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View article: Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling Open
Organisms have evolved protective strategies that are geared toward limiting cellular damage and enhancing organismal survival in the face of environmental stresses, but how these protective mechanisms are coordinated remains unclear. Here…
View article: Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling Open
Organisms have evolved protective strategies that are geared toward limiting cellular damage and enhancing organismal survival in the face of environmental stresses, but how these protective mechanisms are coordinated remains unclear. Here…
View article: Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling Open
Organisms have evolved protective strategies that are geared toward limiting cellular damage and enhancing organismal survival in the face of environmental stresses, but how these protective mechanisms are coordinated remains unclear. Here…
View article: Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity
Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity Open
Innate immunity in bacteria, plants, and animals requires the specialized subset of Toll/interleukin-1/resistance gene (TIR) domain proteins that are nicotinamide adenine dinucleotide (NAD+) hydrolases. Aggregation of these TIR proteins en…
View article: Lysosomal integrity suppresses TIR-1/SARM1 aggregation to restrain toxic propagation of p38 innate immunity
Lysosomal integrity suppresses TIR-1/SARM1 aggregation to restrain toxic propagation of p38 innate immunity Open
SUMMARY Innate immunity in bacteria, plants and animals requires the specialized subset of TIR-domain proteins that are NAD + hydrolases. Aggregation of these TIR proteins engages their enzymatic activity, but it is not known how this prot…
View article: Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans
Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans Open
Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not known. Here we characterize a transcriptional axis that regul…
View article: Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in<i>C. elegans</i>
Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in<i>C. elegans</i> Open
Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not known. Here we characterize a transcriptional axis that regul…
View article: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favora…
View article: Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abs…
View article: Bacterial pattern recognition in <i>C. elegans</i> by a nuclear hormone receptor
Bacterial pattern recognition in <i>C. elegans</i> by a nuclear hormone receptor Open
SUMMARY Pattern recognition of bacterial products by host receptors is essential for innate immunity in many metazoans. Curiously, the nematode lineage lost canonical mechanisms of bacterial pattern recognition. Whether other immune recept…
View article: Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition
Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition Open
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the…
View article: Author response: Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition
Author response: Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Intracell…
View article: Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms in <i>Caenorhabditis elegans</i>
Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms in <i>Caenorhabditis elegans</i> Open
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicati…
View article: A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the <i>C. elegans</i> intestine
A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the <i>C. elegans</i> intestine Open
Intracellular signaling regulators can be concentrated into membrane-free, higher-ordered protein assemblies to initiate protective responses during stress — a process known as phase transition. Here, we show that a phase transition of the…
View article: Peripherally Inserted Central Catheter-Associated <i>Nocardia nova</i> Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease
Peripherally Inserted Central Catheter-Associated <i>Nocardia nova</i> Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease Open
Long-term antibiotics are not effective for the therapy of patients with persistent symptoms and a history of Lyme disease. However, some clinicians still prescribe these therapies. We present a case of peripherally inserted central cathet…
View article: Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection Open
Early host responses toward pathogens are essential for defense against infection. In Caenorhabditis elegans , the transcription factor, SKN-1, regulates cellular defenses during xenobiotic intoxication and bacterial infection. However, co…
View article: The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans
The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans Open
Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the monounsaturated fatty acid oleate in the innate immune response o…
View article: Mitochondrial UPR repression during <i>Pseudomonas aeruginosa</i> infection requires the bZIP protein ZIP-3
Mitochondrial UPR repression during <i>Pseudomonas aeruginosa</i> infection requires the bZIP protein ZIP-3 Open
Mitochondria generate most cellular energy and are targeted by multiple pathogens during infection. In turn, metazoans employ surveillance mechanisms such as the mitochondrial unfolded protein response (UPR mt ) to detect and respond to mi…
View article: The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans Open
Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host responses following recognition of specific endogenous or exogenous ligands. Although NHRs have expanded dramatically in C. elegans compared…
View article: Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine Open
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is hypothesized to link metabolism and chromatin modification, however, its role in acu…
View article: Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to <i>Caenorhabditis elegans</i>
Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to <i>Caenorhabditis elegans</i> Open
Inappropriate activation of innate immune responses in intestinal epithelial cells underlies the pathophysiology of inflammatory disorders of the intestine. Here we examine the physiological effects of immune hyperactivation in the intesti…