Rebecca Croasdale-Wood
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View article: Accelerating antibody development: sequence and structure-based models for predicting developability properties via size exclusion chromatography
Accelerating antibody development: sequence and structure-based models for predicting developability properties via size exclusion chromatography Open
Experimental screening for biopharmaceutical developability properties typically relies on resource-intensive, and time-consuming assays such as size exclusion chromatography (SEC). This study highlights the potential of in silico models t…
View article: Mask-prior-guided denoising diffusion improves inverse protein folding
Mask-prior-guided denoising diffusion improves inverse protein folding Open
Inverse protein folding generates valid amino acid sequences that can fold into a desired protein structure, with recent deep learning advances showing strong potential and competitive performance. However, challenges remain, such as predi…
View article: How to think about designing smart antibodies in the age of genAI: integrating biology, technology, and experience
How to think about designing smart antibodies in the age of genAI: integrating biology, technology, and experience Open
Antibody discovery has been successful in designing and progressing molecules to the clinic and market based on largely empirical methods and human experience. The field is now transitioning from classical monospecific antibodies to innova…
View article: Accelerating Antibody Development: Sequence and Structure-Based Models for Predicting Developability Properties through Size Exclusion Chromatography
Accelerating Antibody Development: Sequence and Structure-Based Models for Predicting Developability Properties through Size Exclusion Chromatography Open
Experimental screening for biopharmaceutical developability properties typically relies on resource-intensive, and time-consuming assays such as size exclusion chromatography (SEC). This study highlights the potential of in silico models t…
View article: Mask prior-guided denoising diffusion improves inverse protein folding
Mask prior-guided denoising diffusion improves inverse protein folding Open
Inverse protein folding generates valid amino acid sequences that can fold into a desired protein structure, with recent deep-learning advances showing strong potential and competitive performance. However, challenges remain, such as predi…
View article: p-IgGen: a paired antibody generative language model
p-IgGen: a paired antibody generative language model Open
Summary A key challenge in antibody drug discovery is designing novel sequences that are free from developability issues—such as aggregation, polyspecificity, poor expression, or low solubility. Here, we present p-IgGen, a protein language…
View article: Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen
Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen Open
Over the past two decades, therapeutic antibodies have emerged as a rapidly expanding domain within the field of biologics. In silico tools that can streamline the process of antibody discovery and optimization are critical to support a pi…
View article: Improving Antibody Humanness Prediction using Patent Data
Improving Antibody Humanness Prediction using Patent Data Open
We investigate the potential of patent data for improving the antibody humanness prediction using a multi-stage, multi-loss training process. Humanness serves as a proxy for the immunogenic response to antibody therapeutics, one of the maj…
View article: Enhancement of antibody thermostability and affinity by computational design in the absence of antigen
Enhancement of antibody thermostability and affinity by computational design in the absence of antigen Open
Over the last two decades, therapeutic antibodies have emerged as a rapidly expanding domain within the field biologics. In silico tools that can streamline the process of antibody discovery and optimization are critical to support a pipel…