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View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
View article: Equitable Collaboration Between <scp>LMIC</scp> and <scp>HIC</scp> Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research
Equitable Collaboration Between <span>LMIC</span> and <span>HIC</span> Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research Open
International collaborations between high‐income countries (HICs) and low‐ and middle‐income countries (LMICs) have become increasingly essential in advancing global health, particularly within psychiatric research. These partnerships not …
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from th…
View article: The Psychiatric Genomics Consortium: Discoveries and Directions
The Psychiatric Genomics Consortium: Discoveries and Directions Open
The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to 13 psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from the …
View article: Deciphering how ApoE shapes neurodevelopment
Deciphering how ApoE shapes neurodevelopment Open
Background What does neurodevelopment look like when neurodegeneration is the outcome – this is overarching theme of investigations currently ongoing in our lab. The E4 isoform of ApoE protein is the most consistently replicated risk facto…
View article: Equitable Collaboration between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research
Equitable Collaboration between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research Open
International collaborations between high-income countries (HICs) and low- and middle-income countries (LMICs) have become increasingly essential in advancing global health, particularly within psychiatric research. These partnerships not …
View article: Equitable Collaboration between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research
Equitable Collaboration between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research Open
International collaborations between high-income countries (HICs) and low- and middle-income countries (LMICs) have become increasingly essential in advancing global health, particularly within psychiatric research. These partnerships not …
View article: A cross ancestry genetic study of psychiatric disorders from India
A cross ancestry genetic study of psychiatric disorders from India Open
Genome-wide association studies across diverse populations may help validate and confirm genetic contributions to risk of disease. We estimated the extent of population stratification as well as the predictive accuracy of polygenic scores …
View article: Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder Open
Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental aberrations, particularly in familial BD, which may include causative genetic variants. In the present study, we derived cortical organoids from BD pa…
View article: Editorial: Reproducibility in neuroscience
Editorial: Reproducibility in neuroscience Open
Scientific progress depends on the ability to independently repeat and validate key scientific findings. To verify the rigor, robustness, and validity of a research study, scientists test if they can reach the same conclusions when they us…
View article: Proteomic analysis reveals APOE isoform-specific regulation of ribosomes in neural precursor cells
Proteomic analysis reveals APOE isoform-specific regulation of ribosomes in neural precursor cells Open
ApoE4 isoform contributes to increased risk for Alzheimer’s Disease (AD) over the life course of individuals. Much remains unknown about the biological pathways that connect APOE4 genotype with the development of pathology that eventually …
View article: A replication study on key neurodevelopmental pathways affected by valproate treatment of neural precursor cells
A replication study on key neurodevelopmental pathways affected by valproate treatment of neural precursor cells Open
Adults with bipolar disorder or epileptic seizures are commonly prescribed sodium valproate. In utero exposure to this drug is linked to a multitude of defects in normal brain development, from neural tube defects to autism spectrum disord…
View article: Abnormalities in the migration of neural precursor cells in familial bipolar disorder
Abnormalities in the migration of neural precursor cells in familial bipolar disorder Open
Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of a functional brain. We studied the migration patterns of induced pluripotent stem cell-de…
View article: Indian scientists tackle the infodemic
Indian scientists tackle the infodemic Open
View article: Abnormalities in migration of neural precursor cells in familial bipolar disorder
Abnormalities in migration of neural precursor cells in familial bipolar disorder Open
Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of a functional brain. We studied the migration patterns of induced pluripotent stem cell (I…
View article: Targeted Sequencing Detects Variants That May Contribute to the Risk of Neuropsychiatric Disorders
Targeted Sequencing Detects Variants That May Contribute to the Risk of Neuropsychiatric Disorders Open
View article: An audit and insights from clinical exome sequencing in psychiatry: genotype-phenotype correlation
An audit and insights from clinical exome sequencing in psychiatry: genotype-phenotype correlation Open
BACKGROUND:Psychiatric syndromes have polymorphic symptomatology, and are known to be heritable. Psychiatric symptoms (and even syndromes) often occur as part of the clinical presentation in rare Mendelian syndromes. Clinical exome sequenc…
View article: Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines
Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines Open
Lithium is an effective, well-established treatment for bipolar disorder (BD). However, the mechanisms of its action, and reasons for variations in clinical response, are unclear. We used neural precursor cells (NPCs) and lymphoblastoid ce…
View article: Cell cycle abnormality is a cellular phenotype in OCD
Cell cycle abnormality is a cellular phenotype in OCD Open
Abnormal indices of cell cycle regulation have been reported in multiple psychiatric disorders. Though reports specific to obsessive compulsive disorder (OCD) are scant, numerous studies have highlighted partly common underlying biology in…
View article: Association of <i>SAPAP3</i> allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder
Association of <i>SAPAP3</i> allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder Open
Background Though several SAPAP3 gene knockout studies in mice have implicated its role in compulsivity, human studies have failed to demonstrate its association with obsessive-compulsive disorder (OCD). We examined the association between…
View article: Studying cellular functions in bipolar disorder: Are there specific predictors of lithium response?
Studying cellular functions in bipolar disorder: Are there specific predictors of lithium response? Open
Background Lithium is the first-line mood stabilizer for the treatment of bipolar disorder (BD). In order to interrogate cellular phenotypes related to disease and lithium treatment response, this study used neural precursor cells (NPCs) a…