Regina B. Troyanovsky
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View article: Two δ-Catenins, Plakophilin 4 and p120, Promote Formation of Distinct Types of Adherens Junctions
Two δ-Catenins, Plakophilin 4 and p120, Promote Formation of Distinct Types of Adherens Junctions Open
Classic cadherins are instrumental for joining cells into tissues by producing cell-cell adhesions known as adherens junctions (AJs). These morphologically diverse structures are tailored to the specific cell sites, type of cells, and part…
View article: Actin-dependent α-catenin oligomerization contributes to adherens junction assembly
Actin-dependent α-catenin oligomerization contributes to adherens junction assembly Open
Classic cadherins, specifically E-cadherin in most epithelial cells, are transmembrane adhesion receptors, whose intracellular region interacts with proteins, termed catenins, forming the cadherin-catenin complex (CCC). The cadherin ectodo…
View article: Characterization of early and late events of adherens junction assembly
Characterization of early and late events of adherens junction assembly Open
Cadherins are transmembrane adhesion receptors. Cadherin ectodomains form adhesive 2D clusters through cooperative trans and cis interactions, whereas its intracellular region interacts with specific cytosolic proteins, termed catenins, to…
View article: Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin
Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin Open
Plakophilin-3 is a ubiquitously expressed protein found widely in epithelial cells and is a critical component of desmosomes. The plakophilin-3 carboxy-terminal domain harbors nine armadillo repeat motifs with largely unknown functions. He…
View article: Sorting of cadherin–catenin-associated proteins into individual clusters
Sorting of cadherin–catenin-associated proteins into individual clusters Open
Significance Cadherin–catenin complexes (CCCs) are a central component of adherens junctions. To produce an adhesive cell–cell contact, the CCC forms clusters, “E clusters,” driven by cooperative cis and trans interactions in the cadherin …
View article: Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex
Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex Open
The results show that spatial localization of desmosomes in polarized epithelial cells is jointly regulated by polarity protein Par3 and desmosomal protein Pkp3. This process is apparently based on the Par3-dependent interplay between two …
View article: <i>Trans</i>-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells
<i>Trans</i>-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells Open
Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a trans-endocytosis process. We find that internalized nectin-1–nectin-4 complexes follo…
View article: Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex
Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex Open
The basolateral protein Scribble (Scrib), a member of the LAP protein family, is essential for epithelial apicobasal polarity (ABP) in Drosophila. However, a conserved function for this protein in mammals is unclear. Here we show that the …
View article: Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior Open
Type II cadherins are cell-cell adhesion proteins critical for tissue patterning and neuronal targeting but whose molecular binding code remains poorly understood. Here, we delineate binding preferences for type II cadherin cell-adhesive r…
View article: Spatial and temporal organization of cadherin in punctate adherens junctions
Spatial and temporal organization of cadherin in punctate adherens junctions Open
Significance Adherens junctions (AJs) are major intercellular adhesive structures in vertebrates. Despite the critical role of AJs in tissue integrity and morphogenesis, the detailed organization of their key protein E-cadherin, inside and…