Rebecca A. Wright
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View article: Seascape connectivity: evidence, knowledge gaps and implications for temperate coastal ecosystem restoration practice and policy
Seascape connectivity: evidence, knowledge gaps and implications for temperate coastal ecosystem restoration practice and policy Open
Temperate coastal marine ecosystems have undergone severe global loss and degradation. We provide a framework for considering ecological connectivity in marine systems and evidence for ecological connectivity across temperate coastal seasc…
View article: Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission Open
View article: Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission Open
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, about half of t…
View article: CCDC 1944255: Experimental Crystal Structure Determination
CCDC 1944255: Experimental Crystal Structure Determination Open
View article: CCDC 1944256: Experimental Crystal Structure Determination
CCDC 1944256: Experimental Crystal Structure Determination Open
View article: CCDC 1944257: Experimental Crystal Structure Determination
CCDC 1944257: Experimental Crystal Structure Determination Open
View article: Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1<i>S</i>,3<i>R</i>)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1<i>S</i>,3<i>R</i>)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor Open
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (3) as a novel, potent, and subtype selecti…
View article: Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus Open
Benzodiazepine-resistant status epilepticus is an ongoing clinical challenge. Burman et al. show that longer seizure duration is a useful clinical indicator of benzodiazepine resistance, and that resistance is caused by changes in GABAA re…
View article: Excitatory GABAergic signalling is associated with acquired benzodiazepine resistance in status epilepticus
Excitatory GABAergic signalling is associated with acquired benzodiazepine resistance in status epilepticus Open
Status epilepticus (SE) is defined as a state of unrelenting seizure activity. Generalised convulsive SE is associated with a rapidly rising mortality rate, and thus constitutes a medical emergency. Benzodiazepines, which act as positive m…
View article: In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography Open
View article: Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA<sub>B</sub>Receptor Protein Complex
Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA<sub>B</sub>Receptor Protein Complex Open
GABA B receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABA B receptor forms part of larger signaling complexes, whi…
View article: An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis Open
View article: Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals Open
View article: Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency
Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency Open
Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environ…
View article: REST Regulates Non–Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II
REST Regulates Non–Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II Open
RE-1 silencing transcription factor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preventing the differentiation of neural stem cells. Here we focused on the role of REST in the early steps of di…
View article: Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs Open
View article: The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors Open
View article: SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis
SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis Open
Significance Sex-determining region Y-related HMG box 2 (SOX2) is a well-established marker of neural stem and progenitor cells, and its function was shown to be required for the self-renewal of these cells. However, the function of SOX2 i…