Razia F. Naeem
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View article: Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma
Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma Open
In pancreatic ductal adenocarcinoma (PDAC), glutamine is a critical nutrient that drives a wide array of metabolic and biosynthetic processes that support tumor growth. Despite this established dependency, the targeting of specific enzymes…
View article: Illuminating histidine phosphorylation in the pancreatic tumor microenvironment
Illuminating histidine phosphorylation in the pancreatic tumor microenvironment Open
Development of phosphohistidine (pHis) antibodies has significantly advanced our understanding of pHis contributions to tumor biology, including a tumor suppressive role for a pHis phosphatase, a metastasis suppressive role for His kinases…
View article: Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression
Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression Open
Our analyses identify key changes in eicosanoid species during pancreatic tumorigenesis and the cell types that contribute to their synthesis. Thromboxane and prostacyclin expression is conserved between animal models and human disease and…
View article: Eicosanoids in the pancreatic tumor microenvironment – a multicellular, multifaceted progression
Eicosanoids in the pancreatic tumor microenvironment – a multicellular, multifaceted progression Open
Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. To identify eicosanoids relevant to pancreatic tumorigenesis, we profiled normal pancreas and pancreatic ductal adenoc…
View article: Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis
Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis Open
Chronic pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma (PDA), is a serious, widespread medical condition characterized by inflammation, fibrosis, and acinar to ductal metaplasia (ADM). ADM is a ce…
View article: Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling
Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling Open
Despite numerous advances in our understanding of pancreatic ductal adenocarcinoma (PDA) genetics and biology, this disease is expected to become the second leading cause of cancer-related U.S. deaths within the next few years. Incomplete …