Rebecca Lillis
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View article: Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location
Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location Open
Sexually transmitted infections, e.g., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG), present with similar signs/symptoms and are often treated empirically due to delays in receiving diagnostic test…
View article: A-283 Performance of a Research-Use-Only Prototype of a Highly Multiplexed Sample-to-Answer Diagnostic System for Identification of Vaginal Infections from Vaginal Swabs
A-283 Performance of a Research-Use-Only Prototype of a Highly Multiplexed Sample-to-Answer Diagnostic System for Identification of Vaginal Infections from Vaginal Swabs Open
Background Bacterial vaginosis (BV, defined as dysbiosis of the vaginal microbiome), vulvovaginal candidiasis (VVC, caused by Candida species), and trichomoniasis, caused by Trichomonas vaginalis, are highly prevalent, symptomatically simi…
View article: LSU-CrescentCare Sexual Health Center: An inter-organizational partnership initiative to improve access to sexual health services in New Orleans, Louisiana, United States
LSU-CrescentCare Sexual Health Center: An inter-organizational partnership initiative to improve access to sexual health services in New Orleans, Louisiana, United States Open
Objectives: To describe a partnership between CrescentCare and Louisiana State University (LSU) School of Medicine that created a new Sexual Health Clinic in New Orleans, and to assess the health services that patients sought and re…
View article: Evaluation of the user experience for a point of care molecular test for causes of vaginitis
Evaluation of the user experience for a point of care molecular test for causes of vaginitis Open
Background Vaginitis is a major cause of healthcare visits in the US, costing over $1.2 billion annually. Point-of-care (POC) nucleic acid amplification tests (NAATs) could improve accuracy of diagnosis and treatment during initial visit f…
View article: Prevalence and Accuracy of Empiric Treatment Among Patients With Vaginitis Symptoms in the United States
Prevalence and Accuracy of Empiric Treatment Among Patients With Vaginitis Symptoms in the United States Open
Background Evidence suggests low diagnostic test utilization and high empiric prescribing rates for vaginitis symptoms. This study retrospectively assessed real-world bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoni…
View article: Real-world clinical burden of patients presenting with vaginitis symptoms in the United States
Real-world clinical burden of patients presenting with vaginitis symptoms in the United States Open
View article: Identifying Implementation Strategies to Enhance HIV Pre-Exposure Prophylaxis Uptake Among Black Cisgender Women in New Orleans, Louisiana
Identifying Implementation Strategies to Enhance HIV Pre-Exposure Prophylaxis Uptake Among Black Cisgender Women in New Orleans, Louisiana Open
There is an unmet need for HIV prevention among Black cisgender women. From January to November 2020, we conducted formative research to develop locally informed implementation strategies to enhance pre-exposure prophylaxis (PrEP) uptake a…
View article: Randomized Multicenter Trial for the Validation of an Easy-to-Administer Algorithm to Define Penicillin Allergy Status in Sexually Transmitted Infection Clinic Outpatients
Randomized Multicenter Trial for the Validation of an Easy-to-Administer Algorithm to Define Penicillin Allergy Status in Sexually Transmitted Infection Clinic Outpatients Open
Background Approximately 15% of patients in sexually transmitted infection (STI) clinics report penicillin allergies, complicating treatment for syphilis and gonorrhea. Nonetheless, >90% do not have a penicillin allergy when evaluated. …
View article: Unpasteurized cheese: milking a case of neurobrucellosis
Unpasteurized cheese: milking a case of neurobrucellosis Open
View article: Client Perspectives on the Development of a Rapid PrEP Initiative at a Sexual Health Center in New Orleans, Louisiana
Client Perspectives on the Development of a Rapid PrEP Initiative at a Sexual Health Center in New Orleans, Louisiana Open
Uptake of PrEP remains suboptimal, especially in the Southern United States. Same-day or “Rapid PrEP Initiatives” (RPIs) in sexual health centers (SHCs) could facilitate access and overcome barriers to PrEP. We studied the adaptation of an…
View article: Association of Chlamydia trachomatis burden with the vaginal microbiota, bacterial vaginosis, and metronidazole treatment
Association of Chlamydia trachomatis burden with the vaginal microbiota, bacterial vaginosis, and metronidazole treatment Open
Bacterial vaginosis (BV), a dysbiosis of the vaginal microbiota, is a common coinfection with Chlamydia trachomatis (Ct), and BV-associated bacteria (BVAB) and their products have been implicated in aiding Ct evade natural immunity. Here, …
View article: Outpatient sexually transmitted infection testing and treatment patterns in the United States: a real-world database study
Outpatient sexually transmitted infection testing and treatment patterns in the United States: a real-world database study Open
View article: Characteristics of Mpox Infections in Louisiana in the 2022 Outbreak
Characteristics of Mpox Infections in Louisiana in the 2022 Outbreak Open
The 2022 outbreak of mpox in Louisiana was limited to just >300 cases, perhaps an unexpected outcome given the state's high rates of HIV and other sexually transmitted infections (STIs). We aimed to describe the local outbreak within two h…
View article: A novel Gardnerella, Prevotella, and Lactobacillus standard that improves accuracy in quantifying bacterial burden in vaginal microbial communities
A novel Gardnerella, Prevotella, and Lactobacillus standard that improves accuracy in quantifying bacterial burden in vaginal microbial communities Open
Bacterial vaginosis (BV) is the most common vaginal dysbiosis. In this condition, a polymicrobial biofilm develops on vaginal epithelial cells. Accurately quantifying the bacterial burden of the BV biofilm is necessary to further our under…
View article: Clinical Evaluation of a New Molecular Test for the Detection of Organisms Causing Vaginitis and Vaginosis
Clinical Evaluation of a New Molecular Test for the Detection of Organisms Causing Vaginitis and Vaginosis Open
In this prospective, observational, method comparison clinical study, the Xpert Xpress MVP test (MVP) was evaluated using both clinician-collected (CVS) and self-collected vaginal swabs (SVS) collected in a clinical setting. The study was …
View article: Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization
Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization Open
The endocervix, the primary site of Chlamydia trachomatis (Ct) infection in women, has a unique repertoire of locally synthesized IgG and secretory IgA (SIgA) with contributions from serum IgG. Here, we assessed the ability of genital and …
View article: Evaluation of an HIV Pre-Exposure Prophylaxis Referral System: From Sexual Health Center to Federally Qualified Health Center Pre-Exposure Prophylaxis Clinic
Evaluation of an HIV Pre-Exposure Prophylaxis Referral System: From Sexual Health Center to Federally Qualified Health Center Pre-Exposure Prophylaxis Clinic Open
Innovative delivery strategies are needed to facilitate access to HIV pre-exposure prophylaxis (PrEP). The objective of this study was to evaluate a navigator-facilitated PrEP referral process from a sexual health center (SHC) to a co-loca…
View article: Differences in the Genital Microbiota in Women Who Naturally Clear Chlamydia trachomatis Infection Compared to Women Who Do Not Clear; A Pilot Study
Differences in the Genital Microbiota in Women Who Naturally Clear Chlamydia trachomatis Infection Compared to Women Who Do Not Clear; A Pilot Study Open
In vitro studies indicate IFNγ is central to Chlamydia trachomatis (Ct) eradication, but its function may be compromised by anaerobes typically associated with bacterial vaginosis (BV), a frequent co-morbidity in women with Ct. Here we inv…
View article: Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization
Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization Open
The endocervix, the primary site of Chlamydia trachomatis (Ct) infection in women, has a unique repertoire of locally synthesized IgG and secretory IgA (SIgA) with contributions from serum IgG. Here, we assessed the ability of genital and …
View article: Osteoarticular tuberculosis involving the elbow
Osteoarticular tuberculosis involving the elbow Open
View article: 104. Evaluation of a Prep Referral System: From Sexual Health Center to Federally Qualified Health Center Prep Clinic
104. Evaluation of a Prep Referral System: From Sexual Health Center to Federally Qualified Health Center Prep Clinic Open
Background In the United States, less than one-quarter of those who are eligible for pre-exposure prophylaxis (PrEP) have been prescribed the medication. Innovative strategies of PrEP delivery are needed to facilitate access and overcome b…
View article: Characteristics of Mycoplasma genitalium Urogenital Infections in a Diverse Patient Sample from the United States: Results from the Aptima Mycoplasma genitalium Evaluation Study (AMES)
Characteristics of Mycoplasma genitalium Urogenital Infections in a Diverse Patient Sample from the United States: Results from the Aptima Mycoplasma genitalium Evaluation Study (AMES) Open
Data from a large prospective multicenter clinical validation study of a nucleic acid amplification in vitro diagnostic test for Mycoplasma genitalium were analyzed to describe the prevalence of M. genitalium infection, risk factors, and d…
View article: Molecular Testing for Mycoplasma genitalium in the United States: Results from the AMES Prospective Multicenter Clinical Study
Molecular Testing for Mycoplasma genitalium in the United States: Results from the AMES Prospective Multicenter Clinical Study Open
A prospective multicenter clinical study involving subjects from 21 sites across the United States was conducted to validate the performance of a new in vitro diagnostic nucleic acid amplification test (NAAT) for the detection of Mycoplasm…
View article: P790 Determining the origins of repeat<i>trichomonas vaginalis</i>infections using clinical versus genotype-informed criteria
P790 Determining the origins of repeat<i>trichomonas vaginalis</i>infections using clinical versus genotype-informed criteria Open
Background High rates of repeat T. vaginalis infections post-treatment have been reported. It is essential to understand the origin of these infections (i.e. treatment failure or reinfection) to determine the best secondary preventi…
View article: An Unusual Case of Acute Abdomen: Intestinal Ascariasis: Case Report and Literature Review
An Unusual Case of Acute Abdomen: Intestinal Ascariasis: Case Report and Literature Review Open
Ascariasis is uncommon in United States of America but can be seen in immigrants and travelers. It can present with intestinal complications. We present a case of acute suppurative appendicitis with bowel perforation. Interestingly and une…
View article: Optimal Timing for Trichomonas vaginalis Test of Cure Using Nucleic Acid Amplification Testing
Optimal Timing for Trichomonas vaginalis Test of Cure Using Nucleic Acid Amplification Testing Open
Background The optimal timing for nucleic acid amplification testing (NAAT) posttreatment for Trichomonas vaginalis has not been fully established. Testing too soon posttreatment may detect remnant nucleic acid that is not from viable orga…
View article: Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial
Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial Open
View article: Detection of<i>Chlamydia trachomatis</i>and<i>Neisseria gonorrhoeae</i>with the cobas CT/NG v2.0 test: performance compared with the BD ProbeTec CT Q<sup>x</sup>and GC Q<sup>x</sup>amplified DNA and Aptima AC2 assays
Detection of<i>Chlamydia trachomatis</i>and<i>Neisseria gonorrhoeae</i>with the cobas CT/NG v2.0 test: performance compared with the BD ProbeTec CT Q<sup>x</sup>and GC Q<sup>x</sup>amplified DNA and Aptima AC2 assays Open
Objectives Infections due to Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are among the most common bacterial sexually transmitted infections worldwide, most of which are asymptomatic. Detection of infection using a variety of…
View article: A novel whole-bacterial enzyme linked-immunosorbant assay to quantify Chlamydia trachomatis specific antibodies reveals distinct differences between systemic and genital compartments
A novel whole-bacterial enzyme linked-immunosorbant assay to quantify Chlamydia trachomatis specific antibodies reveals distinct differences between systemic and genital compartments Open
Chlamydia trachomatis (CT) is the leading sexually transmitted bacterial infection. The continued global burden of CT infection strongly predicates the need for a vaccine to supplement current chlamydial control programs. The correlates of…
View article: O01.5 Origin and predictors of early repeat infections among hiv negative women with<i>trichomonas vaginalis</i>receiving a 2 g dose of metronidazole
O01.5 Origin and predictors of early repeat infections among hiv negative women with<i>trichomonas vaginalis</i>receiving a 2 g dose of metronidazole Open
Introduction A recent meta-analysis demonstrated superiority of multi-dose metronidazole (MTZ) over the CDC and WHO recommended 2 g dose for the treatment of T. vaginalis (TV). Another study among HIV+ women with TV found higher test-of-cu…