Rebeca T. Stiepel
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View article: Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine
Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine Open
View article: Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression
Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression Open
Development of tolerogenic microparticle (MP) therapy made of acetalated dextran and loaded with antigenic peptide and tolerizing drug rapamycin (Rapa) to address problems with Multiple Sclerosis (MS) autoimmune disease.
View article: Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine
Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine Open
Influenza virus is a major cause of death on a global scale. Seasonal vaccines have been developed to combat influenza; however, they are not always highly effective. One strategy to develop a more broadly active influenza vaccine is the u…
View article: Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles
Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles Open
A comprehensive comparison between emulsion and spray methods for the fabrication of rapamycin-loaded Ace-DEX MPs, investigating physiochemical parameters, in vitro immunosuppressive efficacy, and in vivo trafficking. Rapamycin (rapa), an …
View article: Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications
Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications Open
Previously, high-aspect- ratio ribbon-like microconfetti (MC) composed of acetalated dextran (Ace-DEX) have been shown to form a subcutaneous depot for sustained drug release. In this study, MC were explored as an injectable vaccine platfo…
View article: Metal-Organic Coordination Polymer for Delivery of a Subunit Broadly Acting Influenza Vaccine
Metal-Organic Coordination Polymer for Delivery of a Subunit Broadly Acting Influenza Vaccine Open
A zinc-carnosine (ZnCar) metal-organic coordination polymer was fabricated in biologically relevant N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid (HEPES) buffer for use as a vaccine platform. In vitro, ZnCar exhibited significantly l…
View article: Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine
Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine Open
View article: Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles
Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles Open
A comprehensive comparison between emulsion and spray methods for the fabrication of rapamycin-loaded Ace-DEX MPs, investigating physiochemical parameters, in vitro immunosuppressive efficacy, and in vivo trafficking.
View article: Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations
Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations Open
Influenza virus outbreaks are a major burden worldwide each year. Current vaccination strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low immune responses. The use of computationally optimized bro…
View article: Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG
Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG Open
Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to better combat respiratory infections such as influenza. Mast cells (MCs) are emerging as a target for a new class of mucosal vaccine adjuvants. Here, w…
View article: Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG
Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG Open
Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to better combat respiratory infections such as influenza. Mast cells (MCs) are emerging as a target for a new class of mucosal vaccine adjuvants. Here, w…
View article: Single-tailed heterocyclic carboxamide lipids for macrophage immune-modulation
Single-tailed heterocyclic carboxamide lipids for macrophage immune-modulation Open
New lipids are of great interest for drug/gene delivery. We discovered single-tailed heterocyclic carboxamide lipids for stimulating S1P lysate and IFN-alpha responses in macrophages, providing new bioactive lipid biomaterials for immune m…
View article: Micro and nanotechnologies: The little formulations that could
Micro and nanotechnologies: The little formulations that could Open
The first publication of micro‐ and nanotechnology in medicine was in 1798 with the use of the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then, there has been an explosion of micro‐ and nanotechnologies …
View article: A predictive mechanistic model of drug release from surface eroding polymeric nanoparticles
A predictive mechanistic model of drug release from surface eroding polymeric nanoparticles Open
View article: Metal–Organic Coordination Polymer for Delivery of a Subunit Broadly Acting Influenza Vaccine
Metal–Organic Coordination Polymer for Delivery of a Subunit Broadly Acting Influenza Vaccine Open
Using polymers to deliver broadly reactive influenza subunit vaccines
View article: Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine
Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine Open
Intranasal immunization of mice using COBRA H1 with stimulator of interferon genes (STING)-cGAMP gel formulation against influenza.
View article: Dexamethasone and Fumaric Acid Ester Conjugate Synergistically Inhibits Inflammation and NF-κB in Macrophages
Dexamethasone and Fumaric Acid Ester Conjugate Synergistically Inhibits Inflammation and NF-κB in Macrophages Open
Macrophage-mediated inflammation drives autoimmune and chronic inflammatory diseases. Treatment with anti-inflammatory agents can be an effective strategy to reduce this inflammation; however, high concentrations of these agents can have i…
View article: Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications
Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications Open
Previously, high-aspect- ratio ribbon-like microconfetti (MC) composed of acetalated dextran (Ace-DEX) have been shown to form a subcutaneous depot for sustained drug release. In this study, MC were explored as an injectable vaccine platfo…