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View article: Cardiac involvement in established idiopathic inflammatory myopathy assessed by cardiac magnetic resonance mapping
Cardiac involvement in established idiopathic inflammatory myopathy assessed by cardiac magnetic resonance mapping Open
Objectives To investigate the prevalence of subclinical, myocardial involvement in patients with established idiopathic inflammatory myopathies (IIM) compared to healthy controls using T1 and T2 mapping by cardiac magnetic resonance imagin…
View article: Interleukin-6 receptor antibodies (tocilizumab) in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (DOBERMANN-T): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial
Interleukin-6 receptor antibodies (tocilizumab) in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (DOBERMANN-T): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial Open
Background Inflammation and neurohormonal activation play a significant role in the adverse outcome seen in acute myocardial infarction (AMI) and the development of cardiogenic shock (CS), which is associated with a mortality rate up to 50…
View article: Low-dose dobutamine in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (the DOBERMANN-D trial): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial
Low-dose dobutamine in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (the DOBERMANN-D trial): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial Open
Background Cardiogenic shock (CS) occurs in 5–10% of patients with acute myocardial infarction (AMI), and the condition is associated with a 30-day mortality rate of up to 50%. Most of the AMI patients are in SCAI SHOCK stage B upon hospit…
View article: Multimodality Imaging Uncovers Giant Coronary Artery Aneurysm Mimicking Cardiac Tumor
Multimodality Imaging Uncovers Giant Coronary Artery Aneurysm Mimicking Cardiac Tumor Open
BACKGROUND Giant coronary artery aneurysms (CAA) are extremely rare and can mimic cardiac tumors. Therefore, an unidentified mass in the heart requires a multimodality imaging approach for accurate diagnosis and guidance of further managem…
View article: Sex-and age-related variations in myocardial tissue composition of the healthy heart: a native T1 mapping cohort study
Sex-and age-related variations in myocardial tissue composition of the healthy heart: a native T1 mapping cohort study Open
Aims Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literat…
View article: Myocardial salvage and infarct characteristics in patients with ST-elevation myocardial infarction classified by ORBI risk score
Myocardial salvage and infarct characteristics in patients with ST-elevation myocardial infarction classified by ORBI risk score Open
Background The Observatoire Régional Breton sur l'Infarctus (ORBI) [1] risk score was developed to predict in-hospital cardiogenic shock (CS) development in patients with ST elevation myocardial infarction (STEMI) treated with primary perc…
View article: Myocardial fibrosis associates with lupus anticoagulant in patients with systemic lupus erythematosus
Myocardial fibrosis associates with lupus anticoagulant in patients with systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that carries increased risk of cardiovascular disease; however, the underlying pathophysiological mechanisms remain poorly understood. We aimed to investigate the prevalenc…
View article: Low-dose dobutamine infusion and single-dose tocilizumab in acute myocardial infarction patients with high risk of cardiogenic shock development - rationale and design of the DOBERMANN trial
Low-dose dobutamine infusion and single-dose tocilizumab in acute myocardial infarction patients with high risk of cardiogenic shock development - rationale and design of the DOBERMANN trial Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Novo Nordisk Fonden Background Cardiogenic shock (CS) is seen in up to 10% of patients with ST-elevation myocardial infarction (STEMI) and is associated …
View article: The COVID-19 in athletes (COVA) study: a national study on cardio-pulmonary involvement of SARS-CoV-2 infection among elite athletes
The COVID-19 in athletes (COVA) study: a national study on cardio-pulmonary involvement of SARS-CoV-2 infection among elite athletes Open
These clinically-driven data show no signs of cardiac involvement among athletes who tested positive for SARS-CoV-2 infection without cardiopulmonary symptoms and duration <7 days. Athletes with cardiopulmonary symptoms or prolonged durati…
View article: Left ventricular size and function in patients with systemic lupus erythematosus associate with lupus anticoagulant: An echocardiographic follow-up study
Left ventricular size and function in patients with systemic lupus erythematosus associate with lupus anticoagulant: An echocardiographic follow-up study Open
Presence of LAC was associated with measures of diastolic function as well as progressive LV dilatation during the 5-year follow-up. Thus, LAC might be a predictor of cardiac dysfunction in SLE patients. LAC is known to have implications f…
View article: Lupus anticoagulant in patients with systemic lupus erythematosus is associated with lower E/A ratio and progressive left ventricular dilatation: a five-year follow-up study
Lupus anticoagulant in patients with systemic lupus erythematosus is associated with lower E/A ratio and progressive left ventricular dilatation: a five-year follow-up study Open
Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Copenhagen University Hospital Background Systemic lupus erythematosus (SLE) is an autoimmune disease with increased risk of cardiovascular compl…
View article: Myositis-specific autoantibodies and QTc changes by ECG in idiopathic inflammatory myopathies
Myositis-specific autoantibodies and QTc changes by ECG in idiopathic inflammatory myopathies Open
Objectives The aim of this study was to investigate cardiac involvement detected by ECG in patients with idiopathic inflammatory myopathies (IIMs) and to evaluate possible associations between the autoantibody profile and ECG changes in th…
View article: Cardiac arrest in anti-mitochondrial antibody associated inflammatory myopathy
Cardiac arrest in anti-mitochondrial antibody associated inflammatory myopathy Open
Insight into predictors of cardiac involvement in inflammatory myopathies is sparse. A negative prognostic role of anti-mitochondrial antibodies (AMA) has been noticed and is supported by the current case. We describe a male patient who at…
View article: Association between left ventricular diastolic function and right ventricular function and morphology in asymptomatic aortic stenosis
Association between left ventricular diastolic function and right ventricular function and morphology in asymptomatic aortic stenosis Open
Moderate diastolic dysfunction is associated with increased RV afterload (elastance), which is compensated at rest, but is associated with increased RAP and inversely related to maximal oxygen consumption during maximal exercise.
View article: End-systolic wall stress in aortic stenosis: comparing symptomatic and asymptomatic patients
End-systolic wall stress in aortic stenosis: comparing symptomatic and asymptomatic patients Open
Aims In aortic stenosis (AS), there is poor association between symptoms and conventional markers of AS severity or left ventricular (LV) systolic function. This may reflect that symptoms arise from LV diastolic dysfunction or that aortic …
View article: Postoperative atrial fibrillation after aortic valve replacement is a risk factor for long-term atrial fibrillation
Postoperative atrial fibrillation after aortic valve replacement is a risk factor for long-term atrial fibrillation Open
OBJECTIVES Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. However, knowledge on the rate of long-term atrial fibrillation (LTAF) after POAF remains unclear. We investigated predictors of POAF i…
View article: Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation
Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation Open
Objective To assess the association between cardiac morphology and function assessed with cardiac MRI (CMRI) and haemodynamics at rest and during exercise in patients with primary mitral regurgitation (MR). Methods In an observational stud…
View article: Postoperative Reverse Remodeling and Symptomatic Improvement in Normal-Flow Low-Gradient Aortic Stenosis After Aortic Valve Replacement
Postoperative Reverse Remodeling and Symptomatic Improvement in Normal-Flow Low-Gradient Aortic Stenosis After Aortic Valve Replacement Open
Background— Severe aortic stenosis (AS) most often presents with reduced aortic valve area (<1 cm 2 ), normal stroke volume index (≥35 mL/m 2 ), and either high mean gradient (≥40 mm Hg; normal-flow high-gradient AS) or low mean gradient (…
View article: P1639Association between left ventricular diastolic function and RV function and morphology in asymptomatic aortic stenosis at rest and during exercise
P1639Association between left ventricular diastolic function and RV function and morphology in asymptomatic aortic stenosis at rest and during exercise Open
cardiac in 77% of LF/LG patients (90/117) and 70% of those with NF/LG (47/67); P=0.02.No clinical strokes or TIA were observed in the 30 days after procedure in any of the patients.Conclusions: Invasive hemodynamic assessment of AS utilizi…