Reiki Ogasawara
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View article: Event-free survival at 36 months is a suitable endpoint for diffuse large B-cell lymphoma patients treated with immunochemotherapy: real-world evidence from the North Japan Hematology Study Group
Event-free survival at 36 months is a suitable endpoint for diffuse large B-cell lymphoma patients treated with immunochemotherapy: real-world evidence from the North Japan Hematology Study Group Open
Information regarding follow-up duration after treatment for newly diagnosed diffuse large B-cell lymphoma (DLBCL) is important. However, a clear endpoint has yet to be established. We totally enrolled 2182 patients newly diagnosed with DL…
View article: Long-term follow-up of efficacy and safety in elderly patients with chronic myeloid leukemia treated with intermittent low dose dasatinib therapy
Long-term follow-up of efficacy and safety in elderly patients with chronic myeloid leukemia treated with intermittent low dose dasatinib therapy Open
Intermittent low dose dasatinib therapy brought about a beneficial effect in elderly patients with chronic-phase chronic myeloid leukemia (CML-CP) without inducing severe adverse events (AEs). An 85-year-old male patient, who received twic…
View article: R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation
R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation Open
Graft-versus-host disease (GVHD) is the major obstacle to performing allogeneic hematopoietic cell transplantation (allo-HCT). We and others have shown that intestinal stem cells are targeted in lower gastrointestinal GVHD. A leucine-rich …
View article: Donor Lymphocyte Infusion for Relapsed Acute Leukemia or Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation: A Single-Institute Retrospective Analysis
Donor Lymphocyte Infusion for Relapsed Acute Leukemia or Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation: A Single-Institute Retrospective Analysis Open
Objective The prognosis of the patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is poor, and therapeutic options are limited. In the present study, we investigated the efficacy and factors associat…
View article: Clinical utility of genomic profiling of <scp>AML</scp> using paraffin‐embedded bone marrow clots: <scp>HM‐SCREEN‐Japan</scp> 01
Clinical utility of genomic profiling of <span>AML</span> using paraffin‐embedded bone marrow clots: <span>HM‐SCREEN‐Japan</span> 01 Open
Next‐generation sequencing of AML has identified specific genetic mutations in AML patients. Hematologic Malignancies (HM)‐SCREEN‐Japan 01 is a multicenter study to detect actionable mutations using paraffin‐embedded bone marrow (BM) clot …
View article: Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas
Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas Open
Adult T-cell leukemia/lymphoma (ATLL) is one of the aggressive peripheral T-cell neoplasms with a poor prognosis. Accumulating evidence demonstrates that escape from adaptive immunity is a hallmark of ATLL pathogenesis. However, the mechan…
View article: New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination
New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination Open
View article: Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia: A case report
Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia: A case report Open
The histopathological finding of this gastric biopsy specimen should be called "neutropenic necrotizing gastritis".
View article: Myelomonocytic differentiation of leukemic blasts accompanied by differentiation syndrome in a case of <i>FLT3</i>-ITD-positive AML treated with gilteritinib
Myelomonocytic differentiation of leukemic blasts accompanied by differentiation syndrome in a case of <i>FLT3</i>-ITD-positive AML treated with gilteritinib Open
Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in acute myelogenous leukemia (AML) and the mutation is associated with poor prognosis of patients. Two distinct types of activating mutations have been i…
View article: Progression of Primary Gastric Diffuse Large B-Cell Lymphoma after <b><i>Helicobacter pylori</i></b> Eradication
Progression of Primary Gastric Diffuse Large B-Cell Lymphoma after <b><i>Helicobacter pylori</i></b> Eradication Open
In Helicobacter pylori-positive, localized primary gastric diffuse large B-cell lymphoma (DLBCL), an increasing number of reports have recently been published on the effectiveness of H. pylori eradication (HPE). However, HPE …
View article: <p>Disseminated Gonococcal Infection Associated with Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria: A Case Report and Literature Review</p>
Disseminated Gonococcal Infection Associated with Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria: A Case Report and Literature Review Open
Eculizumab has been developed as a breakthrough treatment for paroxysmal nocturnal hemoglobinuria (PNH). Not only for breakthroughs, eculizumab therapy is also known to increase the risk of invasive meningococcal infection. It has also bee…
View article: ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review
ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review Open
The macroscopic/endoscopic features of gastrointestinal ALK+ ALCL may be more similar to those of B-cell lymphomas rather than T-cell lymphomas.
View article: Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports
Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports Open
Gastrosplenic fistula (GSF) is a rare condition arising from gastric or splenic lymphomas. Surgical resection is the most common treatment, as described in previous reports. We report two cases of GSF in diffuse large B-cell lymphoma (DLBC…
View article: Acquired hemophilia A in solid cancer: Two case reports and review of the literature
Acquired hemophilia A in solid cancer: Two case reports and review of the literature Open
Acquired hemophilia A (AHA) is a rare, hemorrhagic autoimmune disease, whose pathogenesis involves reduced coagulation factor VIII (FVIII) activity related to the appearance of inhibitors against FVIII. Common etiological factors include a…
View article: Coexistence of primary colorectal follicular lymphoma and multiple myeloma: a case report
Coexistence of primary colorectal follicular lymphoma and multiple myeloma: a case report Open
Colorectal follicular lymphoma (FL) occurs less frequently than duodenal-type FL, which is an established entity, and primary multiple FL only involving the colon is rare. Furthermore, the coexistence of lymphoma and multiple myeloma (MM) …
View article: Intestinal Lymphatic Endothelial Cells Produce R-Spondin3
Intestinal Lymphatic Endothelial Cells Produce R-Spondin3 Open
View article: Graft-Versus-Host Disease Targets R-Spondin3-Producing Lymphatic Endothelial Cells in the Small Intestine
Graft-Versus-Host Disease Targets R-Spondin3-Producing Lymphatic Endothelial Cells in the Small Intestine Open
Background: R-Spondin (R-Spo) family is the ligand of LGR5 and consists of four proteins with a similar structure: R-Spo1-4. R-Spos strongly potentiate WNT/beta-catenin signaling and promote LGR5+ intestinal stem cells (ISCs) to self-renew…
View article: Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease
Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease Open
Key Points Skin GVHD targets Lgr5+ HFSCs in association with impaired hair regeneration and wound healing. Topical ruxolitinib, unlike corticosteroids, protects Lgr5+ skin stem cells and maintains skin homeostasis in skin GVHD.
View article: R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease
R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease Open
The intestinal microbial ecosystem is actively regulated by Paneth cell–derived antimicrobial peptides such as α-defensins. Various disorders, including graft-versus-host disease (GVHD), disrupt Paneth cell functions, resulting in unfavora…
View article: Graft-versus-host disease targets ovary and causes female infertility in mice
Graft-versus-host disease targets ovary and causes female infertility in mice Open
Key Points GVHD mediates donor T-cell infiltration and apoptosis of the ovarian follicle cells, leading to ovarian insufficiency and infertility. Ovarian insufficiency and infertility are independent of conditioning, and pharmacologic GVHD…
View article: A Case of Mature Natural Killer-Cell Neoplasm Manifesting Multiple Choroidal Lesions: Primary Intraocular Natural Killer-Cell Lymphoma
A Case of Mature Natural Killer-Cell Neoplasm Manifesting Multiple Choroidal Lesions: Primary Intraocular Natural Killer-Cell Lymphoma Open
Purpose: Natural killer (NK) cell neoplasm is a rare disease that follows an acute course and has a poor prognosis. It usually emerges from the nose and appears in the ocular tissue as a metastasis. Herein, we describe a case…
View article: α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice
α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice Open
Key Points Mn stimulates macrophages via Dectin-2 to induce donor Th17 differentiation after allogeneic bone marrow transplantation. Mn-induced Th17 cells accumulate in the lungs to cause pulmonary GVHD.