Ruqaiyyah Siddiqui
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View article: Digital twin modelling in microgravity: A framework for predictive and personalised space medicine
Digital twin modelling in microgravity: A framework for predictive and personalised space medicine Open
View article: Gut microbiome-derived metabolites and epigenetic modulation as potential countermeasures to acute stress
Gut microbiome-derived metabolites and epigenetic modulation as potential countermeasures to acute stress Open
View article: The growing health hazards of microplastics in Pakistan’s environment
The growing health hazards of microplastics in Pakistan’s environment Open
Dear Editor, I am writing to highlight a critical yet overlooked public health crisis in Pakistan: the increasing prevalence of microplastics in our environment and the long-term health risks they pose. Microplastics are plastic particles …
View article: Epigenetics and gut microbiome of reptiles can reveal potential targets to improve human health and performance
Epigenetics and gut microbiome of reptiles can reveal potential targets to improve human health and performance Open
View article: Effective targeting of pathogenic Acanthamoeba castellanii of the T4 genotype using nano-formulations of Quercetin
Effective targeting of pathogenic Acanthamoeba castellanii of the T4 genotype using nano-formulations of Quercetin Open
The incidence of infections caused by pathogenic Acanthamoeba is increasing, yet the prognosis continues to be poor. Acanthamoeba spp. are responsible for causing a blinding keratitis and a fatal granulomatous...
View article: Exploring novel thiazole-based minor groove binding agents as potential therapeutic agents against pathogenic <i>Acanthamoeba castellanii</i>
Exploring novel thiazole-based minor groove binding agents as potential therapeutic agents against pathogenic <i>Acanthamoeba castellanii</i> Open
Acanthamoeba infections remain a medical challenge due to limited diagnosis, therapies, and unclear pathophysiology. DNA-targeting minor groove binders show promise as novel antiamoebic agents.
View article: Correction: Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients
Correction: Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients Open
[This corrects the article DOI: 10.1371/journal.pone.0283608.].
View article: Assessment of <i>in vitro</i> dynamics of pathogenic environmental <i>Acanthamoeba</i> T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer
Assessment of <i>in vitro</i> dynamics of pathogenic environmental <i>Acanthamoeba</i> T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer Open
Free-living amoebae of the genus Acanthamoeba are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better underst…
View article: An overview of breast cancer in Pakistan
An overview of breast cancer in Pakistan Open
View article: Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being
Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being Open
View article: Emerging therapies against <i>Naegleria fowleri</i>
Emerging therapies against <i>Naegleria fowleri</i> Open
Introduction Naegleria fowleri is a free-living protist pathogen. Given the opportunity, it can produce infection of the central nervous system. It is distressing that the brain-eating amoebae, Naegleria fowleri remains one of the lethal p…
View article: Sappinia spp.: An update
Sappinia spp.: An update Open
Sappinia is a free-living amoeba isolated from soil, dead plant material, freshwater, ponds, water supplies, surface water and the faecal material of various organisms such as cows, bats, reptiles, King penguin, and even humans. Of note, S…
View article: Nanoparticle-Terpene Fusion: A Game-Changer in Combating Primary Amoebic Meningoencephalitis Caused by <i>Naegleria fowleri</i>
Nanoparticle-Terpene Fusion: A Game-Changer in Combating Primary Amoebic Meningoencephalitis Caused by <i>Naegleria fowleri</i> Open
Pathogenic Naegleria fowleri (N. fowleri) are opportunistic free-living amoebae and are the causative agents of a very rare but severe brain infection called primary amoebic meningoencephalitis (PAM). The fatality rate of PAM…
View article: Serum multi-omics analysis in hindlimb unloading mice model: Insights into systemic molecular changes and potential diagnostic and therapeutic biomarkers
Serum multi-omics analysis in hindlimb unloading mice model: Insights into systemic molecular changes and potential diagnostic and therapeutic biomarkers Open
View article: Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii
Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii Open
A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba. Currently, no therapeutic age…
View article: Unveiling the molecular Culprit of arterial stiffness in vitamin D deficiency and obesity: Potential for novel therapeutic targets
Unveiling the molecular Culprit of arterial stiffness in vitamin D deficiency and obesity: Potential for novel therapeutic targets Open
Cardiovascular diseases (CVDs) are highly associated with both vitamin D deficiency and obesity, two prevalent health conditions worldwide. Arterial stiffness, an independent predictor of CVDs, is particularly elevated in both conditions, …
View article: Is the gut microbiome of insects a potential source to meet <scp>UN</scp> sustainable development goals to eliminate plastic pollution?
Is the gut microbiome of insects a potential source to meet <span>UN</span> sustainable development goals to eliminate plastic pollution? Open
As insects such as cockroaches can endure high radiation, flourish in unsanitary circumstances, thrive on germ‐infested feed, and can even digest the organic polymer cellulose, the gut microbiota of these species likely produces enzymes co…
View article: Molecular characterisation and potential pathogenicity analysis of <i>Acanthamoeba</i> isolated from recreational lakes in Peninsular Malaysia
Molecular characterisation and potential pathogenicity analysis of <i>Acanthamoeba</i> isolated from recreational lakes in Peninsular Malaysia Open
The present study aims to identify the Acanthamoeba genotypes and their pathogenic potential in three recreational lakes in Malaysia. Thirty water samples were collected by purposive sampling between June and July 2022. Physical parameters…
View article: Can Amphotericin B-mediated Effects Be Limited Using Intranasal Versus Intravenous route?
Can Amphotericin B-mediated Effects Be Limited Using Intranasal Versus Intravenous route? Open
Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of A…
View article: THE IMPACT OF CLIMATIC FACTORS AND FOOD SECURITY ON DEMOGRAPHIC FERTILITY IN PUNJAB, PAKISTAN THROUGH GEOSPATIAL STRUCTURAL MODELLING (GSSM)
THE IMPACT OF CLIMATIC FACTORS AND FOOD SECURITY ON DEMOGRAPHIC FERTILITY IN PUNJAB, PAKISTAN THROUGH GEOSPATIAL STRUCTURAL MODELLING (GSSM) Open
: Punjab is not only the most fertile province of Pakistan but also the most fertile demographically with 3.4 total fertility rate. The fertility rate is an important demographic phenomenon that has significant implications for sustainable…
View article: COVID-19: Acanthamoeba Creeps into the Brain
COVID-19: Acanthamoeba Creeps into the Brain Open
The Article Abstract is not available.
View article: Bacterial flora varies throughout the saltwater crocodile (Crocodylus porosus) gastrointestinal tract
Bacterial flora varies throughout the saltwater crocodile (Crocodylus porosus) gastrointestinal tract Open
OBJECTIVE The objective of this study was to determine bacterial flora throughout the gastrointestinal tract of a saltwater crocodile ( Crocodylus porosus ) using 16S rRNA gene analysis. ANIMALS A convention on international trade in endan…
View article: The Increasing Importance of the Oral Microbiome in Periodontal Health and Disease
The Increasing Importance of the Oral Microbiome in Periodontal Health and Disease Open
Herein, the aim is to discuss the current knowledge of microbiome and periodontal diseases. Current treatment strategies include mechanical therapy such as root planing, scaling, deep pocket debridement and antimicrobial chemotherapy as an…
View article: Space Medicine: Gut Microbiome of Hardy Species is a Potential Source to Counter Disorders During Space Travel
Space Medicine: Gut Microbiome of Hardy Species is a Potential Source to Counter Disorders During Space Travel Open
It is proposed that gut microbiome of species like cockroaches may offer a potential source of novel mechanisms/molecules that can be translated into humans to safeguard astronauts against stressors of the space environment during deep spa…
View article: Mass Spectrometric Analysis of Bioactive Conditioned Media of Bacteria Isolated From Reptilian Gut
Mass Spectrometric Analysis of Bioactive Conditioned Media of Bacteria Isolated From Reptilian Gut Open
Antibacterial assays revealed that conditioned media showed potent effects against pathogenic Gram-positive and Gram-negative bacteria. LC-MS revealed identity of 210 metabolites. The abundant metabolites were, N-Acetyl-L-tyrosine, Acetami…
View article: Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype
Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype Open
Water monitor lizards (WMLs) reside in unhygienic and challenging ecological surroundings and are routinely exposed to various pathogenic microorganisms. It is possible that their gut microbiota produces substances to counter microbial inf…
View article: Antibacterial Properties of Ethacridine Lactate and Sulfmethoxazole Loaded Functionalized Graphene Oxide Nanocomposites
Antibacterial Properties of Ethacridine Lactate and Sulfmethoxazole Loaded Functionalized Graphene Oxide Nanocomposites Open
The emergence of drug-resistant bacterial strains that reduce the effectiveness of antimicrobial agents has become a major ongoing health concern in recent years. It is therefore necessary to find new antibacterials with broad-spectrum act…
View article: Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties
Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties Open
Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system. In the absence of effective treatments, there is a need to either deve…
View article: Acute Stress and Gut Microbiome: a Potential <i>In Vivo</i> Rodent Model to Study Molecular and Pathological Mechanisms
Acute Stress and Gut Microbiome: a Potential <i>In Vivo</i> Rodent Model to Study Molecular and Pathological Mechanisms Open
View article: Can Acanthamoeba Harbor Monkeypox Virus?
Can Acanthamoeba Harbor Monkeypox Virus? Open
Acanthamoeba is well known to host a variety of microorganisms such as viruses, bacteria, protozoa, and yeast. Given the recent number of cases of monkeypox infection, we speculate that amoebae may be aiding viral transmission to the susce…