Reem Shalabi
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View article: Pediatric Case of Acute Epiglottitis due to Staphylococcus aureus
Pediatric Case of Acute Epiglottitis due to Staphylococcus aureus Open
Epiglottitis is an inflammatory condition of the epiglottis and its nearby structures, and leads to fever, drooling, and sore throat. This potentially fatal disease can progress to airway obstruction and requires emergency intervention. Ha…
View article: Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults
Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults Open
Background/Objectives: Obesity and type 2 diabetes (T2D) are associated with significant alterations in various metabolic biomarkers. Isthmin-1 (Ism1) has recently emerged as a potential marker of metabolic health and was shown in animal s…
View article: Durable remission of refractory and advanced stage mycosis fungoides/sezary syndrome utilizing an “outpatient” alemtuzumab, fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation
Durable remission of refractory and advanced stage mycosis fungoides/sezary syndrome utilizing an “outpatient” alemtuzumab, fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation Open
View article: Haematopoietic stem cell transplant patients have a high initial failure rate to hepatitis B vaccination that can be overcome with subsequent vaccination series
Haematopoietic stem cell transplant patients have a high initial failure rate to hepatitis B vaccination that can be overcome with subsequent vaccination series Open
Recipient immunity is compromised following allogeneic haematopoietic stem cell transplantation (HSCT), necessitating prophylaxis with antimicrobial and antiviral agents and re-immunisation against viral and bacterial pathogens.1 Most pati…
View article: A pilot trial of complement inhibition using eculizumab to overcome platelet transfusion refractoriness in human leukocyte antigen allo‐immunized patients
A pilot trial of complement inhibition using eculizumab to overcome platelet transfusion refractoriness in human leukocyte antigen allo‐immunized patients Open
Summary Heavily transfused patients frequently develop human leukocyte antigen (HLA) allo‐immunization resulting in platelet transfusion refractoriness and a high risk for life‐threatening thrombocytopenia. Data suggest complement activati…
View article: Ex Vivo Nicotinamide-Expanded (NAM-Expanded) Unrelated Cord Bloodtransplantation (UCB) for Refractory Severe Aplastic Anemia Results in Rapid Engraftment and Expedites Immune Recovery
Ex Vivo Nicotinamide-Expanded (NAM-Expanded) Unrelated Cord Bloodtransplantation (UCB) for Refractory Severe Aplastic Anemia Results in Rapid Engraftment and Expedites Immune Recovery Open
IntroductionAllogeneic hematopoietic stem cell transplantation using UCB (UCBT) is an alternative approach for severe aplastic anemia (SAA) patients (pts) lacking an HLA matched donor. However, UCBT is associated with delayed engraftment, …
View article: Alopecia Universalis and Chronic Graft-vs-Host Disease Treated With Ruxolitinib
Alopecia Universalis and Chronic Graft-vs-Host Disease Treated With Ruxolitinib Open
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View article: A phase I study of HERV-E TCR transduced autologous T Cells (HERV-E TCR T Cells) in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC)
A phase I study of HERV-E TCR transduced autologous T Cells (HERV-E TCR T Cells) in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) Open
Background: Our team isolated cytotoxic T lymphocyte (CTL) lines from a patient who had sustained mccRCC regression after an allogeneic transplant that showed specific killing of ccRCC. Utilizing these CTL and cDNA expression cloning, we d…
View article: Allogeneic transplantation using <scp>CD</scp>34<sup>+</sup> selected peripheral blood progenitor cells combined with non‐mobilized donor T cells for refractory severe aplastic anaemia
Allogeneic transplantation using <span>CD</span>34<sup>+</sup> selected peripheral blood progenitor cells combined with non‐mobilized donor T cells for refractory severe aplastic anaemia Open
Summary Allogeneic haematopoietic stem cell transplantation is curative for severe aplastic anaemia ( SAA ) unresponsive to immunosuppressive therapy. To reduce chronic graft‐ versus ‐host disease ( GVHD ), which occurs more frequently aft…
View article: Tumor regression concomitant with steroid-refractory GvHD highlights the pitfalls of PD-1 blockade following allogeneic hematopoietic stem cell transplantation
Tumor regression concomitant with steroid-refractory GvHD highlights the pitfalls of PD-1 blockade following allogeneic hematopoietic stem cell transplantation Open