosome–linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues
Y chromosome–linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues Open
Aortic valve stenosis (AVS) is a progressive disease, wherein males more often develop valve calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) aberrantly activate to myofibroblasts during AVS…
View article: Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues
Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues Open
Aortic valve stenosis (AVS) is a progressive disease wherein males more often develop valve calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) aberrantly activate to myofibroblasts during AVS,…
View article: Modeling diabetic endothelial dysfunction with patient‐specific induced pluripotent stem cells
Modeling diabetic endothelial dysfunction with patient‐specific induced pluripotent stem cells Open
Diabetes is a known risk factor for various cardiovascular complications, mediated by endothelial dysfunction. Despite the high prevalence of this metabolic disorder, there is a lack of in vitro models that recapitulate the complexity of g…
View article: Chemical and molecular tools to probe biological sex differences at multiple length scales
Chemical and molecular tools to probe biological sex differences at multiple length scales Open
Sex differences in biology are observed at multiple different length scales and across organ systems.