Rebecca J. M. Goss
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View article: Precision Molecular Editing: Predicting Substrate Scope and Regiochemistry for CHEESY1, a Flavin Dependent Halogenase
Precision Molecular Editing: Predicting Substrate Scope and Regiochemistry for CHEESY1, a Flavin Dependent Halogenase Open
The ability to carry out C-H activation at any site on any heteroaromatic scaffold is a holy grail, offering the potential to revolutionize molecule making. Precision editing, activating, and replacing a C-H bond with a carbon halogen bond…
View article: Cycloadditions as a Sweet Route to ‘Double C-Glycosylation’
Cycloadditions as a Sweet Route to ‘Double C-Glycosylation’ Open
Pharmaceuticals, such as the antibiotic erythromycin, and sodium-dependent glucose transporter (SGLT1 & SGTL2) inhibitors such as Bexagliflozin (diabetes) and Sotagliflozin (heart disease), are often sugar-decorated (glycosylated). Glycosy…
View article: Isolation and Identification of Cis-2,5-Diketopiperazine from a Novel Bacillus Strain and Synthesis of Its Four Stereoisomers
Isolation and Identification of Cis-2,5-Diketopiperazine from a Novel Bacillus Strain and Synthesis of Its Four Stereoisomers Open
The Bacillus horneckiae-like strain 2011SOCCUF3 was isolated from the marine sponge Spongia officinalis and its metabolome was studied for secondary metabolites with antimicrobial activity. Culturing in the presence of Diaion HP-20 resin a…
View article: Compendium of Metabolomic and Genomic Datasets for Cyanobacteria: Mined the Gap
Compendium of Metabolomic and Genomic Datasets for Cyanobacteria: Mined the Gap Open
Cyanobacterial blooms, producing toxic secondary metabolites, are becoming increasingly common phenomena in the face of rising global temperatures. They are the world's most abundant photosynthetic organisms, largely owing their success to…
View article: The Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Antibiotic and Anticancer Agent Marinomycin
The Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Antibiotic and Anticancer Agent Marinomycin Open
With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene antibiotic from a marine microbe, has been shown capable of killing methicillin…
View article: Artificial intelligence for natural product drug discovery
Artificial intelligence for natural product drug discovery Open
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learn…
View article: The Impact of Viral Infection on the Chemistries of the Earth’s Most Abundant Photosynthesizes: Metabolically Talented Aquatic Cyanobacteria
The Impact of Viral Infection on the Chemistries of the Earth’s Most Abundant Photosynthesizes: Metabolically Talented Aquatic Cyanobacteria Open
Cyanobacteria are the most abundant photosynthesizers on earth, and as such, they play a central role in marine metabolite generation, ocean nutrient cycling, and the control of planetary oxygen generation. Cyanobacteriophage infection exe…
View article: Fully Aqueous and Air-Compatible Cross-Coupling of Primary Alkyl Halides with Aryl Boronic Species: A Possible and Facile Method
Fully Aqueous and Air-Compatible Cross-Coupling of Primary Alkyl Halides with Aryl Boronic Species: A Possible and Facile Method Open
Aqueous transformations confer many advantages, including decreased environmental impact and increased opportunity for biomolecule modulation. Although several studies have been conducted to enable the cross-coupling of aryl halides in aqu…
View article: Contents list
Contents list Open
Permissions Request permissions Contents list Chem. Soc. Rev., 2023, 52, 6225 DOI: 10.1039/D3CS90076B This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publi…
View article: GenoChemetic Strategy for Derivatization of the Violacein Natural Product Scaffold
GenoChemetic Strategy for Derivatization of the Violacein Natural Product Scaffold Open
Natural products and their analogues are often challenging to synthesize due to their complex scaffolds and embedded functional groups. Solely relying on engineering the biosynthesis of natural products may lead to limited compound diversi…
View article: An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals
An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals Open
Simple, aqueous and direct cross-coupling of diverse and complex (hetero)aromatic halides and active pharmaceutical agents.
View article: Antiviral drug discovery: preparing for the next pandemic
Antiviral drug discovery: preparing for the next pandemic Open
SARS-CoV-2, EBOV and emerging RNA viruses are amongst the most important global health threats; yet clinically approved antiviral drugs are available for only 10 of the more than 220 viruses known to infect humans.
View article: Correction: Antiviral drug discovery: preparing for the next pandemic
Correction: Antiviral drug discovery: preparing for the next pandemic Open
Correction for ‘Antiviral drug discovery: preparing for the next pandemic’ by Catherine S. Adamson et al. , Chem. Soc. Rev. , 2021, 50 , 3647–3655, DOI: 10.1039/D0CS01118E.
View article: Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation Open
An overview of enzymatic tools for generation of carbon–halogen bonds and their use in enabling selective C–H functionalisation through combination of enzyme and chemo catalysis.
View article: Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs
Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs Open
Plant secondary metabolites have applications for the food, biofuel, and pharmaceutical industries. Recent advances in pathway elucidation and host expression systems now allow metabolic engineering of plant metabolic pathways to produce “…
View article: SynBio‐SynChem Approaches to Diversifying the Pacidamycins through the Exploitation of an Observed Pictet‐Spengler Reaction
SynBio‐SynChem Approaches to Diversifying the Pacidamycins through the Exploitation of an Observed Pictet‐Spengler Reaction Open
A nonenzymatic Pictet‐Spengler reaction has been postulated to give rise to a subset of naturally occurring uridyl peptide antibiotics (UPAs). Here, using a combination of strain engineering and synthetic chemistry, we demonstrate that Pic…
View article: Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins
Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins Open
Our previous gel filtration of Pac13 suggested a monomer. [1]Analysis of the crystal structure was inconclusive. [1,2]Therefore based on the gel filtration analyses we concluded this protein to be a monomer in solution.Thanks to the letter…
View article: Phenylalanine <i>meta</i>‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation
Phenylalanine <i>meta</i>‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation Open
The rare nonproteinogenic amino acid, meta ‐ l ‐tyrosine is biosynthetically intriguing. Whilst the biogenesis of tyrosine from phenylalanine is well characterised, the mechanistic basis for meta ‐hydroxylation is unknown. Herein, we repor…
View article: Discovery pipelines for marine resources: an ocean of opportunity for biotechnology?
Discovery pipelines for marine resources: an ocean of opportunity for biotechnology? Open
Marine microbial diversity offers enormous potential for discovery of compounds of crucial importance in healthcare, food security and bioindustry. However, access to it has been hampered by the difficulty of accessing and growing the orga…
View article: Heck Diversification of Indole‐Based Substrates under Aqueous Conditions: From Indoles to Unprotected Halo‐tryptophans and Halo‐tryptophans in Natural Product Derivatives
Heck Diversification of Indole‐Based Substrates under Aqueous Conditions: From Indoles to Unprotected Halo‐tryptophans and Halo‐tryptophans in Natural Product Derivatives Open
The blending of synthetic chemistry with biosynthetic processes provides a powerful approach to synthesis. Biosynthetic halogenation and synthetic cross‐coupling have great potential to be used together, for small molecule generation, acce…
View article: Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions Open
Providing a tool to enhance natural product diversification, we report the first Buchwald Hartwig late stage modification in water of short peptides and the natural product barettin.
View article: A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A
A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A Open
Perfect partners for photoprotection: orally ingestible sporopollenin confers striking photoprotection to the powerful, polyene antibiotic, marinomycin A, as well as enabling its selective extraction.
View article: Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast <i>Rhodotorula kratochvilovae</i> LS11
Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast <i>Rhodotorula kratochvilovae</i> LS11 Open
Patulin (1) is a mycotoxin contaminant in fruit and vegetable products worldwide. Biocontrol agents, such as the yeast Rhodotorula kratochvilovae strain LS11, can reduce patulin (1) contamination in food. R. kratochvilovae LS11 converts pa…
View article: A GenoChemetic strategy for derivatization of the violacein natural product scaffold
A GenoChemetic strategy for derivatization of the violacein natural product scaffold Open
Natural products and their analogues are often challenging to synthesise due to their complex scaffolds and embedded functional groups. Solely relying on engineering the biosynthesis of natural products may lead to limited compound diversi…
View article: Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins
Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins Open
The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3′‐deoxyurid…
View article: Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins
Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins Open
The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3′‐deoxyurid…
View article: An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge <i>Theonella swinhoei</i> WA
An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge <i>Theonella swinhoei</i> WA Open
Uncultured bacteria from sponges have been demonstrated to be responsible for the generation of many potent, bioactive natural products including halogenated metabolites.1 The identification of gene clusters from the metagenomes of such ba…
View article: Mild, Aqueous α‐Arylation of Ketones: Towards New Diversification Tools for Halogenated Metabolites and Drug Molecules
Mild, Aqueous α‐Arylation of Ketones: Towards New Diversification Tools for Halogenated Metabolites and Drug Molecules Open
The palladium‐catalysed aqueous α‐arylation of ketones was developed and tested for a large variety of reaction partners. These mild conditions enabled the coupling of aryl/alkyl‐ketones with N‐protected halotryptophans, heterocyclic haloa…