Razan Sheta
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View article: Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson’s disease
Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson’s disease Open
Presynaptic accumulation of misfolded α-synuclein (α-syn) and altered synaptic transmission are considered early events in the pathogenesis of Parkinson's disease (PD), suggesting a potential causal link between these two events. However, …
View article: Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis
Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis Open
Lipid droplets (LDs), once considered inert lipid stores, are now recognized as active regulators of lipid metabolism, stress responses, and protein quality control in the brain. Their dysregulation is increasingly linked to neurodegenerat…
View article: Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease
Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease Open
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the degeneration of dopamine neurons in the substantia nigra pars compacta, leading to motor and non-motor symptoms. While motor symptoms such as rigidity,…
View article: Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease
Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease Open
Studying Parkinson's disease (PD) is complex due to a lack of cellular models mimicking key aspects of protein pathology. Here, we present a protocol for inducing and monitoring α-synuclein aggregation in living cells using optogenetics. W…
View article: Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization
Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization Open
Accumulation of α-synuclein aggregates in the substantia nigra pars compacta is central in the pathophysiology of Parkinson’s disease, leading to the degeneration of dopaminergic neurons and the manifestation of motor symptoms. Although se…
View article: Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons
Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons Open
Generation of functional human dopaminergic (DA) neurons from human induced pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human diseases and cell replacement therapies. Here, we present a protocol to combi…
View article: A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease Open
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, the exact role of protein aggregation in the pathophysiology of these d…
View article: Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association Open
Abnormal accumulation of the protein α- synuclein (α-syn) into proteinaceous inclusions called Lewy bodies (LB) is the neuropathological hallmark of Parkinson’s disease (PD) and related disorders. Interestingly, a growing body of evidence …
View article: Additional file 6 of Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy
Additional file 6 of Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy Open
Additional file 6. Genes, differentially expressed between Sensitive (S) and resistant (R) AsPCs (≥ 1.5 fold, p ≤ 0.05). Table presenting the subset of differentially expressed genes that were selected by initial filtering on confidence at…
View article: The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression
The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression Open
Epithelial ovarian cancer (EOC) represents the most lethal gynecologic malignancy; a better understanding of the molecular mechanisms associated with EOC etiology could substantially improve EOC management. Aberrant O-glycosylation in canc…
View article: Elucidating the role of the family of GalNAc-Transferases in aberrant protein O-glycosylation in the progression of epithelial ovarian cancer
Elucidating the role of the family of GalNAc-Transferases in aberrant protein O-glycosylation in the progression of epithelial ovarian cancer Open
Le cancer épithélial de l’ovaire (CEO) est la forme de cancer gynécologique la plus létale. Ainsi, la compréhension des changements moléculaires associés à ce cancer métastatique ovarien peut mener à l’identification de nouvelles cibles th…
View article: Altered expression of different GalNAc-transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer
Altered expression of different GalNAc-transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer Open
Protein glycosylation perturbations are implicated in a variety of diseases, including cancer. Aberrant glycosylation in cancer is frequently attributed to altered expression of polypeptide GalNAc transferases (GalNAc‑Ts) - enzymes initiat…
View article: Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner
Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner Open
The molecular basis of epithelial ovarian cancer (EOC) dissemination is still poorly understood. We have previously identified the hydrogen peroxide-inducible clone-5 (Hic-5) gene as hypomethylated in high-grade (HG) serous EOC tumors, com…
View article: Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells Open
Previously, we have identified the Grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared with normal ovarian tissues. GRHL2 is known for its functions in norm…
View article: Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells Open
Previously, we have identified the Grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared with normal ovarian tissues. GRHL2 is known for its functions in norm…