Rebecca Grande
YOU?
Author Swipe
View article: De novo assembly of RNA m6A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation
De novo assembly of RNA m6A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation Open
The factors that install and recognize N6-methyladenosine (m6A) on RNA to regulate gene expression are well characterized, but how their spatial organization responds to physiological stress, including infection, is unclear. Here, we show …
View article: Targeting the m<sup>6</sup>A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Targeting the m<sup>6</sup>A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication Open
N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of m 6 A by the nuclear RNA methyltransferase METTL3 occurs cotranscriptio…
View article: RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection
RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection Open
The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1’s high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the eff…
View article: Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses
Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses Open
[This corrects the article DOI: 10.1371/journal.ppat.1009101.].
View article: RV144 HIV-1 vaccination impacts post-infection antibody responses
RV144 HIV-1 vaccination impacts post-infection antibody responses Open
The RV144 vaccine efficacy clinical trial showed a reduction in HIV-1 infections by 31%. Vaccine efficacy was associated with stronger binding antibody responses to the HIV Envelope (Env) V1V2 region, with decreased efficacy as responses w…
View article: Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides
Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides Open
The ability to protect vulnerable populations such as pregnant women and children from Zika virus and other arbovirus infections is essential to preventing the devastating complications induced by these viruses. One class of antiviral ther…
View article: The antiparasitic drug atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides.
The antiparasitic drug atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides. Open
Arthropod-borne viruses represent a significant public health threat worldwide yet there are few antiviral therapies or prophylaxis targeting these pathogens. In particular, the development of novel antivirals for high-risk populations suc…