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View article: Phase I/II Study of Intratumoral Ad/Purine Nucleoside Phosphorylase (Gedeptin) With Fludarabine Phosphate in Patients With Recurrent Head and Neck Cancer
Phase I/II Study of Intratumoral Ad/Purine Nucleoside Phosphorylase (Gedeptin) With Fludarabine Phosphate in Patients With Recurrent Head and Neck Cancer Open
PURPOSE Ad/PNP (Gedeptin) is a nonreplicating adenoviral vector expressing E. coli purine nucleoside phosphorylase (PNP) for intratumoral injection (IT) followed by intravenous (IV) fludarabine. The resulting metabolite, fluoroadenine (F-A…
View article: Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses
Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses Open
Most cancer patients diagnosed with late-stage head and neck squamous cell carcinoma are treated with chemoradiotherapy, which can lead to toxicity. One potential alternative is tumor-limited conversion of a prodrug into its cytotoxic form…
View article: Evaluating antitumor activity of <scp><i>Escherichia coli</i></scp> purine nucleoside phosphorylase against head and neck patient‐derived xenografts
Evaluating antitumor activity of <span><i>Escherichia coli</i></span> purine nucleoside phosphorylase against head and neck patient‐derived xenografts Open
Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading‐edge patient‐der…