Reham Abo Elwafa
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View article: Study of the Significance of Long Noncoding RNAs: Taurine-upregulated Gene-1, Urothelial Carcinoma-associated-1, Nuclear Paraspeckle Assembly Transcript-1, and Metastasis-associated Lung Adenocarcinoma Transcript-1 in Multiple Myeloma
Study of the Significance of Long Noncoding RNAs: Taurine-upregulated Gene-1, Urothelial Carcinoma-associated-1, Nuclear Paraspeckle Assembly Transcript-1, and Metastasis-associated Lung Adenocarcinoma Transcript-1 in Multiple Myeloma Open
BACKGROUND: Disease of multiple myeloma (MM) is a resistant blood cancer involving clonal plasma cells and marked by symptoms such as anemia, bone pain, and kidney failure. Long nonprotein-coding RNAs (lncRNAs), for instance, taurine-upreg…
View article: The Fusion Genes and Their Relation with Genetic Variants in Egyptian AML Patients
The Fusion Genes and Their Relation with Genetic Variants in Egyptian AML Patients Open
NGS has a major role in detection of genetic variants and fusions, which will have an impact on AML patient's prognosis.
View article: Clinical and laboratory characteristics of refractory microcytic hypochromic anemia pediatric patients
Clinical and laboratory characteristics of refractory microcytic hypochromic anemia pediatric patients Open
Introduction Iron deficiency anemia (IDA) is a common disease responsible for a wide range of disability and morbidity especially in young children, and it can cause irreversible neurocognitive problems in the early one thousand days of li…
View article: Identifying SARS-CoV-2 lineage and spike protein mutations: A single center cross-sectional study
Identifying SARS-CoV-2 lineage and spike protein mutations: A single center cross-sectional study Open
Background: Since the onset of SARS-CoV-2 pandemic, it has become a hot spot for research. Aim: This study aimed to detect variations in the spike protein of SARS-CoV-2 isolated from Egyptian patients and correlate them with laboratory dat…
View article: The relation of mTOR with diabetic complications and insulin resistance in patients with type 2 diabetes mellitus
The relation of mTOR with diabetic complications and insulin resistance in patients with type 2 diabetes mellitus Open
Background Dysregulation of the mechanistic target of rapamycin (mTOR) has been related to several metabolic conditions, notably obesity and type 2 diabetes (T2DM). This study aimed to evaluate the role of mTOR in patients with T2DM, and i…
View article: Molecular profiling of acute myeloid leukemia with Runx1-Runx1t1 fusion
Molecular profiling of acute myeloid leukemia with Runx1-Runx1t1 fusion Open
Introduction Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of immature myeloid cells. Among the genetic alterations in AML, the RUNX1- RUNX1T1 fusion, resulting from the t (8; …
View article: Molecular characteristics of NPM1 mutations in AML patients using targeted NGS
Molecular characteristics of NPM1 mutations in AML patients using targeted NGS Open
Background Acute myeloid leukemia (AML) is a clonal hematopoietic stem cell malignancy characterized by the accumulation of myeloid progenitor cells with arrested differentiation, leading to the suppression of normal hematopoiesis. The dis…
View article: KRAS mutations in patients with AML: clinical characteristics and not reported mutations using NGS
KRAS mutations in patients with AML: clinical characteristics and not reported mutations using NGS Open
Background AML is a complex and heterogeneous disease. The KRAS gene is one of the important genes in the pathogenesis of acute myeloid leukemia (AML). Mutant RAS can promote oncogenesis via different mechanisms including oncogenic transcr…
View article: Serum MFAP4 as a Non Invasive Diagnostic Marker of Oesophageal Varices in Cirrhotic Hepatitis C Virus Patients
Serum MFAP4 as a Non Invasive Diagnostic Marker of Oesophageal Varices in Cirrhotic Hepatitis C Virus Patients Open
Background and study aim: HCV induced liver cirrhosis is the primary cause of liver-related mortality, with liver disease ranking as the world's tenth greatest cause of death. The portal pressure remains below the threshold at which varice…
View article: Serum Lactadherin as a Diagnostic Biomarker in Hepatitis C Virus Cirrhotic Patients with and without Hepatocellular Carcinoma
Serum Lactadherin as a Diagnostic Biomarker in Hepatitis C Virus Cirrhotic Patients with and without Hepatocellular Carcinoma Open
Background and study aim: Hepatocellular carcinoma (HCC) is commonly occurs in association with cirrhosis which is the end stage of HCV infection. Although early HCC detection is important for a better prognosis, efficient biomarkers are s…
View article: Evaluation of the diagnostic performance of circulating microRNAs for the diagnosis of autism spectrum disorders
Evaluation of the diagnostic performance of circulating microRNAs for the diagnosis of autism spectrum disorders Open
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with genetic and environmental influences. Recently, microRNA (miRNA), has been identified as a potential contributor to the pathogenesis of several neurodevelopmen…
View article: Manual method versus flow cytometry for diagnosing spontaneous bacterial peritonitis
Manual method versus flow cytometry for diagnosing spontaneous bacterial peritonitis Open
Background Diagnosing spontaneous bacterial peritonitis (SBP) requires a high clinical index of suspicion because the clinical presentation varies widely. Early detection and treatment of SBP are crucial for improving survival rates. Ascit…
View article: MYOSTATIN AS A POTENTIAL DIAGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH SARCOPENIA
MYOSTATIN AS A POTENTIAL DIAGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH SARCOPENIA Open
Sarcopenia is a progressive loss of skeletal muscle mass and strength. Myostatin is a myokine, and a potent negative regulator of muscle growth. This study aimed to assess the accuracy of serum myostatin in prediction of Sarcopenia in elde…
View article: A case report of an Egyptian family with familial hypercholesterolemia and an exonic <scp>LINE</scp>‐1 insertion in <i>LDLR</i>
A case report of an Egyptian family with familial hypercholesterolemia and an exonic <span>LINE</span>‐1 insertion in <i>LDLR</i> Open
Background Familial hypercholesterolemia (MIM: PS143890) is a genetic disorder characterized by an increase in blood cholesterol. LDLR is one of the genes which their defect contributes to the disorder. Affected individuals may carry a het…
View article: DIAGNOSTIC AND PROGNOSTIC VALUE OF NOTCH-2 MUTATIONS IN DIFFUSE LARGE B CELL LYMPHOMA IN EGYPTIAN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 4
DIAGNOSTIC AND PROGNOSTIC VALUE OF NOTCH-2 MUTATIONS IN DIFFUSE LARGE B CELL LYMPHOMA IN EGYPTIAN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 4 Open
Notch has been reported to have both oncogenic and tumor suppressor roles, dependent on the cancer cell type.It is an evolutionally conserved signaling pathway, consisting a family of transmembrane receptors.These notch receptors will comm…
View article: Pituitary and growth disorders of pediatric survivors of head and neck tumors: a single center study
Pituitary and growth disorders of pediatric survivors of head and neck tumors: a single center study Open
Objective The aim was to explore the prevalence and risk factors for pituitary and growth disorders in pediatric brain and neck tumor survivors. Methods 203 children with brain or neck tumors that survived 2 years after tumors treatment we…
View article: DIAGNOSTIC AND PROGNOSTIC VALUE OF NOTCH-2 MUTATIONS IN DIFFUSE LARGE B-CELL LYMPHOMA IN EGYPTIAN PATIENTS.
DIAGNOSTIC AND PROGNOSTIC VALUE OF NOTCH-2 MUTATIONS IN DIFFUSE LARGE B-CELL LYMPHOMA IN EGYPTIAN PATIENTS. Open
In conclusion, Notch-2 was found to be mutated infrequently in DLBCL.It is associated with bad prognosis and usually occurs in ABC subtype.Besides this mutation occurred in about 5% of patients.In addition, in 45% of the patients they were…
View article: Genetic stratification reveals <i>COL4A</i> variants and spontaneous remission in Egyptian children with proteinuria in the first 2 years of life
Genetic stratification reveals <i>COL4A</i> variants and spontaneous remission in Egyptian children with proteinuria in the first 2 years of life Open
Aim The earlier the onset of proteinuria, the higher the incidence of genetic forms. Therefore, we aimed to analyse the spectrum of monogenic proteinuria in Egyptian children presenting at age <2 years. Methods The results of 27‐gene panel…
View article: Cervical Carcinoma in Shatby University Hospital and its Relation to Human Papilloma Virus
Cervical Carcinoma in Shatby University Hospital and its Relation to Human Papilloma Virus Open
Objective: To detect human papilloma virus infections and its different genotypes in cervical cancer cases in Shatby obstetrics and gynecology university hospital of Alexandria medical school.Patients and Methods: An observational analytic…
View article: Circulating MiRNA-373 as a Predictor of Response to Super-selective Transarterial Chemoembolization Bridging Therapy in Hepatocellular Carcinoma Patients Awaiting Liver Transplantation
Circulating MiRNA-373 as a Predictor of Response to Super-selective Transarterial Chemoembolization Bridging Therapy in Hepatocellular Carcinoma Patients Awaiting Liver Transplantation Open
Circulating pre-TACE MiR-373 could assist as a noninvasive predictor marker of response to TACE bridging therapy in early HCC patients awaiting liver transplantation.
View article: Expression of Enhancer of Zeste Homolog 2 (EZH2) Gene in Acute Myeloid Leukemia
Expression of Enhancer of Zeste Homolog 2 (EZH2) Gene in Acute Myeloid Leukemia Open
Low EZH2 expression is prevalent in Egyptian AML patients subsequently; it is suggested to function as tumor suppressor gene rather than an oncogene. Moreover, EZH2 downregulation is associated with resistance to chemotherapy and high mort…
View article: STUDY OF EZH2 GENE TYROSINE 641 MUTAION IN EGYPTIAN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA .
STUDY OF EZH2 GENE TYROSINE 641 MUTAION IN EGYPTIAN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA . Open
From this study we can conclude the following: 1. EZH2 in exon 16 is recurrently mutated in DLBCL.2. Multiple novel mutations have been detected in exon 16 including missense and non-coding mutations.3. EZH2 mutations seem to be a pathogen…
View article: Diagnostic validity of serum YKL-40 as a non-invasive diagnostic marker of oesophageal varices in cirrhotic hepatitis C virus patients
Diagnostic validity of serum YKL-40 as a non-invasive diagnostic marker of oesophageal varices in cirrhotic hepatitis C virus patients Open
Background Liver cirrhosis is the last phase of chronic hepatitis C virus infection. During the compensated phase, portal pressure is still below the point where varices start to form. On the contrary, decompensated individuals have clinic…
View article: Role of MicroRNA-326 and its Target Genes Bcl-xL and Bak as Potential Markers in Platelet Storage Lesion in Blood Banks
Role of MicroRNA-326 and its Target Genes Bcl-xL and Bak as Potential Markers in Platelet Storage Lesion in Blood Banks Open
Platelet transfusion is crucial in the management of various conditions such as quantitative and qualitative platelet disorders. A serious problem that impacts public health is the shortage of Platelet concentrates (PCs) that frequently af…
View article: MICRORNA 210 AND 34C-5P IN SEMINAL PLASMA IN PATIENTS WITH NON OBSTRUCTIVE AZOOSPERMIA
MICRORNA 210 AND 34C-5P IN SEMINAL PLASMA IN PATIENTS WITH NON OBSTRUCTIVE AZOOSPERMIA Open
miRNA 34c-5p and miRNA 210 expression levels are decreased in NOA than controls.• miRNA 34c-5p expression is lower than miRNA 210 expression in seminal plasma of NOA patients.• There is no significant association between seminal miRNA 34c-…
View article: Comparison of risk of malignancy indices in the preoperative evaluation of adnexal masses
Comparison of risk of malignancy indices in the preoperative evaluation of adnexal masses Open
Background: An adnexal mass patient is a common cause of hospital admission. The differentiation between malignant and benign cases is an important step in the management of such patients. The risk of malignancy index (RMI) is a simple sco…
View article: Expression of MicroRNA 181a and its Target Genes: BCL2 and NOVA1 in Plasma Cell Myeloma
Expression of MicroRNA 181a and its Target Genes: BCL2 and NOVA1 in Plasma Cell Myeloma Open
Background: Plasma cell myeloma (PCM) is one of the most common hematological malignancies. Despite advances in myeloma treatment, it remains an incurable disease. Studying the molecular bases of PCM has become essential to understand the …