Regina Ebert
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View article: The underestimated burden of postoperative pulmonary complications in emergency laparotomy: a propensity score-matched analysis
The underestimated burden of postoperative pulmonary complications in emergency laparotomy: a propensity score-matched analysis Open
Introduction Emergency laparotomy (EL) remains one of the highest-risk procedures in general surgery, characterized by substantial postoperative morbidity and mortality. Despite major advances in perioperative medicine, current enhanced-re…
View article: Cu‐doped magnesium phosphate supraparticles: A promising material for bone tissue regeneration
Cu‐doped magnesium phosphate supraparticles: A promising material for bone tissue regeneration Open
Calcium phosphate (CaP) minerals have been widely studied as bone substitutes due to their excellent osteoconductivity and biocompatibility. However, their limited biodegradability remains a challenge. Magnesium phosphates (MgPs) are promi…
View article: A fully human In-vitro model for bone metastasis: potential of an electrospun scaffold as alternative to biological materials for osteoblast/osteoclast differentiation
A fully human In-vitro model for bone metastasis: potential of an electrospun scaffold as alternative to biological materials for osteoblast/osteoclast differentiation Open
The development of bone metastases poses a clinical challenge for patients with malignancies originating from diverse organs, including lungs, prostate, and breast. These metastatic events correlate with a poorer prognosis, and treatments …
View article: Assessment of the viability and mechanoresponsiveness of hMSC-TERT printed with bioinert, thermoresponsive hydrogels
Assessment of the viability and mechanoresponsiveness of hMSC-TERT printed with bioinert, thermoresponsive hydrogels Open
During three-dimensional (3D) bioprinting, the integration of living cells into hydrogel matrices results in complex biophysicochemical interactions between viscosity, shear stress, and temperature, critically influencing the structural an…
View article: Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues
Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues Open
Tumor cells are decorated with aberrant glycan structures on cell surfaces. It is well known that the glycocalyx serves as a main cellular regulator, although its role in cancer is still not completely understood. Over recent decades, seve…
View article: Peripheral blood cells enriched by adhesion to CYR61 are heterogenous myeloid modulators of tissue regeneration with early endothelial progenitor characteristics
Peripheral blood cells enriched by adhesion to CYR61 are heterogenous myeloid modulators of tissue regeneration with early endothelial progenitor characteristics Open
Introduction: Circulating precursor cell populations of various lineages have been identified with putative functions in tissue regeneration, which may have potential for cell based individual regenerative strategies. We previously demonst…
View article: FIGURE 5 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 5 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Functional analysis of MSC-interacting subpopulations (A–C): Functional enrichment analysis of differentially expressed genes (from RNA-seq) using Metascape. A, Gene ontology (GO) cluster analysis of gene lists that are unique for MA (left…
View article: FIGURE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
INA-6 growth conformations and survival on hMSCs. A, Interaction of INA-6 (green) with hMSCs (black, negative staining) at different INA-6 densities (constant hMSC densities). Scale bar = 200 µm. B, Frequency of single hMSCs (same as B) th…
View article: Supplementary Figures 1-8 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Figures 1-8 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Figure 1. Principle and quantification of the V-well adhesion assay of fluorescently labeled myeloma cells adapted by Weetall et al. 2001.Supplementary Figure 2. Validation of image cytometric analysis of cell cycle in four I…
View article: Data from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Data from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Multiple myeloma involves early dissemination of malignant plasma cells across the bone marrow; however, the initial steps of dissemination remain unclear. Human bone marrow–derived mesenchymal stromal cells (hMSC) stimulate myeloma cell e…
View article: Supplementary Methods from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Methods from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Methods
View article: Supplementary Table 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Table 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Table 2
View article: TABLE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
TABLE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Adhesion and ECM genes (shown in Fig. 6A) were filtered by their association with patient survival (P-adj. < 0.01) and were categorized as continuously downregulated during disease progression
View article: FIGURE 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Detachment of INA-6 daughter cells after cell division. A–D, INA-6 divisions in interaction with confluent hMSCs. Seeding ratio INA-6:MSC = 4:20. A, Three examples of dividing INA-6 cells generating either two MA, or one MA and one nMA dau…
View article: FIGURE 5 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 5 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Functional analysis of MSC-interacting subpopulations (A–C): Functional enrichment analysis of differentially expressed genes (from RNA-seq) using Metascape. A, Gene ontology (GO) cluster analysis of gene lists that are unique for MA (left…
View article: Supplementary Video 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Video 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Video 2
View article: Supplementary Table 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Table 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Table 3
View article: Supplementary Video 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Video 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Video 1
View article: FIGURE 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Time-lapse analysis of INA-6 detachment from INA-6 aggregates and hMSCs. A, Frequency of observed INA-6 aggregates that did or did not lose INA-6 cell(s). A total of 87 aggregates were evaluated per datapoint. B, Example of a “disseminatin…
View article: FIGURE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
INA-6 growth conformations and survival on hMSCs. A, Interaction of INA-6 (green) with hMSCs (black, negative staining) at different INA-6 densities (constant hMSC densities). Scale bar = 200 µm. B, Frequency of single hMSCs (same as B) th…
View article: Supplementary Video 4 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Video 4 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Video 4
View article: FIGURE 4 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 4 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Separation and gene expression of INA-6 subpopulations. A, Schematic of WPSC separating nMA-INA6 from MA-INA6. A coculture 96-well plate is turned upside down and attached on top of a “catching plate,” forming a “well-plate sandwich.” nMA-…
View article: Supplementary Video 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Video 3 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Video 3
View article: Supplementary Video 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Video 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Video 2
View article: Supplementary Table 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
Supplementary Table 1 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Supplementary Table 1
View article: FIGURE 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
FIGURE 2 from Modeling Myeloma Dissemination <i>In Vitro</i> with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics Open
Time-lapse analysis of INA-6 detachment from INA-6 aggregates and hMSCs. A, Frequency of observed INA-6 aggregates that did or did not lose INA-6 cell(s). A total of 87 aggregates were evaluated per datapoint. B, Example of a “disseminatin…