Roy Taylor
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View article: Continuous Glucose Monitoring Metrics and Pregnancy Outcomes in Women With Gestational Diabetes Mellitus: A Secondary Analysis of the DiGest Trial
Continuous Glucose Monitoring Metrics and Pregnancy Outcomes in Women With Gestational Diabetes Mellitus: A Secondary Analysis of the DiGest Trial Open
OBJECTIVE Continuous glucose monitoring (CGM) is increasingly used in gestational diabetes mellitus (GDM), but optimal metrics, ranges, and targets in this population are undefined. We assessed associations between CGM metrics and pregnanc…
View article: Continuous glucose monitoring metrics and pregnancy outcomes in women with gestational diabetes: a secondary analysis of the DiGest trial
Continuous glucose monitoring metrics and pregnancy outcomes in women with gestational diabetes: a secondary analysis of the DiGest trial Open
OBJECTIVE: Continuous glucose monitoring (CGM) is increasingly used in gestational diabetes mellitus (GDM) but optimal metrics, ranges and targets in this population are undefined. We assessed associations between CGM metrics and pregnancy…
View article: Continuous glucose monitoring metrics and pregnancy outcomes in women with gestational diabetes: a secondary analysis of the DiGest trial
Continuous glucose monitoring metrics and pregnancy outcomes in women with gestational diabetes: a secondary analysis of the DiGest trial Open
OBJECTIVE: Continuous glucose monitoring (CGM) is increasingly used in gestational diabetes mellitus (GDM) but optimal metrics, ranges and targets in this population are undefined. We assessed associations between CGM metrics and pregnancy…
View article: Aetiology of type 2 diabetes: an experimental medicine odyssey
Aetiology of type 2 diabetes: an experimental medicine odyssey Open
This review describes a prolonged research endeavour to test the twin cycle hypothesis that type 2 diabetes is caused by fat-induced dysfunction of the liver and pancreas, guided by the happenstance of clinical practice. Testing of the per…
View article: The Twin Cycle Hypothesis of type 2 diabetes aetiology: From concept to national NHS programme
The Twin Cycle Hypothesis of type 2 diabetes aetiology: From concept to national NHS programme Open
The development of magnetic resonance methods for quantifying intra‐organ metabolites has permitted advances in the understanding of fasting and post‐prandial carbohydrate and lipid handling in people with and without type 2 diabetes. Insu…
View article: Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial
Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial Open
Reduced-energy diets promote weight loss and improve long-term outcomes in type 2 diabetes but are untested in gestational diabetes. We aimed to identify if weight loss in pregnancy improves perinatal outcomes in gestational diabetes. We p…
View article: Clinical utility of liver function tests for resolution of metabolic dysfunction‐associated steatotic liver disease after weight loss in the Diabetes Remission Clinical Trial
Clinical utility of liver function tests for resolution of metabolic dysfunction‐associated steatotic liver disease after weight loss in the Diabetes Remission Clinical Trial Open
Aims Ectopic fat is reduced by effective weight management, but difficult to assess clinically. Methods We evaluated paired data on 42 participants in the intervention group of the Diabetes Remission Clinical Trial (DiRECT) at baseline, 12…
View article: Early findings from the NHS Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation
Early findings from the NHS Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation Open
None.
View article: 257-OR: ADA Presidents' Select Abstract: The Effect of a Reduced-Energy Diet upon Maternal Weight and Pregnancy Outcomes in Women with Gestational Diabetes—The DiGest Trial
257-OR: ADA Presidents' Select Abstract: The Effect of a Reduced-Energy Diet upon Maternal Weight and Pregnancy Outcomes in Women with Gestational Diabetes—The DiGest Trial Open
Background: Reduced-energy diets improve clinical outcomes in type 2 diabetes but are untested in gestational diabetes. Methods: In a randomized, controlled, double-blind, whole-diet replacement trial (ISRCTN; 37866), women with gestationa…
View article: 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study Open
Diabetes UK.
View article: When is HbA1c useful and what do the numbers mean – do they help or hinder?
When is HbA1c useful and what do the numbers mean – do they help or hinder? Open
Background: Glycated haemoglobin (HbA1c) measurement is used for diagnosis, management and remission of type 2 diabetes (T2DM), with measurements comparable worldwide and the World Health Organization listing medical conditions that affect…
View article: The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT) Open
Aims/hypothesis High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic patterns can be …
View article: Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission
Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission Open
OBJECTIVE To determine the extent to which changes in plasma proteins, previously predictive of cardiometabolic outcomes, predict changes in two diabetes remission trials. RESEARCH DESIGN AND METHODS We applied SomaSignal predictive tests …
View article: Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission
Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission Open
Objective: To determine to what extent changes in plasma proteins, previously predictive of cardiometabolic outcomes, predict changes in two diabetes remission trials.Research Design and Methods: SomaSignal® predictive tests (each derived …
View article: Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission
Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission Open
Objective: To determine to what extent changes in plasma proteins, previously predictive of cardiometabolic outcomes, predict changes in two diabetes remission trials.Research Design and Methods: SomaSignal® predictive tests (each derived …
View article: Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis
Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis Open
Weight loss in overweight or obese individuals with Type 2 diabetes (T2D) can normalize hepatic fat metabolism, decrease fatty acid oversupply to β cells and restore normoglycaemia. One in six people has BMI <27 kg/m2 at diagnosis, and …
View article: Using trials of caloric restriction and bariatric surgery to explore the effects of adiposity on the circulating proteome
Using trials of caloric restriction and bariatric surgery to explore the effects of adiposity on the circulating proteome Open
Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with weight. We aimed to identify consistent protein …
View article: What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss
What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss Open
Background Type 2 diabetes (T2D) is often regarded as a progressive, lifelong disease requiring an increasing number of drugs. Sustained remission of T2D is now well established, but is not yet routinely practised. Norwood surgery has used…
View article: Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (<scp>DiRECT</scp>)
Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (<span>DiRECT</span>) Open
Aims As sustained weight loss is vital for achieving remission of type 2 diabetes, we explored whether randomisation to weight loss plus maintenance in the DiRECT trial was associated with physical activity, inactivity or sleep. Methods Pa…
View article: The metabolomic signature of weight loss in the Diabetes Remission Clinical Trial (DiRECT)
The metabolomic signature of weight loss in the Diabetes Remission Clinical Trial (DiRECT) Open
Use of high-throughput metabolomics technologies in a variety of study designs has demonstrated a strong and consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic patterns can be…