Rebecca A. Gillespie
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View article: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity Open
HIV-1 continues to pose a significant global health challenge, requiring ongoing research into effective prevention and treatment strategies. Understanding the B-cell repertoire that can be engaged upon vaccination in humans is crucial for…
View article: From sequence to scaffold: Computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks
From sequence to scaffold: Computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks Open
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and durability. Computational protein design …
View article: Generation of antigen-specific paired-chain antibodies using large language models
Generation of antigen-specific paired-chain antibodies using large language models Open
The traditional process of antibody discovery is limited by inefficiency, high costs, and low success rates. Recent approaches employing artificial intelligence (AI) have been developed to optimize existing antibodies and generate antibody…
View article: Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses Open
View article: From sequence to scaffold: computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks
From sequence to scaffold: computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks Open
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and durability. Computational protein design …
View article: Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses
Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses Open
Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influenza viruses adapted to transmission in …
View article: Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies
Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies Open
View article: Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies
Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies Open
The regular emergence of influenza strains with pandemic potential creates a strong incentive to develop vaccines that stimulate protective responses across all human populations. A critical consideration is how variation in the human immu…
View article: Consumer and Stakeholder Perceptions of Urban-Grown Food
Consumer and Stakeholder Perceptions of Urban-Grown Food Open
View article: Antibody function predicts viral control in newborn monkeys immunised with an influenza virus HA stem nanoparticle
Antibody function predicts viral control in newborn monkeys immunised with an influenza virus HA stem nanoparticle Open
View article: Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques
Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques Open
SUMMARY Human B cell immunity to the influenza hemagglutinin (HA) stem region, a universal influenza vaccine target, is often stereotyped and immunogenetically restricted, posing challenges for study outside humans. Here, we show that maca…
View article: Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity Open
HIV-1 continues to pose a significant global health challenge, requiring ongoing research into effective prevention and treatment strategies. Understanding the B cell repertoire that can be engaged upon vaccination in humans is crucial for…
View article: Generation of antigen-specific paired chain antibody sequences using large language models
Generation of antigen-specific paired chain antibody sequences using large language models Open
The traditional process of antibody discovery is limited by inefficiency, high costs, and low success rates. Recent approaches employing artificial intelligence (AI) have been developed to optimize existing antibodies and generate antibody…
View article: Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies Open
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the urgent need for pandemic preparedn…
View article: Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem
Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem Open
Antibodies targeting epitopes through germline-encoded motifs can be found in different individuals. While these public antibodies are often beneficial, they also pose hurdles for subdominant antibodies to emerge. Here, we use transgenic m…
View article: Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine
Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine Open
View article: Antibody sequence determinants of viral antigen specificity
Antibody sequence determinants of viral antigen specificity Open
Throughout life, humans experience repeated exposure to viral antigens through infection and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires. A paramount feature of antibodies that enables their c…
View article: Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody
Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody Open
The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort…
View article: Immune memory shapes human polyclonal antibody responses to H2N2 vaccination
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination Open
Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed ad…
View article: Does urban agriculture contribute to food security, and how might this be achieved?
Does urban agriculture contribute to food security, and how might this be achieved? Open
Objective: Food system challenges exacerbate inequalities in access to fresh healthy food and threaten food security. Lack of food security, referred to as food insecurity, is associated with poorer physical and mental health outcomes and …
View article: Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase Open
View article: Antigen spacing on protein nanoparticles influences antibody responses to vaccination
Antigen spacing on protein nanoparticles influences antibody responses to vaccination Open
View article: Citizen Science for Food Standards Challenges: Programme Review
Citizen Science for Food Standards Challenges: Programme Review Open
Citizen science is an umbrella term that describes a variety of ways in which members of the public can participate in science. The main characteristics of the approach are that: citizens are actively involved in research, in partnership o…
View article: Convergent Sequence Features of Antiviral B Cells
Convergent Sequence Features of Antiviral B Cells Open
SUMMARY Throughout life, humans experience repeated exposure to viral antigens through infection and vaccination, building diverse antigen-specific antibody repertoires. In recent years, these repertoires have become an important source fo…
View article: Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures
Refined semi-lethal aerosol H5N1 influenza model in cynomolgus macaques for evaluation of medical countermeasures Open
Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines and treatments against this threat are urgently needed. Here, we have refined our previously established model …
View article: Immune memory shapes human polyclonal antibody responses to H2N2 vaccination
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination Open
Summary Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase I clinical trial investigating a ferritin nanoparticle displaying H2 hemagglutinin in H2-naïve and H2-exposed adults.…
View article: C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire
C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire Open
Broadly neutralizing, anti-hemagglutinin stem antibodies (Abs) are a promising universal influenza vaccine target. While anti-stem Abs are not believed to block viral attachment, we show that C1q confers attachment inhibition and boosts fu…
View article: Antigen spacing on protein nanoparticles influences antibody responses to vaccination
Antigen spacing on protein nanoparticles influences antibody responses to vaccination Open
SUMMARY Immunogen design approaches aim to control the specificity and quality of antibody responses to enable the creation of next-generation vaccines with improved potency and breadth. However, our understanding of the relationship betwe…
View article: The complement protein C1q modulates the activities of anti-influenza HA-stem and anti-SARS-Cov2-nonRBD antibodies and alters viral evolution
The complement protein C1q modulates the activities of anti-influenza HA-stem and anti-SARS-Cov2-nonRBD antibodies and alters viral evolution Open
The broadly neutralizing hemagglutinin (BN-HA) stem antibodies represent an universal vaccine prospect. However, our understanding of how these antibodies interact with the influenza virus is limited by excluding other immune elements, suc…
View article: Digital methods of social science in food regulation: case studies from the Food Standards Agency
Digital methods of social science in food regulation: case studies from the Food Standards Agency Open
The use of digital methods in social research has increased significantly, offering some benefits over traditional research methods, and some new challenges. The UK Food Standards Agency’s social science provides several case studies of ho…