Rebecca L. Cox
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View article: Intraosseous Bone Marrow Concentrate for Hip Osteoarthritis: A Case Series
Intraosseous Bone Marrow Concentrate for Hip Osteoarthritis: A Case Series Open
View article: The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit Open
A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintainin…
View article: The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit Open
A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintainin…
View article: The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit Open
A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintainin…
View article: Fmo induction as a tool to screen for pro-longevity drugs
Fmo induction as a tool to screen for pro-longevity drugs Open
View article: A diet of oxidative stress–adapted bacteria improves stress resistance and lifespan in <i>C. elegans</i> via p38-MAPK
A diet of oxidative stress–adapted bacteria improves stress resistance and lifespan in <i>C. elegans</i> via p38-MAPK Open
Organisms across taxa face stresses including variable temperature, redox imbalance, and xenobiotics. Successfully responding to stress and restoring homeostasis are crucial for survival. Aging is associated with a decreased stress respons…
View article: A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in<i>C. elegans</i>via p38-MAPK
A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in<i>C. elegans</i>via p38-MAPK Open
Organisms across taxa are exposed to stresses such as variable temperature, redox imbalance, and xenobiotics. Successfully responding to stress and restoring homeostasis is crucial for viability of the organism. During aging, the ability t…
View article: FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans
FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans Open
Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for metabolizing a wide range of exogenous compounds. In C. elegans , fmo-2 expression increases lifespan and healthspan downstream of multiple longevity-promoting pathw…
View article: FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism
FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism Open
Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for metabolizing a wide range of exogenous compounds. In C. elegans , fmo-2 expression increases lifespan and healthspan downstream of multiple longevity-promoting pathw…
View article: Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus
Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus Open
Retromer has emerged as a master conductor of endosomal trafficking, and VPS35 and other retromer-related proteins are found to be deficient in late-onset Alzheimer’s disease (AD). Depleting VPS35 in neurons impairs retromer function, affe…
View article: Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain
Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain Open
Tuberous sclerosis complex (TSC) is an autosomal dominant neurogenetic disorder affecting the brain and other vital organs. Neurological symptoms include epilepsy, intellectual disability, and autism. TSC is caused by a loss-of-function mu…
View article: Rationally designed PPARδ-specific agonists and their therapeutic potential for metabolic syndrome
Rationally designed PPARδ-specific agonists and their therapeutic potential for metabolic syndrome Open
The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors regulates a wide variety of lipid-related genes, including those responsible for adipose differentiation, cholesterol metabolism, and lipid metabolism and tr…