Explanipedia

BIOM-113. TERT EXPRESSION IN MENINGIOMAS PREDICTS PROGRESSION-FREE SURVIVAL INDEPENDENT OF TERT PROMOTER MUTATION Open

Chloe Gui, Justin Wang, Vikas Patil, Alexander Landry, Olivia Singh , et al. · 2025

INTRODUCTION While TERT promoter mutation (TPM) has been established as a marker of clinically aggressive meningiomas, this alteration is rare and found in less than 5% of all cases. However, a larger subset of meningiomas may exhibit aber…

BIOM-113. TERT EXPRESSION IN MENINGIOMAS PREDICTS PROGRESSION-FREE SURVIVAL INDEPENDENT OF TERT PROMOTER MUTATION Open

Chloe Gui, Justin Q. Wang, Vikas Patil, Alexander Landry, Olivia Singh , et al. · 2025

INTRODUCTION While TERT promoter mutation (TPM) has been established as a marker of clinically aggressive meningiomas, this alteration is rare and found in less than 5% of all cases. However, a larger subset of meningiomas may exhibit aber…

Dermatologic Mimickers of Paget’s Disease of the Breast: A Systematic Review Open

Emily Volfson, Michal Moshkovich, Rebeca Yakubov, Jaycie Dalson, Carly Kirshen · 2025

Mammary Paget disease (MPD) is a rare form of breast cancer that accounts for just 1% to 4% of all cases and is often associated with underlying malignancies such as ductal carcinoma in situ and invasive ductal carcinoma. Its clinical pres…

33 TERT EXPRESSION PREDICTS PROGRESSION-FREE SURVIVAL IN MENINGIOMAS Open

Chloe Gui, Justin Z. Wang, Vikas Patil, Alexander Landry, Pedro Castelo‐Branco , et al. · 2025

BACKGROUND TERT promoter mutation (TPM) is a rare but established biomarker in meningiomas associated with aberrant TERT expression and reduced progression-free survival (PFS). While TERT is highly expressed in meningiomas with TPMs, it ha…

P.157 TERT expression predicts progression-free survival in meningiomas Open

Chloe Gui, JZ Wang, Vikas Patil, AP Landry, Pedro Castelo‐Branco , et al. · 2025

Background: TERT promoter mutation (TPM) is an established biomarker in meningiomas associated with aberrant TERT expression and reduced progression-free survival (PFS). TERT expression, however, has also been observed even in tumours with…

The impact of preexisting psychiatric disorders on patient outcomes following primary total shoulder arthroplasty: A systematic review and quantitative synthesis Open

Bryan Sun, Vetri Thangavelu, Rebeca Yakubov, Clare Sun, Moin Khan , et al. · 2025

Purpose To summarize complication rates, reoperation rates, length-of-stay (LOS), patient-reported outcome measures (PROMs), and range of motion following total shoulder arthroplasty (TSA) in patients with preexisting psychiatric disorders…

It’s all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma Open

Rebeca Yakubov, Ramneet Kaloti, Phooja Persaud, Alison N. McCracken, Gelareh Zadeh , et al. · 2025

Transcription factors are promising targets for overcoming treatment resistance in GBM, with cotreatment strategies combining RTK/Ras/Raf/MEK/ERK pathway inhibitors and transcription factor-targeted therapies presenting a novel approach. D…

Stratification of surgical outcomes in trigeminal neuralgia using multimodal data Open

Timur Latypov, Rebeca Yakubov, Daniel Jörgens, Pascale Tsai, Patcharaporn Srisaikaew , et al. · 2025

Chronic pain remains a challenge for clinicians, with limited individualized predictive tools that can aid with diagnosis, disease course, or prediction of treatment outcomes. We hypothesized that a comprehensive analysis, encompassing a p…

Signatures of chronic pain in multiple sclerosis: a machine learning approach to investigate trigeminal neuralgia Open

Timur Latypov, Abigail Wolfensohn, Rebeca Yakubov, Vassilia Michailidis, Patcharaporn Srisaikaew , et al. · 2024

Chronic pain is a pervasive, disabling, and understudied feature of multiple sclerosis (MS), a progressive demyelinating and neurodegenerative disease. Current focus on motor components of MS disability combined with difficulties assessing…

Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma Open

Justin Z. Wang, Vikas Patil, Alexander Landry, Chloe Gui, Andrew Ajisebutu , et al. · 2024

GR.6 Meningioma molecular classification predicts response to surgery and adjuvant radiotherapy: an integrated clinicomolecular analysis & prospective validation Open

JZ Wang, AP Landry, Vikas Patil, Jin Liu, Andrew Ajisebutu , et al. · 2024

Background: Meningiomas are the most common intracranial tumor with surgery, dural margin treatment, and radiotherapy as cornerstones of therapy. Response to treatment continues to be highly heterogeneous even across tumors of the same gra…

CSIG-03. SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOUR PROGRESSION IN MPNST Open

Rebeca Yakubov, Severa Bunda, Gelareh Zadeh · 2023

BACKGROUND Malignant peripheral nerve sheath tumours (MPNST) are highly aggressive sarcomas with little progress on outcomes and treatment strategies. Previous work conducted in our lab used unsupervised analyses of methylome and transcrip…

CSIG-02. SHH PATHWAY ACTIVATION DRIVES NEURAL CREST CELL SIGNATURE IN A SUBGROUP OF MPNSTS Open

Suganth Suppiah, Jeffrey Liu, Mira Li, Mohsen Heidari, Rebeca Yakubov , et al. · 2023

INTRODUCTION Neurofibromatosis Type 1 is hereditary tumor predisposition syndrome that results in the development of innumerable nerve sheath tumors that fall within the spectrum of benign, premalignant and malignant lesions. Our previous …

PATH-52. MENINGIOMA MOLECULAR GROUPS PREDICT RESPONSE TO SURGERY AND RADIOTHERAPY Open

Justin Z. Wang, Vikas Patil, Alexander Landry, Andrew Ajisebutu, Jeff Liu , et al. · 2023

INTRODUCTION Aside from surgery, radiotherapy (RT) remains the only accepted treatment for meningiomas. However, patient selection for adjuvant RT remains controversial. We aimed to evaluate whether novel molecular and methylation groups c…

SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOR PROGRESSION IN MPNST Open

Rebeca Yakubov, Severa Bunda, G Z Zadeh · 2023

Malignant peripheral nerve sheath tumours (MPNST) are highly aggressive sarcomas with little progress on outcomes and treatment strategies. Previous work conducted in our lab used unsupervised analyses of methylome and transcriptome profil…

F.3 Comprehensive multiplatform analysis of CDKN2A alterations in meningiomas Open

JZ Wang, V Patil, Jingyu Liu, Helin Dogan, Ghazaleh Tabatabai , et al. · 2023

Background: In meningiomas, CDKN2A/B deletions are associated with poor outcomes but are rare in most cohorts (1-5%). Large molecular datasets are therefore required to explore these deletions and their relationship to other prognostic CDK…

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