Rebecca D. Huffstutler
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View article: Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study
Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study Open
Background Psoriasis is a chronic inflammatory disease associated with multiple comorbidities, including metabolic syndrome and cardiovascular disease. Although specific dietary interventions, such as intermittent fasting and caloric restr…
View article: Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC)
Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC) Open
Background: Arterial calcification due to deficiency of CD73 (ACDC; OMIM 211800) is a rare genetic disease resulting in calcium deposits in arteries and small joints causing claudication, resting pain, severe joint pain, and deformities. C…
View article: Nicotinamide Riboside Augments Human Macrophage Migration via SIRT3-Mediated Prostaglandin E2 Signaling
Nicotinamide Riboside Augments Human Macrophage Migration via SIRT3-Mediated Prostaglandin E2 Signaling Open
NAD+ boosting via nicotinamide riboside (NR) confers anti-inflammatory effects. However, its underlying mechanisms and therapeutic potential remain incompletely defined. Here, we showed that NR increased the expression of CC-chemokine rece…
View article: The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon<i>via</i>epigenetic control
The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon<i>via</i>epigenetic control Open
Lipid-derived acetyl-CoA is shown to be the major carbon source for histone acetylation. However, there is no direct evidence demonstrating lipid metabolic pathway contribututions to this process. Mitochondrial acetyl-CoA acetyltransferase…
View article: Propionate functions as a feeding state–dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity
Propionate functions as a feeding state–dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity Open
Generally, fasting and refeeding confer anti- and proinflammatory effects, respectively. In humans, these caloric-load interventions function, in part, via regulation of CD4+ T cell biology. However, mechanisms orchestrating this regulatio…
View article: Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects Open
View article: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome Open
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by various disabling symptoms including exercise intolerance and is diagnosed in the absence of a specific cause, making its clinical management challenging. A be…
View article: Boosting NAD blunts TH17 inflammation via arginine biosynthesis and redox regulatory control in healthy control and psoriasis human subjects
Boosting NAD blunts TH17 inflammation via arginine biosynthesis and redox regulatory control in healthy control and psoriasis human subjects Open
Although NAD+ levels modulate metabolism, how this regulates immunometabolism/inflammation remains unclear. Employing Nicotinamide Riboside (NR) to boost NAD, we explored TH17-linked inflammatory in Psoriasis. Primary Psoriasis CD4+ T cell…
View article: N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness
N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness Open
Caloric deprivation interventions such as intermittent fasting and caloric restriction ameliorate metabolic and inflammatory disease. As a human model of caloric deprivation, a 24-h fast blunts innate and adaptive immune cell responsivenes…
View article: Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness Open
Intermittent fasting and fasting mimetic diets ameliorate inflammation. Similarly, serum extracted from fasted healthy and asthmatic subjects’ blunt inflammation in vitro, implicating serum components in this immunomodulation. To identify …
View article: Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency
Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency Open
Objectives Arterial calcification due to deficiency of CD73 (ACDC) is a hereditary autosomal recessive ectopic mineralization syndrome caused by loss-of-function mutations in the ecto-5′-nucleotidase gene. Periarticular calcification has b…
View article: Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness
Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness Open
View article: Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome
Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome Open
Background Li-Fraumeni syndrome (LFS) is a highly penetrant autosomal dominant cancer predisposition disorder caused by germline TP53 pathogenic variants. Patients with LFS have increased oxidative phosphorylation capacity in skeletal musc…
View article: Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome
Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome Open
Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in TP53 that can lead to increased mitochondrial metabolism in patients. However, the implications of altered mitochondrial function for tumorigene…
View article: Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects Open
Division of Intramural Research, NHLBI of the NIH.