Reginald Tran
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View article: Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma
Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma Open
Multiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (B…
View article: Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma
Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma Open
Multiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (B…
View article: Redefining hyperviscosity in acute leukemia: Potential implications for red cell transfusions in the microvasculature
Redefining hyperviscosity in acute leukemia: Potential implications for red cell transfusions in the microvasculature Open
Hyperleukocytosis is an emergency of acute leukemia leading to blood hyperviscosity, potentially resulting in life‐threatening microvascular obstruction, or leukostasis. Due to the high number of red cells in the circulation, hematocrit/he…
View article: Factor XIII activity mediates red blood cell retention in venous thrombi
Factor XIII activity mediates red blood cell retention in venous thrombi Open
Venous thrombi, fibrin- and rbc-rich clots triggered by inflammation and blood stasis, underlie devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition, rbc are thought to become passively trapped in thro…
View article: Bio-inspired fluidic thermal angular accelerometer with inherent linear acceleration rejection
Bio-inspired fluidic thermal angular accelerometer with inherent linear acceleration rejection Open
This paper reports on the design, simulation, fabrication and characterization of a bio-inspired angular accelerometer. The sensor mimics the semicircular canals in mammalian vestibular systems. The device pairs a fluid-filled microtorus w…
View article: Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition
Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition Open
Key Points The geometric orientation of the underlying matrix regulates platelet α-granule secretion. On geometrically constrained matrices, platelets self-deposit additional matrix, providing more cell membrane to extend spreading.