Rebecca J. Loomis
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View article: Structure-based design of glycoprotein subunit vaccines for mumps
Structure-based design of glycoprotein subunit vaccines for mumps Open
Mumps virus (MuV) is a highly contagious paramyxovirus that is endemic in most regions of the world and continues to cause outbreaks even in highly immunized populations. Outbreaks of mumps in countries with high measles, mumps, and rubell…
View article: Prefusion stabilization of the Hendra and Langya virus F proteins
Prefusion stabilization of the Hendra and Langya virus F proteins Open
Pathogenic henipaviruses such as Nipah virus (NiV) and Hendra virus (HeV) cause respiratory symptoms, with severe cases resulting in encephalitis, seizures, and coma. The work described here shows that the NiV and HeV fusion (F) proteins s…
View article: Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein
Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein Open
View article: 93. Novel recombinant measles virus vaccine prevents measles virus disease in rhesus macaques
93. Novel recombinant measles virus vaccine prevents measles virus disease in rhesus macaques Open
Background Measles-Mumps-Rubella (MMR) is an effective live-virus vaccine against measles virus (MeV). However, use of MMR is limited by its inability to boost MeV immunity, lack of immunogenicity in infants, and contraindication in pregna…
View article: Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein
Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein Open
SUMMARY/ABSTRACT Nipah virus (NiV) is a pathogenic paramyxovirus that causes fatal encephalitis in humans. Two envelope glycoproteins, the attachment protein (G) and fusion protein (F), facilitate entry into host cells. Due to its vital ro…
View article: A Code of Conduct Is Imperative for Ocean Carbon Dioxide Removal Research
A Code of Conduct Is Imperative for Ocean Carbon Dioxide Removal Research Open
As the impacts of rising temperatures mount and the global transition to clean energy advances only gradually, scientists and policymakers are looking towards carbon dioxide removal (CDR) methods to prevent the worst impacts of climate cha…
View article: Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine
Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine Open
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from bats-to-humans with almost annual regional outbreaks characterized by documented human-to-human transmission and high fatality rates. Currently, no …
View article: COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge Open
View article: Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Production by Modulating Exocytosis
Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Production by Modulating Exocytosis Open
RhoGTPases play important roles in the regulation of protein transport and membrane recycling. Little is known, however, about how RhoGTPases affect HIV-1 virion production, which is dependent on the endosomal sorting pathway. We report th…
View article: HIV-1 Replication and Pathogenesis in the Human Thymus
HIV-1 Replication and Pathogenesis in the Human Thymus Open
How HIV replicates and causes destruction of the thymus, and how to restore thymic function, are among the most important questions of HIV-1 pathogenesis and therapy in adult as well as pediatric patients. The thymus appears to function, a…
View article: SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness Open
View article: Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates Open
Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung. (Funded by the National Institutes of Health and other…
View article: SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness Open
Summary A SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mutations that improved expression and immunogenicity of betacoronavirus …
View article: Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development
Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development Open
Licensed vaccines or therapeutics are rarely available for pathogens with epidemic or pandemic potential. Developing interventions for specific pathogens and defining generalizable approaches for related pathogens is a global priority and …
View article: The role of RhoA signaling pathways in regulating HIV-1 replication
The role of RhoA signaling pathways in regulating HIV-1 replication Open
RhoGTPases are involved in regulating important cellular processes including cytoskeletal organization, gene transcription and membrane vesicle transport – poising RhoGTPases to link these pathways to HIV-1 replication. However, RhoGTPase …
View article: Emerging Vaccine Technologies
Emerging Vaccine Technologies Open
Vaccination has proven to be an invaluable means of preventing infectious diseases by reducing both incidence of disease and mortality. However, vaccines have not been effectively developed for many diseases including HIV-1, hepatitis C vi…
View article: Proof of principle for epitope-focused vaccine design
Proof of principle for epitope-focused vaccine design Open
Reference EPFL-CONF-214089View record in Web of Science Record created on 2015-12-02, modified on 2017-05-10